Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 2, 1996, Pages 117-128

  Lueßen, Henrik L ^a   De Leeuw, Bas J ^a   Pérard, David ^a   Lehr, Claus Michael ^b   De Boer, A G ^a   Verhoef, J Coos ^a   Junginger, Hans E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Carbomer; Carboxypeptidase A; Enzyme inhibition; Leucine aminopeptidase M; Mucoadhesives; Peroral peptide drug delivery; Poly(acrylates); Polycarbophil; Pyroglutamic acid aminopeptidase; Trypsin; Chymotrypsin

Indexed keywords

5 OXOPROLYL PEPTIDASE; AMINOPEPTIDASE; CALCIUM; CARBOMER; CARBOXYPEPTIDASE A; CHITOSAN DERIVATIVE; CHYMOTRYPSIN A; CYTOSOL AMINOPEPTIDASE; DIVALENT CATION; INTESTINE ENZYME; NOVEON; POLYACRYLIC ACID; POLYCARBOPHIL; POLYMER; PYROGLUTAMIC ACID; SEACURE; TRYPSIN; UNCLASSIFIED DRUG; ZINC;

ADHESION; ARTICLE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN DEGRADATION; VISCOSITY;

EID: 17344382638     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(95)00042-9     Document Type: Article

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