Time Window of Fibroblast Growth Factor-18-Mediated Neuroprotection after Occlusion of the Middle Cerebral Artery in Rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 1, 2004, Pages 114-123

  Ellsworth, Jeff L ^a   Garcia, Richard ^a   Yu, Jin ^b   Kindy, Mark S ^b,c,d  

^a ZYMOGENETICS INC   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d Molecular Therapeutics   (United States)

Author keywords

Cerebral blood flow; Neuroprotection; Stroke

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 18; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BLOOD PH; BRAIN BLOOD FLOW; BRAIN TEMPERATURE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; EXPLORATORY BEHAVIOR; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MEASUREMENT; MEMORY DISORDER; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; WORKING MEMORY;

EID: 0347994037     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000100063.36077.CD     Document Type: Article

References (46)

1. American Heart Association (2001) Heart and Stroke Statistical Update. Dallas. Texas: American Heart Association
2. Ay H, Ay I, Koroshetz WJ, Finklestein SP (1999) Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovasc Dis 9:131-135
3. Ay I, Sugimori H, Finklestein SP (2001) Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res 87:71-80
4. Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, Legos JJ, Erhardt JA, Ohlstein EH, Hunter AJ, Harrison DC, Philpott K, Smith BR, Adams JL, Parsons AA (2001) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Med Res Rev 21:129-145
5. Beaulieu C, de Crespigny A, Tong DC, Moseley ME, Albers GW, Marks MP (1999) Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann Neurol 46:568-578
6. Belayev L, Zhao W, Busto R, Ginsberg MD (1997) Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation. J Cereb Blood Flow Metab 17:1266-1280
7. Bogousslavsky J, Victor SJ, Salinas EO, Pallay A, Dorman GA, Fieschi C, Kaste M, Orgogozo JM, Chamorro A, Desmet A (2002) Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial. Cerebrovasc Dis 14:239-251
8. Cavallaro S, D'Agata V, Manickam P, Dufour F, Alkon DL (2002) Memory-specific temporal profiles of gene expression in the hippocampus. Proc Natl Acad Sci U S A 99:16279-16284
9. Colbourne F, Li H, Buchan AM, Clemens JA (1999) Continuing post-ischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. Stroke 30:662-668
10. Corbett D, Nurse S (1998) The problem of assessing effective neuroprotection in experimental cerebral ischemia. In: Progress in neurobiology), Great Britain: Elsevier Science. pp 531-548
11. Cuevas P, Carceller F, Ortega S, Zazo M, Nieto I, Gimenez-Gallego G (1991) Hypotensive activity of fibroblast growth factor. Science 254:1208-1210
12. Cuevas P, Carceller F, Reimers D, Saenz de Tejada I, Gimenez-Gallego G (1998) Acidic fibroblast growth factor rescues gerbil hippocampal neurons from ischemic apoptotic death. Neurol Res 20:271-274
13. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927
14. Dietrich WD, Busto R, Alonso O, Globus MY, Ginsberg MD (1993) Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 13:541-549
15. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischemic stroke: an integrated view. Trends Neurosci 22:391-397
16. Dono R (2003) Fibroblast growth factors as regulators of central nervous system development and function. Am J Physiol Regul Integr Comp Physiol 284: R867-881
17. Dose JM, Dhillon HS, Maki A, Kraemer PJ, Prasad RM (1997) Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat. J Neurotrauma 14:327-337
18. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:195-201
19. Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, Holdren MS, Lum KD, Moore EE, Raymond F, Ren H, Shea P, Sprecher C, Storey H, Thompson DL, Waggie K, Yao L, Fernandes RJ, Eyre DR, Hughes SD (2002) Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Osteoarthr Cartil 10:308-320
20. Ellsworth JL, Garcia R, Yu J, Kindy MS (2003) Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits following occlusion of the middle cerebral artery in rats. Stroke 34:1507-1512
21. Fisher M, Ratan R (2003) New perspectives on developing acute stroke therapy. Ann Neurol 53:10-20
22. Garcia JH (1992) The evolution of brain infarcts. A review. J Neuropathol Exp Neurol 51:387-393
23. Ginsberg MD, Belayer L, Zhao W, Huh PW, Busto R (1999) The acute ischemic penumbra: topography, life span, and therapeutic response. Acta Neurochir Suppl (Wien) 73:45-50
24. Gladstone DJ, Black SE (2001) Update on intravenous tissue plasminogen activator for acute stroke: from clinical trials to clinical practice. Cmaj 165:311-317
25. Gladstone DJ, Black SE, Hakim AM (2002) Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33:2123-2136
26. Hoshikawa M, Yonamine A, Konishi M, Itoh N (2002) FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development. Brain Res Mol Brain Res 105:60-66
27. Huang Z, Chen K, Huang PL, Finklestein SP, Moskowitz MA (1997) bFGF ameliorates focal ischemic injury by blood flow-independent mechanisms in eNOS mutant mice. Am J Physiol 272: H1401-1405
28. Iadecola C (1998) Cerebral Circulatory Dysregulation in Ischemia. In: Cerebrovascular disease: pathophysiology, diagnosis, and management (Ginsberg MD, Bogousslavsky J, eds), Malden, MA: Blackwell Science, pp 319-332
29. Kraemer PJ, Brown RW, Baldwin SA, Scheff SW (1996) Validation of a single-day Morris Water Maze procedure used to assess cognitive deficits associated with brain damage. Brain Res Bull 39:17-22
30. Lees KR (2001) Advances in neuroprotection trials. Eur Neurol 45:6-10
31. Li H, Colbourne F, Sun P, Zhao Z, Buchan AM, Iadecola C (2000) Caspase inhibitors reduce neuronal injury after local but not global cerebral ischemia in rats. Stroke 31:176-182
32. Li Y, Powers C, Jiang N, Chopp M (1998) Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat. J Neurol Sci 156:119-132
33. Liou AK, Clark RS, Henshall DC, Yin XM, Chen J (2003) To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 69:103-142
34. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
35. Maruoka Y, Ohbayashi N, Hoshikawa M, Itoh N, Hogan BM, Furuta Y (1998) Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech Dev 74:175-177
36. Matsui T, Mori T, Tateishi N, Kagamiishi Y, Satoh S, Katsube N, Morikawa E, Morimoto T, Ikuta F, Asano T (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part I: enhanced astrocytic synthesis of s-100beta in the periinfarct area precedes delayed infarct expansion. J Cereb Blood Flow Metab 22:711-722
37. Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (1998) Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol Chem 273:18161-18164
38. Read SJ (2000) Pharmacological therapy for acute stroke. Curr Opin Investig Drugs 1:329-339
39. Ringleb PA, Schellinger PD, Schranz C, Hacke W (2002) Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: useful or harmful? Stroke 33:1437-1441
40. Rosenblatt S, Irikura K, Caday CG, Finklestein SP, Moskowitz MA (1994) Basic fibroblast growth factor dilates rat pial arterioles. J Cereb Blood Flow Metab 14:70-74
41. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV (1999) Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol 19:2801-2806
42. Tretter YP, Hertel M, Munz B, ten Bruggencate G, Werner S, Alzheimer C (2000) Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nat Med 6:812-815
43. Whishaw IQ, Mittleman G, Bunch ST, Dunnett SB (1987) Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in rats. Behav Brain Res 24:125-138
44. Xu J, Liu Z, Ornitz DM (2000) Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 127:1833-1843
45. Yao DL, Masonic K, Petullo D, Li LY, Lincoln C, Wibberley L, Alderson RF, Antonaccio M (1999) Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. Brain Res 818:140-146
46. Zhang RL, Chopp M, Chen H, Garcia JH (1994) Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci 125:3-10