메뉴 건너뛰기




Volumn 61, Issue 1, 2004, Pages 84-92

Current status of gene therapy for pancreatic cancer

Author keywords

And therapy; Gene; Oncology; Pancreas

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; BETA GLOBIN; CANCER VACCINE; CYTOSINE DEAMINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; GANCICLOVIR; GROWTH FACTOR; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LENTIVIRUS VECTOR; LIPOSOME; MONOCLONAL ANTIBODY; NAKED DNA; ONCOPROTEIN; ONYX 015; PARVOVIRUS VECTOR; PROTEIN P15; PROTEIN P16; PROTEIN P53; RECOMBINANT DNA; RETROVIRUS VECTOR; SMAD4 PROTEIN; THYMIDINE KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; UNINDEXED DRUG;

EID: 0742268064     PISSN: 01497944     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cursur.2003.07.023     Document Type: Article
Times cited : (11)

References (72)
  • 1
    • 0038444003 scopus 로고    scopus 로고
    • Adjuvant therapy in pancreatic cancer: Historical and current perspectives
    • Neoptolemos J.P. Cunningham D. Freiss H. et al. Adjuvant therapy in pancreatic cancer: historical and current perspectives Ann Oncol 14 2003 675-692
    • (2003) Ann. Oncol. , vol.14 , pp. 675-692
    • Neoptolemos, J.P.1    Cunningham, D.2    Freiss, H.3
  • 2
    • 0037214987 scopus 로고    scopus 로고
    • Developments in the systemic therapy of pancreatic cancer
    • el-Rayes B.F. Shileds A.F. Viatkevicius V. et al. Developments in the systemic therapy of pancreatic cancer Cancer Invest 21 2003 73-86
    • (2003) Cancer Invest. , vol.21 , pp. 73-86
    • el-Rayes, B.F.1    Shileds, A.F.2    Viatkevicius, V.3
  • 3
    • 0002269414 scopus 로고    scopus 로고
    • Epidemiology of pancreatic cancer
    • H. G. Berger, A. Warshaw, & D. L. Carr-Locke (Eds.), Boston, MA: Blackwell Scientific
    • Bramhall S. Dunn J. Neoptolemos J.P. Epidemiology of pancreatic cancer Berger H.G. Warshaw A. Carr-Locke D.L. et al. The Pancreas 1998 889-906 Blackwell ScientificBoston, MA
    • (1998) The Pancreas , pp. 889-906
    • Bramhall, S.1    Dunn, J.2    Neoptolemos, J.P.3
  • 4
    • 0028807727 scopus 로고
    • T lymphocyte directed gene therapy for ADA-SCID: Initial trial results after 4 years
    • Blaese R. Culver K. Miller A. et al. T lymphocyte directed gene therapy for ADA-SCID: initial trial results after 4 years Science 270 1995 475-480
    • (1995) Science , vol.270 , pp. 475-480
    • Blaese, R.1    Culver, K.2    Miller, A.3
  • 5
    • 0037314610 scopus 로고    scopus 로고
    • A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
    • Hecht J.R. Bedford R. Abbruzzese J.L. et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma Clin Cancer Res 9 2003 555-561
    • (2003) Clin. Cancer Res. , vol.9 , pp. 555-561
    • Hecht, J.R.1    Bedford, R.2    Abbruzzese, J.L.3
  • 6
    • 0035076823 scopus 로고    scopus 로고
    • Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
    • Mulvihill S. Warren R. Venook A. et al. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial Gene Ther 8 2001 308-315
    • (2001) Gene Ther. , vol.8 , pp. 308-315
    • Mulvihill, S.1    Warren, R.2    Venook, A.3
  • 7
    • 0002317434 scopus 로고    scopus 로고
    • R. Kuzrock, & M. Talpaz (Eds.) 2nd ed London: Martin Dunitz Ltd
    • Sakorafas G.H. Pancreatic cancer Kuzrock R. Talpaz M. Molecular biology in cancer medicine 2nd ed 1999 393-409 Martin Dunitz LtdLondon
    • (1999) Molecular Biology in Cancer Medicine , pp. 393-409
    • Sakorafas, G.H.1
  • 9
    • 0034434535 scopus 로고    scopus 로고
    • Gene therapy for pancreatic cancer-current and prospective strategies
    • Halloran C.M. Ghaneh P. Neoptolemos J.P. et al. Gene therapy for pancreatic cancer-current and prospective strategies Surg Oncol 9 2000 181-191
    • (2000) Surg. Oncol. , vol.9 , pp. 181-191
    • Halloran, C.M.1    Ghaneh, P.2    Neoptolemos, J.P.3
  • 10
    • 0030896871 scopus 로고    scopus 로고
    • Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers
    • Freiss H. Gaussmann M. Buchler M.W. Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers Int J Pancreatol 11 1997 43-52
    • (1997) Int. J. Pancreatol. , vol.11 , pp. 43-52
    • Freiss, H.1    Gaussmann, M.2    Buchler, M.W.3
  • 11
    • 0002311651 scopus 로고
    • Immunotherapy of pancreatic cancer with monoclonal antibody BW 494: Results from a multicentric phase I-II trials
    • H. G. Beger, M. Buehler, & G. Schulz (Eds.), Berlin: Springer
    • Buchler M. Kubel R. Klapdor R. et al. Immunotherapy of pancreatic cancer with monoclonal antibody BW 494: results from a multicentric phase I-II trials Beger H.G. Buehler M. Schulz G. et al. Cancer Therapy 3241 1989 SpringerBerlin
    • (1989) Cancer Therapy , pp. 3241
    • Buchler, M.1    Kubel, R.2    Klapdor, R.3
  • 12
    • 0034859416 scopus 로고    scopus 로고
    • Molecular biology of pancreatic cancer. Potential clinical implications
    • Sakorafas G.H. Tsiotos G. Molecular biology of pancreatic cancer. Potential clinical implications Biodrugs 15 2001 439-452
    • (2001) Biodrugs , vol.15 , pp. 439-452
    • Sakorafas, G.H.1    Tsiotos, G.2
  • 13
    • 0027109075 scopus 로고
    • p53 guardian of the genome
    • Lane D.P. p53 guardian of the genome Nature 358 1992 15-16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 14
    • 0026334753 scopus 로고
    • Abnormalities of p53 tumour suppressor gene in human pancreatic cancer
    • Barton C.M. Staddon S.L. Hughes C.M. et al. Abnormalities of p53 tumour suppressor gene in human pancreatic cancer Br J Cancer 64 1991 1076-1082
    • (1991) Br. J. Cancer , vol.64 , pp. 1076-1082
    • Barton, C.M.1    Staddon, S.L.2    Hughes, C.M.3
  • 15
    • 0025815451 scopus 로고
    • Identification of p53 as sequence-specific DNA-binding protein
    • Kern S.E. Kinzler K.W. Bruskin A. et al. Identification of p53 as sequence-specific DNA-binding protein Science 252 1991 1708-1711
    • (1991) Science , vol.252 , pp. 1708-1711
    • Kern, S.E.1    Kinzler, K.W.2    Bruskin, A.3
  • 16
    • 0027216028 scopus 로고
    • p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis
    • Casey G. Yamanaka Y. Freiss H. et al. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis Cancer Lett 69 1993 151-160
    • (1993) Cancer Lett. , vol.69 , pp. 151-160
    • Casey, G.1    Yamanaka, Y.2    Freiss, H.3
  • 17
    • 0028922149 scopus 로고
    • Association of p53 gene mutations with short survival in pancreatic adenocarcinoma
    • Nakamori S. Yashima K. Murakami Y. et al. Association of p53 gene mutations with short survival in pancreatic adenocarcinoma Jpn J Cancer Res 86 1995 174-181
    • (1995) Jpn. J. Cancer Res. , vol.86 , pp. 174-181
    • Nakamori, S.1    Yashima, K.2    Murakami, Y.3
  • 19
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas C. Hahn S.A. da Costa L.T. et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma Nat Genet 8 1994 27-32
    • (1994) Nat. Genet. , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    da Costa, L.T.3
  • 20
    • 0029880379 scopus 로고    scopus 로고
    • Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
    • Naumann M. Savitskaia N. Eilert C. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors Gastroenterology 110 1996 1215-1224
    • (1996) Gastroenterology , vol.110 , pp. 1215-1224
    • Naumann, M.1    Savitskaia, N.2    Eilert, C.3
  • 21
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor geneat 18q21.1
    • Hahn S.A. Schutte M. Hoque A.T.M.S. et al. DPC4, a candidate tumor suppressor geneat 18q21.1 Science 271 1996 350-353
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.M.S.3
  • 23
    • 14444284330 scopus 로고    scopus 로고
    • Tumor suppressive pathways in pancreatic cancer
    • Rozenblum E. Schutte M. Goggins M. et al. Tumor suppressive pathways in pancreatic cancer Cancer Res 57 1997 1731-1734
    • (1997) Cancer Res. , vol.57 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 24
    • 0036631849 scopus 로고    scopus 로고
    • Application of molecular biology studies to gene therapy treatment strategies
    • Gustin A. Pederson L. Miller R. Chan C. Vickers S.M. Application of molecular biology studies to gene therapy treatment strategies World J Surg 26 2002 854-860
    • (2002) World J. Surg. , vol.26 , pp. 854-860
    • Gustin, A.1    Pederson, L.2    Miller, R.3    Chan, C.4    Vickers, S.M.5
  • 25
    • 0027435936 scopus 로고
    • Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage
    • Yamanaka Y. Freiss H. Buchler M. et al. Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage Cancer Res 53 1993 5289-5296
    • (1993) Cancer Res. , vol.53 , pp. 5289-5296
    • Yamanaka, Y.1    Freiss, H.2    Buchler, M.3
  • 26
    • 0027365931 scopus 로고
    • Aberrant exprression of the type I fibroblast growth factor receptor in human pancreatic adenocarcinoma
    • Kobrin M.S. Yamanaka Y. Freiss H. et al. Aberrant exprression of the type I fibroblast growth factor receptor in human pancreatic adenocarcinoma Cancer Res 53 1993 4741-4744
    • (1993) Cancer Res. , vol.53 , pp. 4741-4744
    • Kobrin, M.S.1    Yamanaka, Y.2    Freiss, H.3
  • 27
    • 0027960891 scopus 로고
    • Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer
    • Leung H.Y. Gullick W.J. Lemoine N.R. Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer Int J Cancer 59 1994 667-675
    • (1994) Int. J. Cancer , vol.59 , pp. 667-675
    • Leung, H.Y.1    Gullick, W.J.2    Lemoine, N.R.3
  • 28
    • 0026595557 scopus 로고
    • The epidermal growth factor receptor in human pancreatic cancer
    • Lemoine N.R. Hughes C.M. Barton C.M. The epidermal growth factor receptor in human pancreatic cancer J Pathol 166 1992 7-12
    • (1992) J. Pathol. , vol.166 , pp. 7-12
    • Lemoine, N.R.1    Hughes, C.M.2    Barton, C.M.3
  • 29
    • 0027431337 scopus 로고
    • Overexpression of HER2/neu oncogene in human pancreatic carcinoma
    • Yamanaka Y. Freiss H. Kobrin M.S. et al. Overexpression of HER2/neu oncogene in human pancreatic carcinoma Hum Pathol 24 1993 1127-1134
    • (1993) Hum. Pathol. , vol.24 , pp. 1127-1134
    • Yamanaka, Y.1    Freiss, H.2    Kobrin, M.S.3
  • 30
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha
    • Kore M. Chandrasekar B. Yamanaka Y. et al. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha J Clin Ivest 90 1992 1352-1360
    • (1992) J. Clin. Ivest. , vol.90 , pp. 1352-1360
    • Kore, M.1    Chandrasekar, B.2    Yamanaka, Y.3
  • 31
    • 0028111134 scopus 로고
    • Induction and expression of heparin-binding FGF-like growth factor in human pancreatic cancer
    • Kobrin M.S. Funatomi H. Freiss H. et al. Induction and expression of heparin-binding FGF-like growth factor in human pancreatic cancer Biochem Biophys Res Commun 202 1994 1705-1709
    • (1994) Biochem. Biophys. Res. Commun. , vol.202 , pp. 1705-1709
    • Kobrin, M.S.1    Funatomi, H.2    Freiss, H.3
  • 32
    • 0031934765 scopus 로고    scopus 로고
    • Role of growth factors in pancreatic cancer
    • Kore M. Role of growth factors in pancreatic cancer Surg Oncol Clin N Am 7 1998 25-41
    • (1998) Surg. Oncol. Clin. N. Am. , vol.7 , pp. 25-41
    • Kore, M.1
  • 33
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
    • Friess H. Yamanaka Y. Büchler M. et al. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival Gastroenterology 105 1993 1846-1856
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.3
  • 34
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-beta responses
    • Derynek R. Zhang Y. Feng X.H. Smads: transcriptional activators of TGF-beta responses Cell 95 1998 737-740
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynek, R.1    Zhang, Y.2    Feng, X.H.3
  • 35
    • 0033573974 scopus 로고    scopus 로고
    • Smad 6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer
    • Kleeff J. Maruyama H. Freiss H. et al. Smad 6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer Biochem Biophys Res Commun 255 1999 268-273
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 268-273
    • Kleeff, J.1    Maruyama, H.2    Freiss, H.3
  • 36
    • 0033598408 scopus 로고    scopus 로고
    • The TGF-beta signalling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
    • Kleeff J. Ishiwata T. Maruyama H. et al. The TGF-beta signalling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer Oncogene 18 1999 5363-5372
    • (1999) Oncogene , vol.18 , pp. 5363-5372
    • Kleeff, J.1    Ishiwata, T.2    Maruyama, H.3
  • 37
    • 0344625381 scopus 로고    scopus 로고
    • TGF-beta signalling and cancer: Structural and functional consequences of mutations in Smads
    • Hata A. Shi Y. Massague J. TGF-beta signalling and cancer: structural and functional consequences of mutations in Smads Mol Med Today 4 1998 257-262
    • (1998) Mol. Med. Today , vol.4 , pp. 257-262
    • Hata, A.1    Shi, Y.2    Massague, J.3
  • 38
    • 0032767855 scopus 로고    scopus 로고
    • Molecular aspects of pancreatic cancer and future perspectives
    • Freiss H. Kleeff J. Korc M. et al. Molecular aspects of pancreatic cancer and future perspectives Dig Surg 16 1999 281-290
    • (1999) Dig. Surg. , vol.16 , pp. 281-290
    • Freiss, H.1    Kleeff, J.2    Korc, M.3
  • 39
    • 0033817601 scopus 로고    scopus 로고
    • The development of conditionally replicative adenoviruses for cancer therapy
    • Curiel D. The development of conditionally replicative adenoviruses for cancer therapy Clin Cancer Res 6 2000 3395-3399
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3395-3399
    • Curiel, D.1
  • 40
    • 0029794390 scopus 로고    scopus 로고
    • Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir
    • Yang L. Hwang R. Pandit L. et al. Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir Ann Surg 224 1996 405-414
    • (1996) Ann. Surg. , vol.224 , pp. 405-414
    • Yang, L.1    Hwang, R.2    Pandit, L.3
  • 41
    • 0023871422 scopus 로고
    • A safe packaging line for gene transfer: Separating viral genes on two different plasmids
    • Markowitz D. Goff S. Bank A. A safe packaging line for gene transfer: separating viral genes on two different plasmids J Virol 62 1988 1120-1124
    • (1988) J. Virol. , vol.62 , pp. 1120-1124
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 42
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titre and efficient gene transfer into mammalian and non-mammalian cells
    • Burns J.C. Friedman T. Driever W. et al. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titre and efficient gene transfer into mammalian and non-mammalian cells Proc Nat Acad Sci 90 1993 8033-8037
    • (1993) Proc. Nat. Acad. Sci. , vol.90 , pp. 8033-8037
    • Burns, J.C.1    Friedman, T.2    Driever, W.3
  • 43
    • 0035210823 scopus 로고    scopus 로고
    • Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma
    • Wesseling J.G. Yamamoto M. Adachi Y. et al. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma Cancer Gene Ther 8 2001 990-996
    • (2001) Cancer Gene Ther. , vol.8 , pp. 990-996
    • Wesseling, J.G.1    Yamamoto, M.2    Adachi, Y.3
  • 44
    • 0034608223 scopus 로고    scopus 로고
    • Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology
    • Mena I. Fischer J.R. Gebhard J. et al. Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology Virology 271 2000 276-288
    • (2000) Virology , vol.271 , pp. 276-288
    • Mena, I.1    Fischer, J.R.2    Gebhard, J.3
  • 45
    • 0031775399 scopus 로고    scopus 로고
    • An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
    • Dmitriev I. Krasnykh V. Miller C.R. et al. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism J Virol 72 1998 9706-9713
    • (1998) J. Virol. , vol.72 , pp. 9706-9713
    • Dmitriev, I.1    Krasnykh, V.2    Miller, C.R.3
  • 46
    • 0029793812 scopus 로고    scopus 로고
    • Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism
    • Krasnykh V. Mikheeva G.V. Douglas J.T. et al. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism J Virol 70 1996 6839-6846
    • (1996) J. Virol. , vol.70 , pp. 6839-6846
    • Krasnykh, V.1    Mikheeva, G.V.2    Douglas, J.T.3
  • 47
    • 0034219436 scopus 로고    scopus 로고
    • Adeno associated viral vectors as gene delivery vehicles
    • Carter P.J. Samulski R.J. Adeno associated viral vectors as gene delivery vehicles Int J Mol Med 6 2000 17-27
    • (2000) Int. J. Mol. Med. , vol.6 , pp. 17-27
    • Carter, P.J.1    Samulski, R.J.2
  • 48
    • 0033886486 scopus 로고    scopus 로고
    • Combined effects of adeno-associated virus vector and a herpes simplex virus mutant as neoplastic therapy
    • Kasuya H. Mizuno M. Yoshida J. et al. Combined effects of adeno-associated virus vector and a herpes simplex virus mutant as neoplastic therapy J Surg Oncol 74 2000 214-218
    • (2000) J. Surg. Oncol. , vol.74 , pp. 214-218
    • Kasuya, H.1    Mizuno, M.2    Yoshida, J.3
  • 49
    • 0031127930 scopus 로고    scopus 로고
    • Construction of recombinant adeno-associated virus vector containing the rat preproinsulin II gene
    • Peng L. Sidner R.A. Bochan M.R. et al. Construction of recombinant adeno-associated virus vector containing the rat preproinsulin II gene J Surg Res 69 1997 193-198
    • (1997) J. Surg. Res. , vol.69 , pp. 193-198
    • Peng, L.1    Sidner, R.A.2    Bochan, M.R.3
  • 50
    • 0031981317 scopus 로고    scopus 로고
    • Direct gene transfer into the rat pancreas using DNA-liposomes
    • Schmid R.M. Weidenbach H. Yamaguchi H. et al. Direct gene transfer into the rat pancreas using DNA-liposomes Eur J Clin Invest 28 1998 220-226
    • (1998) Eur. J. Clin. Invest. , vol.28 , pp. 220-226
    • Schmid, R.M.1    Weidenbach, H.2    Yamaguchi, H.3
  • 51
    • 0027155874 scopus 로고
    • In vivo promoter activity and transgene activity in mammalian tissues evaluated by tissue bombardment
    • Cheng L. Ziegelhoffer P.R. Yang N.S. In vivo promoter activity and transgene activity in mammalian tissues evaluated by tissue bombardment Proc Natl Acad Sci USA 90 1993 4455-4459
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4455-4459
    • Cheng, L.1    Ziegelhoffer, P.R.2    Yang, N.S.3
  • 53
    • 0030740155 scopus 로고    scopus 로고
    • Amphiregullin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targetted therapy
    • Funatomi H. Ikatura I. Pastan I. et al. Amphiregullin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targetted therapy Int J Cancer 72 1997 512-517
    • (1997) Int. J. Cancer , vol.72 , pp. 512-517
    • Funatomi, H.1    Ikatura, I.2    Pastan, I.3
  • 54
    • 0032445725 scopus 로고    scopus 로고
    • Antisense oligonucleotides to gastrin inhibits growth of human pancreatic cancer cells
    • Smith J.P. Verderame M.F. Zagon I.S. Antisense oligonucleotides to gastrin inhibits growth of human pancreatic cancer cells Cancer Lett 35 1999 107-112
    • (1999) Cancer Lett. , vol.35 , pp. 107-112
    • Smith, J.P.1    Verderame, M.F.2    Zagon, I.S.3
  • 55
    • 0025765770 scopus 로고
    • Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells
    • Sklar M. Thompson E. Welsh M. et al. Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells Mol Cell Biol 11 1991 3699-3710
    • (1991) Mol. Cell Biol. , vol.11 , pp. 3699-3710
    • Sklar, M.1    Thompson, E.2    Welsh, M.3
  • 56
    • 0032568329 scopus 로고    scopus 로고
    • Stable reintroduction of wild-type p53 (MTmp53ts) causes induction of apoptosis and neurocrine-like differentiation in human ductal pancreatic cancer cells
    • Lang D. Miknyoczki S.J. Huang L. et al. Stable reintroduction of wild-type p53 (MTmp53ts) causes induction of apoptosis and neurocrine-like differentiation in human ductal pancreatic cancer cells Oncogene 16 1998 1593-1602
    • (1998) Oncogene , vol.16 , pp. 1593-1602
    • Lang, D.1    Miknyoczki, S.J.2    Huang, L.3
  • 57
    • 0001011439 scopus 로고    scopus 로고
    • p53 and p16 gene therapy results in killing of pancreatic cells
    • Ghaneh P. Humphreys M. Greenhalf W. et al. p53 and p16 gene therapy results in killing of pancreatic cells Br J Surg 85 1998 1555
    • (1998) Br. J. Surg. , vol.85 , pp. 1555
    • Ghaneh, P.1    Humphreys, M.2    Greenhalf, W.3
  • 58
    • 0031648811 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 tumour suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer
    • Bouvet M. Bold R.J. Lee J. et al. Adenovirus-mediated wild-type p53 tumour suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer Ann Surg Oncol 5 1998 681-688
    • (1998) Ann. Surg. Oncol. , vol.5 , pp. 681-688
    • Bouvet, M.1    Bold, R.J.2    Lee, J.3
  • 59
    • 0031830091 scopus 로고    scopus 로고
    • Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene
    • Hwang R.F. Gordon E.M. Anderson W.F. et al. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene Surgery 124 1998 143-151
    • (1998) Surgery , vol.124 , pp. 143-151
    • Hwang, R.F.1    Gordon, E.M.2    Anderson, W.F.3
  • 60
    • 0001011439 scopus 로고    scopus 로고
    • p53 and p16 gene therapy results in killing of pancreatic cells
    • Ghaneh P. Humphreys M. Greenhalf W. et al. p53 and p16 gene therapy results in killing of pancreatic cells Br J Surg 85 1998 1555
    • (1998) Br. J. Surg. , vol.85 , pp. 1555
    • Ghaneh, P.1    Humphreys, M.2    Greenhalf, W.3
  • 61
    • 0033233277 scopus 로고    scopus 로고
    • p16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation
    • Kobayashi S. Shirasawa H. Sashiyama H. et al. p16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation Clin Cancer Res 5 1999 4182-4185
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4182-4185
    • Kobayashi, S.1    Shirasawa, H.2    Sashiyama, H.3
  • 62
    • 0009681406 scopus 로고    scopus 로고
    • Suppression of tumoric genicity in colorectal and pancreatic cancer cells by reconstitution of DPC4/SMAD4 is associated with expression changes of invasion, metastasis, and angiogenesis regulators
    • Schwartze-Waldhoff I. Klein S. Hintelmann A. et al. Suppression of tumoric genicity in colorectal and pancreatic cancer cells by reconstitution of DPC4/SMAD4 is associated with expression changes of invasion, metastasis, and angiogenesis regulators Gastroenterology 16 1999 pG2193
    • (1999) Gastroenterology , vol.16
    • Schwartze-Waldhoff, I.1    Klein, S.2    Hintelmann, A.3
  • 63
    • 0028148134 scopus 로고
    • Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo
    • DiMaio J. Clary B. Via D. et al. Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo Surgery 116 1994 205-213
    • (1994) Surgery , vol.116 , pp. 205-213
    • DiMaio, J.1    Clary, B.2    Via, D.3
  • 64
    • 0032549688 scopus 로고    scopus 로고
    • Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based therapy of human gastrointestinal tumor cells
    • Yang L. Chiang Y.W. Lenz H.J. et al. Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based therapy of human gastrointestinal tumor cells Hum Gene Ther 9 1998 719-728
    • (1998) Hum. Gene Ther. , vol.9 , pp. 719-728
    • Yang, L.1    Chiang, Y.W.2    Lenz, H.J.3
  • 65
    • 0032806082 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy for pancreatic cancer
    • Rigg A.S. Lemoine N.R. Genetic prodrug activation therapy for pancreatic cancer Ann N Y Acad Sci 880 1999 319-325
    • (1999) Ann. N. Y. Acad. Sci. , vol.880 , pp. 319-325
    • Rigg, A.S.1    Lemoine, N.R.2
  • 66
    • 0032486226 scopus 로고    scopus 로고
    • Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interlekin- or interleukin-4 in nude mice: A potentiality for cancer gene therapy
    • Kimura M. Tagawa M. Takenaga K. et al. Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interlekin- or interleukin-4 in nude mice: a potentiality for cancer gene therapy Cancer Lett 128 1998 47-53
    • (1998) Cancer Lett. , vol.128 , pp. 47-53
    • Kimura, M.1    Tagawa, M.2    Takenaga, K.3
  • 67
    • 0031087463 scopus 로고    scopus 로고
    • Inhibition of established pancreatic cancers following specific active immunotherapy with inteleukin-2 gene-transduced tumour cells
    • Clary B.M. Coveney E.C. Philip R. et al. Inhibition of established pancreatic cancers following specific active immunotherapy with inteleukin-2 gene-transduced tumour cells Cancer Gene Ther 4 1997 97-104
    • (1997) Cancer Gene Ther. , vol.4 , pp. 97-104
    • Clary, B.M.1    Coveney, E.C.2    Philip, R.3
  • 68
    • 0029825827 scopus 로고    scopus 로고
    • Characterization of immune responses in pancreatic carcinoma patients affect mutant p-21 ras peptide vaccination
    • Gjertsen M. Saeserdal I. Thorsby E. et al. Characterization of immune responses in pancreatic carcinoma patients affect mutant p-21 ras peptide vaccination Br J Cancer 74 1996 1829-1833
    • (1996) Br. J. Cancer , vol.74 , pp. 1829-1833
    • Gjertsen, M.1    Saeserdal, I.2    Thorsby, E.3
  • 70
    • 17344374264 scopus 로고    scopus 로고
    • A phase I clinical trial of lethally irradiated allogeneic pancreatic tumour cells transfected with GM-CSF gene for treatment of pancreatic adenocarcinoma
    • Jaffee E.M. Abrams R. Cameron J. et al. A phase I clinical trial of lethally irradiated allogeneic pancreatic tumour cells transfected with GM-CSF gene for treatment of pancreatic adenocarcinoma Hum Gene Ther 9 1998 1951-1971
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1951-1971
    • Jaffee, E.M.1    Abrams, R.2    Cameron, J.3
  • 71
    • 65749308863 scopus 로고    scopus 로고
    • The matrix metalloproteinases and their inhibitors in pancreatic cancer
    • Bramhall S.R. The matrix metalloproteinases and their inhibitors in pancreatic cancer Int J Pancreatol 21 1997 1-12
    • (1997) Int. J. Pancreatol. , vol.21 , pp. 1-12
    • Bramhall, S.R.1
  • 72
    • 0036350926 scopus 로고    scopus 로고
    • TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis
    • Bloomston M. Shaffi A. Zervos E.E. et al. TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis J Surg Res 102 2002 39-44
    • (2002) J. Surg. Res. , vol.102 , pp. 39-44
    • Bloomston, M.1    Shaffi, A.2    Zervos, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.