Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients

Clinical and Experimental Immunology

Volumn 118, Issue 3, 1999, Pages 412-416

  Roger, P M ^a   Breittmayer, J P ^a   Arlotto, C ^a   Pugliese, P ^a   Pradier, C ^a   Bernard Pomier, G ^a   Dellamonica, P ^a   Bernard, A ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Apoptosis; HAART; HIV infection; Protease inhibitors

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; LAMIVUDINE; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

ADULT; AGED; ANTIBIOTIC THERAPY; APOPTOSIS; ARTICLE; CELL COUNT; CYTOFLUOROMETRY; DISEASE COURSE; FEMALE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PATIENT CODING; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS PATHOGENESIS;

ADULT; AGED; ANTI-HIV AGENTS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIDANOSINE; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HUMANS; LAMIVUDINE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; STAVUDINE; VIRAL LOAD; ZALCITABINE; ZIDOVUDINE;

EID: 0032695189     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01076.x     Document Type: Article

References (26)

1. 1 Gulick RM, Mellors JW, Havlir D et al. Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Eng J Med 1997; 337:734-9.
2. 2 Roederer M. Getting to the HAART of T cell dynamics. Nat Med 1998; 4:145-6.
3. 3 Piketty C, Castiel P, Belec I et al. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS 1998; 12:745-50.
4. 4 Keita-Perse O, Roger PM, Pradier C, Pugliese P, Cottalorda J, Dellamonica P. Do viral load and CD8 cell count at initiation of tritherapy influence the increase of CD4 T-cell count? AIDS 1998; 12:F175-9.
5. 5 Fauci AS. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993; 262:1011-8.
6. 6 Angel JA, Kumar A, Parato K et al. Improvement of cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir. J Infect Dis 1998; 177:898-904.
7. 7 Tissot O, Viard JP, Rabian C, Ngo N, Burgard M, Rouzioux C, Penit C. No evidence for proliferation in the blood CD4+ T-cell pool during HTV-1 infection and triple combination therapy. AIDS 1998; 12:879-84.
8. 8 Gougeon ML, Lecoeur H, Dulioust A et al. Programmed cell death in peripheral lymphocytes from HTV-infected persons. J Immunol 1995; 156:3509-14.
9. 9 Katsitkis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA, Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995; 181:2029-36.
10. 10 Kobayashi N, Hamamoto Y, Yamamoto N, Tshi AI, Yonehara M, Yonchara S. Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. Proc Natl Acad Sci USA 1990; 87:9620-4.
11. 11 Banda NK, Bernier J, Kurahara DK et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992; 176:1099-106.
12. 12 Foster S, Beverley P, Aspinall R. gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor. Eur J Immunol 1995; 25:1778-82.
13. 13 Finkel TH, Tudor-Williams G, Banda NK et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nature Med 1995; 1:129-34.
14. 14 Adachi Y, Oyaizu N, Than S, McCloskey TW, Pahwa S. IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection. J Immunol 1996; 157:4184-93.
15. 15 Johnson N, Parkin JM. Antiretroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clin Exp Med 1998; 113:229-34.
16. 16 Bernard G, Breittmeyer JP, De Matteis M et al. E2/CD99 mediates programmed cell death of CD4+8+ human thymocytes with in intermediate CD3 density. J Immunol 1997; 158:2543-9.
17. 17 Roger PM, Bernard-Pomier G, Breittmayer JP et al. Apoptosis of peripheral T-lymphocytes triggered via E2/CD99 in human immunodeficiency virus infected-patients. [Abstract G74]. In: Programs and Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto. September 1997.
18. 18 Pradier C, Pugliese P, Caissotti C, Wehrlen-Martini S, Huynh-Van E, Pueyo B, Dellamonica P. Dossier médical informatisé pour les patients atteints d'infection par le VIH. l'expérience du service des Maladies Infectieuses du CHU de Nice. Méd Mal Infect 1998; 28: 291-5.
19. 19 Mellors JW, Munoz A, Giorgi JV et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Int Med 1997; 126:946-54.
20. 20 Sunila I, Vaccarezza M, Pantaleo G, Fauci AS, Orenstein JM. gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: an immunoelectron microscopic study. AIDS 1997; 11:27-32; 25:1778-82.
21. 20 Sunila I, Vaccarezza M, Pantaleo G, Fauci AS, Orenstein JM. gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: an immunoelectron microscopic study. AIDS 1997; 11:27-32; 25:1778-82.
22. 21 Cottrez F, Manca F, Dalgleish AG, Arenzana-Seisdedos, Capron A, Groux H. Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HTV-infected monocytes. J Clin Invest 1997; 99:257-66.
23. 22 Skowron G, Cole FB, Zheng D, Accetta G, Yen-Lieberman B. gp120-directed antibody-dependent cellular cytotoxicity as a major determinant of the rate of decline in CD4 percentage in HIV-1 disease. AIDS 1997; 11:1807-14.
24. 23 Karmochkine M, Parizot C, Calvez V, Coutellier A, Herson S, Debre P, Gorochov G. Susceptibility of peripheral blood mononuclear cells to apoptosis is correlated to plasma HTV load. AIDS Res Hum Retrovir 1998; 17:419-23.
25. 24 Estaquier J, Idziorek T, De Bels F et al. Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and non-pathogenic primate lentivirus infections. Proc Natl Acad Sci USA 1994; 91:9431-5.
26. 25 Kaufmann D, Pantaleo G, Sudre P et al. CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Lancet 1998; 351:723-4.