Lymphocyte-reactive autoantibodies in human immunodeficiency virus type 1-infected persons facilitate the deletion of cd8 t cells by macrophages

Journal of Infectious Diseases

Volumn 178, Issue 2, 1998, Pages 404-412

  Wang, Zhi Qin ^a   Horowitz, Harold W ^a   Orlikowsky, Thorsten ^a,b   Dudhane, Anita ^a   Weinstein, Arthur ^a,c   Hoffmann, Michael K ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD8 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE COUNT; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; TISSUE CULTURE;

EID: 0031824090     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515623     Document Type: Article

References (22)

1. Levy JA. HIV pathogenesis and long-term survival [editorial]. AIDS 1993;7:1401-10.
2. Robinson WE Jr, Motefiori DC, Mitchell WM. Will antibody-dependent enhancement of HIV-1 infection be a problem with AIDS vaccines? Lancet 1988;1:830-1.
3. Homsy J, Meyer M, Tateno M, Clarkson S, Levy JA. The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 1989;244:1357-60.
4. + individuals mediate antibody-dependent cellular cytotoxicity (ADCC). Clin Immunol Immunopathol 1990;54:192-9.
5. Dudhane A, Conti B, Orlikowsky T, et al. Monocytes in HIV-1 infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity. AIDS Res Hum Retroviruses 1996;12:885-92.
6. Dudhane A, Conti B, Orlikowsky T, et al. AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules. AIDS Res Hum Retroviruses 1996;12:893-9.
7. Wang ZQ, Orlikowsky T, Dudhane A, et al. Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120specific antibodies from AIDS patients. Eur J Immunol 1994;24:1553-7.
8. Riethmuller G, Rieber EP, Kiefersauer S, et al. From antilymphocyte serum to therapeutic monoclonal antibodies: first experiences with a chimeric CD4 antibody in the treatment of autoimmune disease. Immunol Rev 1992;129:81-104.
9. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992;175:331-40.
10. Meyaard L, Otto SA, Keet IP, Roos MT, Miedema F. Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease. J Clin Invest 1994;93:982-8.
11. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993;151:1224-34.
12. + T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation). Eur J Immunol 1994;24:859-66.
13. Orlikowsky T, Wang ZQ, Dudhane A, Horowitz H, Conti B, Hoffmann MK. Two distinct pathways of human macrophage differentiation are mediated by γ-interferon and interleukin 10. Immunology 1997;91:104-8.
14. Orlikowsky T, Wang ZQ, Dudhane A, Horowitz H, Conti B, Hoffmann MK. The cell surface marker phenotype of macrophages from HIV-1 infected subjects reflects an IL-10-enriched and IFN-γ-deprived donor environment. J Interferon Cytokine Res 1996;16:957-62.
15. Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996;14:207-32.
16. Koup RA, Safrit JT, Cao Y, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994;68:4650-5.
17. Zhu T, Mo H, Wang N, et al. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 1993;261:1179-81.
18. van't-Wout AB, Kootstra NA, Mulder-Kampinga GA, et al. Macrophagetropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission. J Clin Invest 1994;94:2060-7.
19. + lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986;234:1563-6.
20. + T cells. Science 1995;270:1811-5.
21. Baier M, Werner A, Bannen N, Metzner K, Kurth R. HIV suppression by interleukin-16 [letter]. Nature 1995;378:563.
22. + T cells. Immunol Today 1996;17:217-24.