Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes

Immunology

Volumn 92, Issue 3, 1997, Pages 317-320

  Aceituno, E ^a   Castanon S ^a   Jimenez C ^a   Subira D ^a   De Gorgolas M ^a   Fernandez Guerrero M ^a   Ortiz F ^a   Garcia R ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; PHYTOHEMAGGLUTININ;

ADULT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; COMPLEX FORMATION; DNA DEGRADATION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; NECROSIS; PRIORITY JOURNAL; SEROCONVERSION;

EID: 0030660471     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00361.x     Document Type: Article

References (21)

1. RAFF M.C. (1992) Social controls on cell survival and cell death. Nature 356, 397.
2. MEYAARD L., OTTO S.A., JONKER R.R., MIJNISTER M.J., KEET R.P. & MIEDMA F. (1992) Programmed death of T cells in HIV-1 infection. Science 257, 217.
3. AMEISEN J.C. (1992) Programmed cell death in AIDS: from hypotesis to experiments. Immunology Today 13, 288.
4. OYAIZU N. & PAWHA S. (1995) Role of apoptosis in HIV disease pathogenesis. J Clin Immunol 15, 217.
5. OYAIZU N., MCCLOSKEY T.W., CORONESI M., CHIRMULE M., KALYANARAMAN V.S. & PAHWA S. (1993) Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 crosslinked PBMCs from normal individuals. Blood 82, 3392.
6. BANDA N.K., BERNIER J., KURAHARA D.K. et al. (1992) Crosslinking CD4 by human immunodeficiency virus gp 120 primers T cells for activation inducing apoptosis. J Exp Med 176, 1099.
7. EULER H.H., KERN P., LOEFFLER H. & DIETRICH M. (1985) Precipitable immune-complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome. Clin Exp Immunol 59, 267.
8. + cell function down-regulation in AIDS patients. J Immunol 1992 148, 2709.
9. FEIJOÓ E., SUBIRÁ D., FDZ-GUERRERO M., GARCÍA R. & ORTÍZ F. (1995) Anti-CD4 activity in circulating inmmune complexes in HIV-infected patients. Im Arch Allergy Immunol 106, 366.
10. + patients contain infectious virus able to infect normal lymphocytes. J Allergy Clin Immunol 98, 827.
11. Centre for Disease Control (CDC) classification (1993) Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Marb Mortal Weekly Rep 41, 1.
12. NICOLETTI I., MIGLIORATI G., PAGLIACCI M.C., GRIGNANI F. & RICCARDI C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139, 271.
13. ORMEROD M.G., SUN X., BROWN D., SNOWDEN T.R. & COHEN G.M. (1993) Quantification of Apoptosis and necrosis by flow cytometry. Acta Oncologica 32, 417.
14. CARBONARI M., CIBATI M., CHERCHI M. et al. (1994) Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method. Blood 83, 1268.
15. SILICIANO R.F. (1996) The role of CD4 in HIV envelope-mediated pathogenesis. Curr Top Microbiol Immunol 205, 159.
16. KATSIKIS P.D., WUNDERLICK E.S. & HERZENBERG L.A. (1997) Fas antigen stimulation induces marked apoptosis of T lymphocytes in human inmunodeficiency virus-infected individuals. J Exp Med 18, 2029.
17. WANG Z, DUDHANE A., ORLIKOWSKY T. et al. (1994) CD4 engagement induces Fas antigen-dependent apoptosis in vivo. Eur J Immunol 24, 1553.
18. + cells from HIV-infected asymptomatic individuals. J Exp Med 175, 331.
19. SU L., KANESIMA H., BONYHADI M. et al. (1995) HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 2, 25.
20. FINKELL T.H., TUDOR-WILLIAMS G., BANDA N.K. et al. (1995) Apoptosis occurs predominantly in bystander cells and non in productive infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1, 129.
21. SEKIGAWA I., KOSHINO K., HISHIKAWA T. et al. (1995) Inhibitory effect of the immunosuppressant FK 506 on apoptotic cell death induced by HIV-1 gp120. Clin Immunol 15, 312.