Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults

American Journal of Clinical Nutrition

Volumn 78, Issue 5, 2003, Pages 985-992

  Upritchard, Jane E ^a   Schuurman, Caroelien R W C ^a   Wiersma, Anthony ^a   Tijburg, Lilian B M ^a   Coolen, Stefan A J ^a   Rijken, Philip J ^a   Wiseman, Sheila A ^a  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

Antioxidant capacity; Carotenoids; F2 isoprostanes; Malondialdehyde; Oxidation resistance; Oxidized LDL; Peroxidation; Spread; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; BIOLOGICAL MARKER; CAROTENOID; ISOPROSTANE; LOW DENSITY LIPOPROTEIN; XANTHOPHYLL; ALPHA CAROTENE; ALPHA-CAROTENE; ANTIOXIDANT; ISOPROSTANE DERIVATIVE; MARGARINE; PLACEBO;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; HUMAN; LIPID PEROXIDATION; NORMAL HUMAN; OXIDATION; OXIDATIVE STRESS; VITAMIN BLOOD LEVEL; AGED; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; HEALTH STATUS; MALE; MIDDLE AGED; NETHERLANDS; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL;

ILEX COOKII;

ADULT; AGED; ALPHA-TOCOPHEROL; ANTIOXIDANTS; BIOLOGICAL MARKERS; CAROTENOIDS; DOUBLE-BLIND METHOD; FEMALE; FOOD, FORTIFIED; HEALTH STATUS; HUMANS; ISOPROSTANES; LIPID PEROXIDATION; LUTEIN; MALE; MARGARINE; MIDDLE AGED; NETHERLANDS; OXIDATIVE STRESS; PATIENT COMPLIANCE; PLACEBOS; VITAMIN E;

EID: 0642310642     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/78.5.985     Document Type: Article

References (45)

1. Halliwell B, Gutteridge JM. Oxidative stress and disease. Free radicals in biology and medicine. Oxford, United Kingdom: Oxford University Press, 2000:617-783.
2. Jialal I, Fuller CJ, Huet BA. The effect of alpha-tocopherol supplementation on LDL oxidation. A dose-response study. Arterioscler Thromb Vasc Biol 1995;15:190-8.
3. Fuller CJ, Chandalia M, Garg A, Grundy SM, Jialal I. RRR-α- Tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus. Am J Clin Nutr 1996;63:753-9.
4. Reaven PD, Herold DA, Barnett J, Edelman S. Effects of vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM. Diabetes Care 1995;18:807-16.
5. Upritchard JE, Sutherland WH, Mann JI. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000;23:733-8.
6. Ciabattoni G, Davi G, Collura M, et al. In vivo lipid peroxidation and platelet activation in cystic fibrosis. Am J Respir Crit Care Med 2000;162:1195-201.
7. 2α and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999;99:224-9.
8. 2α is increased in hypercholesterolemia. Arterioscler Thromb Vasc Biol 1997;17:3230-5.
9. Pratico D, Ferro D, Iuliano L, et al. Ongoing prothrombotic state in patients with antiphospholipid antibodies: a role for increased lipid peroxidation. Blood 1999;93:3401-7.
10. Gey KF. Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer. Biofactors 1998;7:113-74.
11. Committee for Dietary Reference Intakes Vitamin E. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids. Washington, DC: National Academy Press, 2000:186-324.
12. McGavin JK, Mann JI, Skeaff CM, Chisholm A. Comparison of a vitamin E-rich diet and supplemental vitamin E on measures of vitamin E status and lipoprotein profile. Eur J Clin Nutr 2001;55:555-61.
13. Olmedilla B, Granado F, Southon S, et al. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. Br J Nutr 2001;85:227-38.
14. Vuilleumier JP, Keck EJ. Fluorimetric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. Micronutr Anal 1989;5:25-34.
15. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 1996;239:70-6.
16. Princen HM, van Duyvenvoorde W, Buytenhek R, et al. Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler Thromb Vasc Biol 1995;15:325-33.
17. Watson AD, Berliner JA, Hama SY, et al. Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest 1995;96:2882-91.
18. Coolen SAJ, van der Ham M, Wiseman SA, Verhagen H. Fast and sensitive determination of free and esterified 15-F2t-isoprostanes in plasma with high performance liquid chromatography tandem mass spectrometry. Free Radic Res 2002;36:120 (abstr).
19. Wong SH, Knight JA, Hopfer SM, Zaharia O, Leach CN Jr, Sunderman FW Jr. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 1987;33:214-20.
20. Lopes-Virella MF, Stone P, Ellis S, Colwell JA. Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem 1977;23:882-4.
21. Friedewald WT, Levy RI, Fredrickson DS. Estimation of low-density lipoprotein cholesterol in plasma, without the use of preparative ultrcentrifuge. Clin Chem 1972;18:499-502.
22. Castenmiller JJ, West CE, Linssen JP, het Hof KH, Voragen AG. The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans. J Nutr 1999;129.349-55.
23. Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc 1993;93:318-23.
24. Micozzi MS, Brown ED, Edwards BK, et al. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr 1992;55:1120-5.
25. van het Hof KH, Gartner C, Wiersma A, Tijburg LBM, Weststrate JA. Comparison of the bioavailability of natural palm oil carotenoids and synthetic beta-carotene in humans. J Argric Food Chem 1999;47: 1582-6.
26. Maskarinec G, Chan CL, Meng L, Franke AA, Cooney RV. Exploring the feasibility and effects of a high-fruit and -vegetable diet in healthy women. Cancer Epidemiol Biomarkers Prev 1999;8:919-24.
27. Zino S, Skeaff M, Williams S, Mann J. Randomized controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants. BMJ 1997;314:1787-91.
28. van het Hof KH, Tijburg LBM, de Boer HS, Wiseman SA, Weststrate JA. Antioxidant fortified spread increases the antioxidant status Eur J Clin Nutr 1998;52:292-9.
29. Durrington PN, Mackness B, Mackness MI. Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol 2001,21:473-80.
30. Sutherland WH, Walker RJ, de Jong SA, van Rij AM, Phillips V, Walker HL. Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat. Arterioscler Thromb Vasc Biol 1999; 19:1340-7.
31. Aviram M, Rosenblat M, Billecke S, et al. Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radic Biol Med 1999;26:892-904.
32. Holvoet P, Vanhaecke J, Janssens S, Van de WF, Collen D. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation 1998; 98:1487-94.
33. Holvoet P, Mertens A, Verhamme P, et al. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2001;21:844-8.
34. Holvoet P, Van Cleemput J, Collen D, Vanhaecke J. Oxidized low density lipoprotein is a prognostic marker of transplant-associated coronary artery disease. Arterioscler Thromb Vasc Biol 2000;20:698-702.
35. Moore K, Roberts LJ. Measurement of lipid peroxidation. Free Radic Res 1998;28:659-71.
36. Morrow JD. The isoprostanes: their quantification as an index of oxidant stress status in vivo. Drug Metab Rev 2000;32:377-85.
37. Griffiths HD, Møller L, Bartosz G, et al. Biomarkers. Mol Aspects Med 2002;23:101-208.
38. Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med 1999;27: 1114-21.
39. Dietrich M, Block G, Hudes M, et al. Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers. Cancer Epidemiol Biomarkers Prev 2002;11:7-13.
40. Meagher EA, Barry OP, Lawson JA, Rokach J, FitzGerald GA. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA 2001; 285:1178-82.
41. Patrignani P, Panara MR, Tacconelli S, et al. Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. Circulation 2000;102:539-45.
42. Reilly M, Delanty N, Lawson JA, FitzGerald GA Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 1996; 94:19-25.
43. Simons LA, von Konigsmark M, Simons J, Stocker R, Celermajer DS. Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults. Atherosclerosis 1999;143:193-9.
44. van den BR, van Vliet T, Broekmans WM, et al. A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers. J Nutr 2001;131:1714-22.
45. Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ. Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol 2001; 21:1029-33.