Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression

Molecular and Cellular Biology

Volumn 24, Issue 4, 2004, Pages 1453-1463

  Jenkins, Brendan J ^a,d   Grail, Dianne ^a   Inglese, Melissa ^a   Quilici, Cathy ^a   Bozinovski, Steven ^c   Wong, Peter ^b   Ernst, Matthias ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; DNA BINDING PROTEIN; GLYCOPROTEIN GP 130; IL 6 RECEPTOR SIGNAL TRANSDUCER GP130; IL-6 RECEPTOR SIGNAL TRANSDUCER GP130; INTERLEUKIN 6; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE PHOSPHATASE; SH PROTEIN TYROSINE PHOSPHATASE; SH PROTEIN-TYROSINE PHOSPHATASE; STAT1 PROTEIN; STAT3 PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; C FMS GENE; CELL DIVISION; CELL LINE; CELL MATURATION; COLONY FORMATION; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; MACROPHAGE; METABOLISM; MONOCYTE; MOUSE; MUTATION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; CELL DIVISION; CELL LINE; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, FMS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PROTEIN-TYROSINE-PHOSPHATASE; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0842282565     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.4.1453-1463.2004     Document Type: Article

References (41)

1. Bortner, D. M., M. Ulivi, M. F. Roussel, and M. C. Ostrowski. 1991. The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. Genes Dev. 5:1777-1785.
2. Buscher, D., R. A. Hipskind, S. Krautwald, T. Reimann, and M. Baccarini. 1995. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol. Cell. Biol. 15:466-475.
3. Chomarat, P., J. Banchereau, J. Davoust, and A. K. Palucka. 2000. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. 1:510-514.
4. Clutterbuck, R., R. Powles, J. Millar, and D. Catovsky. 2000. Interleukin-6 and other gp130-dependent cytokines selectively inhibit proliferation of macrophage-lineage hemopoietic progenitor cells. Exp. Hematol. 28:1120-1128.
5. Dai, X. M., G. R. Ryan, A. J. Hapel, M. G. Dominguez, R. G. Russell, S. Kapp, V. Sylvestre, and E. R. Stanley. 2002. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mommuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99:111-120.
6. Ernst, M., M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, J. K. Heath, and A. R. Dunn. 2001. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med. 194:189-203.
7. Ernst, M., U. Novak, S. E. Nicholson, J. E. Layton, and A. R. Dunn. 1999. The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation: involvement of STAT3. J. Biol. Chem. 274:9729-9737.
8. Fowles, L. F., M. L. Martin, L. Nelsen, K. J. Stacey, D. Redd, Y. M. Clark, Y. Nagamine, M. McMahon, D. A. Hume, and M. C. Ostrowski. 1998. Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling. Mol. Cell. Biol. 18:5148-5156.
9. Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. 1996. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5:449-460.
10. Gearing, D. P., C. J. Thut, T. VandeBos, S. D. Gimpel, P. B. Delaney, J. King, V. Price, D. Cosman, and M. P. Beckmann. 1991. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 10:2839-2848.
11. Gerhartz, C., B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. 1. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J. Biol. Chem. 271:12991-12998.
12. Guidez, F., A. C. Li, A. Horvai, J. S. Welch, and C. K. Glass. 1998. Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation. Mol. Cell. Biol. 18:3851-3861.
13. Hilton, D. J., A. A. Hilton, A. Raicevic, S. Rakar, M. Harrison-Smith, N. M. Gough, C. G. Begley, D. Metcalf, N. A. Nicola, and T. A. Willson. 1994. Cloning of a murine IL-11 receptor alpha-chain: requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13:4765-4775.
14. Himes, S. R., H. Tagoh, N. Goonetilleke, T. Sasmono, D. Oceandy, R. Clark, C. Bonifer, and D. A. Hume. 2001. A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J. Leukoc. Biol. 70:812-820.
15. Hume, D. A., X. Yue, I. L. Ross, P. Favot, A. Lichanska, and M. C. Ostrowski. 1997. Regulation of CSF-1 receptor expression. Mol. Reprod. Dev. 46:46-52.
16. Ikebuchi, K., G. G. Wong, S. C. Clark, J. N. Ihle, Y. Hirai, and M. Ogawa. 1987. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA 84:9035-9039.
17. Jansen, J. H., J. C. Kluin-Nelemans, J. Van Damme, G. J. Wientjens, R. Willemze, and W. E. Fibbe. 1992. Interleukin 6 is a permissive factor for monocytic colony formation by human hematopoietic progenitor cells. J. Exp. Med. 175:1151-1154.
18. Kim, H., T. S. Hawley, R. G. Hawley, and H. Baumann. 1998. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells. Mol. Cell. Biol. 18:1525-1533.
19. Kishimoto, T., S. Akira, M. Narazaki, and T. Taga. 1995. Interleukin-6 family of cytokines and gp130. Blood 86:1243-1254.
20. Klappacher, G. W., V. V. Lunyak, D. B. Sykes, D. Sawka-Verhelle, J. Sage, G. Brard, S. D. Ngo, D. Gangadharan, T. Jacks, M. P. Kamps, D. W. Rose, M. G. Rosenfeld, and C. K. Glass. 2002. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109:169-180.
21. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski. 1992. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol. Cell. Biol. 12:5355-5362.
22. Lawlor, K. E., I. K. Campbell, K. O'Donnell, L. Wu, and I. P. Wicks. 2001. Molecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritis. Arthritis Rheum. 44:442-450.
23. Lioubin, M. N., G. M. Myles, K. Carlberg, D. Bowtell, and L. R. Rohrschneider. 1994. Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Mol. Cell. Biol. 14:5682-5691.
24. Liu, H., H. Perlman, L. J. Pagliari, and R. M. Pope. 2001. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages: role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation. J. Exp. Med. 194:113-125.
25. Lord, K. A., A. Abdollahi, S. M. Thomas, M. DeMarco, J. S. Brugge, B. Hoffman-Liebermann, and D. A. Liebermann. 1991. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Mol. Cell. Biol. 11:4371-4379.
26. Metcalf, D. 1997. Murine hematopoietic stem cells committed to macrophage/dendritic cell formation: stimulation by Flk2-ligand with enhancement by regulators using the gp130 receptor chain. Proc. Natl. Acad. Sci. USA 94:11552-11556.
27. Mitani, H., N. Katayama, H. Araki, K. Ohishi, K. Kobayashi, H. Suzuki, K. Nishii, M. Masuya, K. Yasukawa, N. Minami, and H. Shiku. 2000. Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells. Br. J. Haematol. 109:288-295.
28. Mosley, B., C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman. 1996. Dual oncostatin M (OSM) receptors: cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271:32635-32643.
29. Murakami, M., M. Hibi, N. Nakagawa, T. Nakagawa, K. Yasukawa, K. Yamanishi, T. Taga, and T. Kishimoto. 1993. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260:1808-1810.
30. O'Farrell, A. M., Y. Liu, K. W. Moore, and A. L. Mui. 1998. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 17:1006-1018.
31. Ohtani, T., K. Ishihara, T. Atsumi, K. Nishida, Y. Kaneko, T. Miyata, S. Itoh, M. Narimatsu, H. Maeda, T. Fukada, M. Itoh, H. Okano, M. Hibi, and T. Hirano. 2000. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12:95-105.
32. Park, J. H., and L. Levitt. 1993. Overexpression of mitogen-activated protein kinase (ERK1) enhances T-cell cytokine gene expression: role of AP1, NF-AT, and NF-KB. Blood 82:2470-2477.
33. Reddy, M. A., B. S. Yang, X. Yue, C. J. Barnett, I. L. Ross, M. J. Sweet, D. A. Hume, and M. C. Ostrowski. 1994. Opposing actions of c-ets/PU. 1 and e-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. J. Exp. Med. 180:2309-2319.
34. Sasmono, R. T., D. Oceandy, J. W. Pollard, W. Tong, P. Pavli, B. J. Wainwright, M. C. Ostrowski, S. R. Himes, and D. A. Hume. 2003. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101:1155-1163.
35. Schmitz, J., M. Weissenbach, S. Haan, P. C. Heinrich, and F. Schaper. 2000. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275:12848-12856.
36. Stanley, E. R., K. L. Berg, D. B. Einstein, P. S. Lee, F. J. Pixley, Y. Wang, and Y. G. Yeung. 1997. Biology and action of colony-stimulating factor-1. Mol. Reprod. Dev. 46:4-10.
37. Takeda, K., B. E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 110:39-49.
38. Tebbutt, N. C., A. S. Giraud, M. Inglese, B. Jenkins, P. Waring, F. J. Clay, S. Malki, B. M. Alderman, D. Grail, F. Hollande, J. K. Heath, and M. Ernst. 2002. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8:1089-1097.
39. Tsuji, K., S. D. Lyman, T. Sudo, S. C. Clark, and M. Ogawa. 1992. Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 79:2855-2860.
40. Wiktor-Jedrzejczak, W., A. Bartocci, A. W. Ferrante, Jr., A. Ahmed-Ansari, K. W. Sell, J. W. Pollard, and E. R. Stanley. 1990. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc. Natl. Acad. Sci. USA 87:4828-4832.
41. Yang, B. S., C. A. Hauser, G. Henkel, M. S. Colman, C. Van Beveren, K. J. Stacey, D. A. Hume, R. A. Maki, and M. C. Ostrowski. 1996. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol. 16:538-547.