Calcineurin phosphatase activity: Activation by glucocorticoids and role of intracellular calcium

Transplantation

Volumn 77, Issue 2, 2004, Pages 259-267

  Tong, David C ^a   Buck, Sydney M ^a   Roberts, Brian R ^a   Klein, Janet D ^a   Tumlin, James A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; CALCINEURIN; CALCIUM; DACTINOMYCIN; DEXAMETHASONE; FURA 2; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INOSITOL TRISPHOSPHATE; LUCIFERASE; MIFEPRISTONE; PHOSPHATE; PHOSPHOLIPASE C; PROTEIN BAD;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DNA TRANSCRIPTION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RADIOIMMUNOASSAY;

ANNEXIN A5; CALCIUM; DACTINOMYCIN; DEXAMETHASONE; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRENES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; JURKAT CELLS; KINETICS; MIFEPRISTONE; PHOSPHOLIPASE C; PHOSPHORIC MONOESTER HYDROLASES; PYRROLIDINONES; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 0742287321     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000099267.05131.11     Document Type: Article

References (31)

1. McNally JG, Muller WG, Walker D, et al. The glucocorticoid receptor: Rapid exchange with regulatory sites in living cells. Science 1999; 287: 1262-1265.
2. Croxtall JD, Choudhury Q, Flower RJ. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 2000; 130: 289-298.
3. Watson CS, Gametchu B. Membrane-initiated steroid actions and the proteins that mediate them. Proc Soc Exp Biol Med 1999; 220: 9-19.
4. Cifone MG, Migliorati G, Parroni R, et al. Dexamethasone-induced thymocyte apoptosis: Apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase and caspases. Blood 1999; 93: 2282-2296.
5. Lou SJ, Chen YZ. The rapid inhibitory effect of glucocorticoid on cytosolic free Ca2+ increment induced by high extracellular K+ and its underlying mechanisms in PC12 cells. Biochem Biophys Res Commun 1998; 244: 403-407.
6. Mendoza C, Soler A, Tesarik J. Nongenomic steroid action: Independent targeting of a plasma membrane calcium channel and a tyrosine kinase. Biochem Biophys Res Commun 1995; 210: 518-523.
7. Sackey FNA, Watson CS, Gametchu B. Cell cycle regulation of a membrane glucocorticoid receptor in CCRF-CEM human ALL cells: Correlation to apoptosis. Am Physiol Soc 1997; 273: E571-E583.
8. Irvin BJ, Williams BL, Nilson AE, et al. Pleiotropic contributions of phospholipase C-gamma-1 to T cell antigen receptor-mediated signaling: Reconstitution studies of a PLC gamma-1 deficient Jurkat T cell line. Mol Cell Biol 2000; 20(4): 9149-9161.
9. Yablonski D, Kadlecek T, Weiss A. Identification of a phospholipase C gamma-1 SH3 domain-binding site in SLP-76 required for T cell receptor activation of PLC gamma-1 and NFAT. Mol Cell Biol 2001; 21(13): 4208-4218.
10. Baus E, Fabienne A, Dubois PM, et al. Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes. J Immunol 1995; 156: 4555-4561.
11. Nambiar MP, Enyedy EJ, Fisher CU, et al. Dexamethasone modulates TCR zeta chain expression and antigen receptor-mediated early signaling events in human T lymphocytes. Cell Immunol 2001; 208(1): 62-71.
12. Klee CB, Draetta GF, Hubbard MJ. Calcineurin. Adv Enzymol Relat Areas Mol Biol 1988; 61: 149-200.
13. Beals CR, Clipstone NA, Ho SN, et al. Nuclear localization of NF-ATc by a calcineurin-dependent cyclosporin-sensitive intramolecular interaction. Genes Dev 1997; 11: 824-834.
14. Clipstone NA, Crabtree GR. Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation. Nature 1992; 357: 695-697.
15. Shibasaki F, McKeon F. Calcineurin functions in Ca++-activated cell death in mammalian cells. J Cell Biol 1995; 131: 735-743.
16. Tumlin JA, Lea JP, Swanson CE, et al. Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins. J Clin Invest 1997; 99(6): 1217-1223.
17. Fruman DA, Klee CB, Bierer BE, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK-506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686-3690.
18. Bleasdale JE, Fisher SK. Use of U-73122 as an inhibitor of phospholipase C-dependent processes. Neuroprotocols 1993; 3: 125-133.
19. Wang HG, Pathan N, Ethell IM, et al. Ca++-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999; 284(5412): 339-343.
20. Someren JS, Faber LE, Klein JD, et al. Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms. Biochem Biophys Res Commun 1999; 260: 619-625.
21. Stemmer PM, Klee CB. Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B. Biochemistry 1994; 33: 6859-6866.
22. Smith RJ, Laurel SM, Justen JM, et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophiles: Effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther 1990; 253(2): 688-697.
23. Lam M, Dubyak G, Distlhorst CW. Effect of glucocorticoid treatment on intracellular calcium homeostasis in mouse lymphoma cells. Mol Endocrinol 1993; 7: 686-693.
24. Iseki R, Kudo Y, Iwata M. Early mobilization of Ca++ is not required for glucocorticoid-induced apoptosis in thymocytes. J Immunol 1993; 151(10): 5198-5207.
25. Bamberger CM, Else T, Bamberger AM, et al. Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes. J Clin Endocrinol Metab 1999; 84(11): 4055-4061.
26. Graber R, Losa GA. Changes in the activities of signal transduction and transport membrane enzymes in CEM lymphoblastoid cells by glucocorticoid-induced apoptosis. Anal Cell Pathol 1995; 8: 159-176.
27. Jayaraman T, Marks AR. Calcineurin is downstream of the inositol 1,4,5-triphosphate receptor in the apoptotic and cell growth pathways. J Biol Chem 2000; 275(9): 6417-6420.
28. Pazderka F, Batiuk TD, Halloran PF. The functional consequences of partial calcineurin inhibition in human peripheral blood mononuclear leucocytes. Transpl Immunol 1996; 4(1): 23-31.
29. Bunikowski R, Gerhold K, Brautigam M, et al. Effect of low-dose cyclosporin a microemulsion on disease severity, interleukin-6, interleukin-8 and tumor necrosis factor alpha production in severe pediatric atopic dermatitis. Int Arch Allergy Immunol 2001; 125(4): 344-348.
30. Jamieson CAM, Yamamoto KR. Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc Natl Acad Sci USA 2000; 97(13): 7319-7324.
31. Jayaraman T, Marks AR. Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways. J Biol Chem 2000; 275(9): 6417-6420.