Ongoing prothrombotic state in patients with antiphospholipid antibodies: A role for increased lipid peroxidation

Blood

Volumn 93, Issue 10, 1999, Pages 3401-3407

  Praticò, Domenico ^b   Ferro, Domenico ^b   Iuliano, Luigi ^b   Rokach, Joshua ^b   Conti, Fabrizio ^b   Valesini, Guido ^b   FitzGerald, Garret A ^b   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONIC ACID; ASCORBIC ACID; ISOPROSTANE DERIVATIVE; PEPTIDE FRAGMENT; PHOSPHOLIPID ANTIBODY; PROTHROMBIN;

ADULT; ANTIOXIDANT ACTIVITY; ANTIPHOSPHOLIPID SYNDROME; ARACHIDONIC ACID METABOLISM; ARTICLE; CHEMICAL STRUCTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; LIPID PEROXIDATION; MALE; PRIORITY JOURNAL; THROMBOGENESIS; THROMBOSIS; TREATMENT OUTCOME; URINARY EXCRETION; VITAMIN SUPPLEMENTATION;

EID: 0033562602     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3401.410k36_3401_3407     Document Type: Article

References (32)

1. Hughes GRV: The antiphospholipid syndrome: Ten years on. Lancet 2:341, 1993
2. Hamsten A, Norberg R, Bjorkholm M, de Faire U, Holm G: Antibodies to cardiolipin in young survivors of myocardial infarction: An association with recurrent cardiovascular events. Lancet 1:113, 1986
3. Vaarala O, Manttari M, Manninen V, Tenkanen L, Puurunen M, Aho K, Palosuo T: Anticardiolipin antibodies and risk of myocardial infarction in a prospective cohort of middle-aged men. Circulation 91:23, 1995
4. Hasselaar P, Derksen RHWM, Blokzji L, De Groot PG: Cross-reactivity of antibodies directed against cardiolipin, DNA, endothelial cells and blood platelet. Thromb Haemost 63:169, 1990
5. Kornberg A, Blank M, Kaufman S, Shoenfeld Y: Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol 153:1328, 1994
6. Ferro D, Pittoni V, Quintarelli C, Basili S, Saliola M, Caroselli C, Valesini G, Violi F: Coexistence of antiphospholipid antibodies and endothelial perturbation in SLE patients with ongoing prothrombotic state. Circulation 95:1425, 1997
7. Olee T, Pierangeli SS, Handley HH, Le DT, Wei X, Lai CL, En J, Novotny W, Harris EN, Woods VL Jr, Chen PP: A monoclonal Ig G anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice. Proc Natl Acad Sci USA 93:8606, 1996
8. Ginsberg JS, Demers C, Brill-Edwards P, Johnston M, Bona R, Burrows RF, Weitzx J, Denburg JA: Increased thrombin generation and activity in patients with in systemic lupus erythematosus and anticardiolipin antibodies: Evidence for a prothrombotic state. Blood 81:2958, 1993
9. Ferro D, Quintarelli C, Valesini G, Violi F: Lupus anticoagulant and increased thrombin generation in patients with systemic lupus erythematosus. Blood 83:304, 1994
10. Horkko S, Miller E, Dudl E, Reaven P, Curtiss LK, Zvaifler NJ, Terkeltaub R, Pierangeli SS, Branch DW, Palinski W, Witztum JL: APL are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. J Clin Invest 98:815, 1996
11. Iuliano L, Praticò D, Ferro D, Pittoni V, Valesini G, Lawson J, FitzGerald GA, Violi F: Enhanced lipid peroxidation in patients positive for aPL. Blood 90:3931, 1997
12. Rokach J, Khanapure SP, Hwang SW, Adiyaman M, Lawson JA, FitzGerald GA: Nomenclature of isoprostanes: A proposal. Prostaglandins 54:853, 1997
13. Reilly M, Delanty N, Lawson JA, FitzGerald GA: Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 94:19, 1996
14. 2α, generation during coronary reperfusion: A potential quantitative marker of oxidative stress in vivo. Circulation 95:2492, 1997
15. 2α, by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2. J Biol Chem 271:8919, 1996
16. 2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest 3:998, 1994
17. 2α. J Biol Chem 270: 9800, 1995
18. 2α-I: An index of lipid peroxidation in humans. Proc Natl Acad Sci USA 95:3449, 1998
19. Harris EN: A reassessment of the antiphospholipid syndrome. J Rheumatol 17:733, 1990
20. Tan EM, Cohen AS, Fries JF, Massie AT, McShane DJ, Rothfield NF, Schaller JC, Talal N, Winchester RJ: The 1982 revised criteria for classification of systemic lupus erythematosus. Arthritis Rheum 25: 1271, 1982
21. Praticò D, Iuliano L, Basili S, Ferro D, Camastra C, Cordova C, FitzGerald GA, Violi F: Enhanced lipid peroxidation in hepatic cirrhosis. J Invest Med 46:51, 1998
22. Kutnink M, Hawkes WC, Schaus EE, Omaye ST: An internal standard method for unattended high performance chromatographic analysis of ascorbic acid in blood components. Anal Biochem 166:424, 1987
23. Ferro D, Saliola M, Quintarelli C, Valesini G, Basili S, Grandilli MA, Bonavita MS, Violi F: Methods for detecting lupus anticoagulant and their relation to thrombosis and miscarriage in patients with systemic lupus erythematosus. J Clin Pathol 45:332, 1992
24. Harris EN, Gharavi AE, Patel SP, Hughes GRV: Evaluation of the anticardiolipin antibody test: Report of an international workshop held 4 April 1986. Clin Exp Immunol 68:214, 1987
25. Armitage P, Berry G: Statistical Methods in Medical Research. Oxford, UK, Blackwell Scientific, 1990
26. Horkko S, Miller E, Branch DW, Palinski W, Witztum JL: The epitopes for some aPL are adducts of oxidized phospholipid and b2-glycoprotein 1 (and other proteins). Proc Natl Acad Sci USA 94:10356, 1997
27. Irani K, Xia Y, Zweier JL, Sollot SL, Der CJ, Fearon ER, Sundaresan M, Finkel T, Goldschmidt-Clermont PJ: Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 275:1649, 1997
28. Brisseau GF, Dackiw APB, Cheung PYC, Christie N, Rotstein OD: Postranscriptional regulation of macrophages tissue factor expression by antioxidants. Blood 85:1025, 1995
29. Oeth P, Mackman N: Salicylates inhibit lipopolysaccharyde-induced transcriptional activation of the tissue factor gene in human monocytic cells. Blood 86:4144, 1995
30. Nemerson Y: Tissue factor and hemostasis. Blood 71:1, 1988
31. Crutchley DJ, Que BJ: Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants. Circulation 92:238, 1995
32. Ceriello A, Bortolotti N, Pirisi M, Crescentini A, Tonutti L, Motz E, Russo A, Giacomello R, Stel G, Taboga C: Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM patients. Diabetes Care 20:1589, 1997