Raf and the road to cell survival: A tale of bad spells, ring bearers and detours

Biochemical Pharmacology

Volumn 66, Issue 8, 2003, Pages 1341-1345

  Troppmair, Jakob ^a   Rapp, Ulf R ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Apoptosis; Metabolism; Mitochondria; Raf; Survival

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN BCL 2; RAF PROTEIN;

APOPTOSIS; CELL DEATH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONFERENCE PAPER; ENERGY TRANSFER; GLYCOLYSIS; HUMAN; MEMBRANE PERMEABILITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; PHYSIOLOGY; REVIEW;

ANIMALS; APOPTOSIS; CELL SURVIVAL; HUMANS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION;

EID: 0642345208     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00483-0     Document Type: Conference Paper

References (43)

1. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell. 9(3):2002;459-470.
2. Adams J.M., Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26(1):2001;61-66.
3. Salvesen G.S., Duckett C.S. IAP proteins: blocking the road to death's door. Nat. Rev. Mol. Cell. Biol. 3(6):2002;401-410.
4. Le Mellay V., Troppmair J., Benz R., Rapp U.R. Negative regulation of mitochondrial VDAC channels by C-Raf kinase. BMC Cell. Biol. 3(1):2002;14.
5. Le Mellay V., Houben R., Troppmair J., Hagemann C., Mazurek S., Frey U., Beigel J., Weber C., Benz R., Eigenbrodt E., Rapp U.R. Regulation of glycolysis by Raf protein serine/threonine kinases. Adv. Enzyme Regul. 42:2002;317-332.
6. Dang C.V., Semenza G.L. Oncogenic alterations of metabolism. Trends Biochem. Sci. 24(2):1999;68-72.
7. Rapp UR, Troppmair J. Dominant oncogenes as cancer targets: role of raf kinases and myc, two master regulators of phenotypic and genotypic stability. In: Rosenthal R, Wahn U, Wolf H, editors. Einfluss von Genomprojekt und Pharmacogenetics auf die medizinische Entwicklung. Symposium der Novartis Stiftung. Stuttgart, New York: Schattauer Verlag; 2002. p. 25-42.
8. Cleveland J.L., Troppmair J., Packham G., Askew D.S., Lloyd P., Gonzalez-Garcia M., Nunez G., Ihle J.N., Rapp U.R. v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. Oncogene. 9(8):1994;2217-2226.
9. Jansen H.W., Lurz R., Bister K., Bonner T.I., Mark G.E., Rapp U.R. Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature. 307(5948):1984;281-284.
10. Cleveland J.L., Dean M., Wang J.Y., Hedge A.M., Ihle J.N., Rapp U.R. Abrogation of IL-3 dependence of myeloid FDC-P1 cells by tyrosine kinase oncogenes is associated with induction of c-myc. Curr. Top. Microbiol. Immunol. 141:1988;300-309.
11. Askew D.S., Ihle J.N., Cleveland J.L. Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin. Blood. 82(7):1993;2079-2087.
12. Zhong J., Troppmair J., Rapp U.R. Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria. Oncogene. 20(35):2001;4807-4816.
13. Wojnowski L., Stancato L.F., Zimmer A.M., Hahn H., Beck T.W., Larner A.C., Rapp U.R., Zimmer A. Craf-1 protein kinase is essential for mouse development. Mech. Dev. 76(1/2):1998;141-149.
14. Huser M., Luckett J., Chiloeches A., Mercer K., Iwobi M., Giblett S., Sun X.M., Brown J., Marais R., Pritchard C. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20(8):2001;1940-1951.
15. Mikula M., Schreiber M., Husak Z., Kucerova L., Ruth J., Wieser R., Zatloukal K., Beug H., Wagner E.F., Baccarini M. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 20(8):2001;1952-1962.
16. Gupta S. Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). Int. J. Oncol. 22(1):2003;15-20.
17. Wang H.G., Rapp U.R., Reed J.C. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell. 87(4):1996;629-638.
18. Wojnowski L., Zimmer A.M., Beck T.W., Hahn H., Bernal R., Rapp U.R., Zimmer A. Endothelial apoptosis in Braf-deficient mice. Nat. Genet. 16(3):1997;293-297.
19. Wiese S., Pei G., Karch C., Troppmair J., Holtmann B., Rapp U.R., Sendtner M. Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons. Nat. Neurosci. 4(2):2001;137-142.
20. Adrain C., Martin S.J. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem. Sci. 26(6):2001;390-397.
21. Cain K., Bratton S.B., Cohen G.M. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie. 84(2/3):2002;203-214.
22. Colombini M, Blachly-Dyson E, Forte M. VDAC, a channel in the outer mitochondrial membrane. In: Narahashi T, editor. Ion channels, vol. 4. New York, NY: Plenum Publishing Corp; 1996. p. 169-202.
23. Hagemann C, Mazurek S, Frey U, Beigel J, Weber C, Troppmair J, Eigenbrodt E, Rapp UR. A-Raf kinase and pyruvate kinase type M2 link mitogenic signaling with metabolism. Submitted for publication.
24. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., Reed J.C. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 80(2):1995;279-284.
25. Wang H.G., Takayama S., Rapp U.R., Reed J.C. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. U.S.A. 93(14):1996;7063-7068.
26. Götz R, Wiese S, Takayama S, Rossoll W, Schweizer U, Berzaghi M, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M. Essential role of Bag-1 in differentiation and survival of hematopoietic and neuronal cells. Submitted for publication.
27. Downward J., How B.A.D. Phosphorylation is good for survival. Nat. Cell. Biol. 1(2):1999;E33-E35.
28. Lizcano J.M., Morrice N., Cohen P. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 349(Pt 2):2000;547-557.
29. Donovan N., Becker E.B., Konishi Y., Bonni A. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J. Biol. Chem. 277(43):2002;40944-40949.
30. Konishi Y., Lehtinen M., Donovan N., Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol. Cell. 9(5):2002;1005-1016.
31. Schurmann A., Mooney A.F., Sanders L.C., Sells M.A., Wang H.G., Reed J.C., Bokoch G.M. p21-Activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol. Cell. Biol. 20(2):2000;453-461.
32. Wixler V., Smola U., Schuler M., Rapp U. Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cells. FEBS. Lett. 385(3):1996;131-137.
33. Daum G., Eisenmann-Tappe I., Fries H.W., Troppmair J., Rapp U.R. The ins and outs of Raf kinases. Trends Biochem. Sci. 19(11):1994;474-480.
34. Erhardt P., Schremser E.J., Cooper G.M. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19(8):1999;5308-5315.
35. Bergmann A., Agapite J., Steller H. Mechanisms and control of programmed cell death in invertebrates. Oncogene. 17(25):1998;3215-3223.
36. von Gise A., Lorenz P., Wellbrock C., Hemmings B., Berberich-Siebelt F., Rapp U.R., Troppmair J. Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals. Mol. Cell. Biol. 21(7):2001;2324-2336.
37. Digby MR, Rapp UR, Bowtell DDL, Lowenthal JW, Troppmair J, Sendtner M. Expression of the IAP homologue ITA suppresses TNFα induced apoptosis and NGF induced differentiation. Submitted for publication.
38. Jordan B.W., Dinev D., LeMellay V., Troppmair J., Gotz R., Wixler L., Sendtner M., Ludwig S., Rapp U.R. Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death. J. Biol. Chem. 276(43):2001;39985-39989.
39. Barker P.A., Salehi A. The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease. J. Neurosci. Res. 67(6):2002;705-712.
40. Harrington A.W., Kim J.Y., Yoon S.O. Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. J. Neurosci. 22(1):2002;156-166.
41. Mota M., Reeder M., Chernoff J., Bazenet C.E. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J. Neurosci. 21(14):2001;4949-4957.
42. Fedorov L.M., Tyrsin O.Y., Papadopoulos T., Camarero G., Gotz R., Rapp U.R. Bcl-2 determines susceptibility to induction of lung cancer by oncogenic C-Raf. Cancer Res. 62(21):2002;6297-6303.
43. Frade J.M. NRAGE and the cycling side of the neurotrophin receptor p75. Trends Neurosci. 23(12):2000;591-592.