Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus Type 1 (HIV-1)-infected children

Cell Death and Differentiation

Volumn 5, Issue 3, 1998, Pages 222-230

  Stricker, Kirstin ^a   Knipping, Eckart ^b   Böhler, Thomas ^a   Benner, Axel ^b   Krammer, Peter H ^b   Debatin, Klaus Michael ^a,c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Autoantibodies; CD4+ T cell depletion; CD95 (APO 1 Fas); Children; HIV; Soluble CD95

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; FAS LIGAND; RECEPTOR ANTIBODY;

AGE; APOPTOSIS; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; REGRESSION ANALYSIS; T LYMPHOCYTE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031874144     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400332     Document Type: Article

References (44)

1. Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F and Lynch DH (1995) Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181: 71-77
2. Banda NK, Bernier J, Kurahara DK, et al (1992) Cross-linking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp Med. 176: 1099-1106
3. Baumler C, Herr I, Bohler T, Benner A, Krammer PH and Debatin K-M (1996) Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1 infected children. Blood 88: 1741-1746
4. Blackburn R, Clenci M, Mann D, et al (1991) Common sequence in HIV 1 GP41 and HLA class II beta chains can generate crossreactive autoantibodies with immunosuppressive potential early in the course of HIV 1 infection. Adv. Exp. Med. Biol. 303 63-69
5. Böhler T, Nedel S, Debatin K-M (1997a) CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children with human immunodeficiency virus type 1. Pediatr. Res. 41:878-885
6. Böhler T, Baumler C, Herr I, Gross A, Kurz M and Debatin K-M (1997b) Activation of the CD95-system increases with disease progression in human immunodeficiency virus type-1-infected children and adolescents. Pediatr. Infect Dis J. 16: 754-759
7. Cheng J, Zhou T, Liu C, et al (1994) Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263: 1759-1762
8. Cleveland WS, Gross E (1991) Computational methods for local regression. Statistics and Computing 1: 47-62
9. Debatin K-M. Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A and Krammer PH (1994) High expression of APO-1 (CD95) on T lymphocytes from HIV-1 infected children. Blood 154: 3101-3103
10. Dhein J, Walczak H, Bäumler C, Debatin K-M and Krammer PH (1995) APO-1 mediated T cell receptor induced suicide. Nature 373: 438-441
11. 4+ T cells from human immunodeficiency virus-infected persons. J. Exp Med 182: 1759-1767
12. Fadeel B, Samuelsson A, HachiyaT, Broström C and Chiodi F (1997) Elevated serum levels of soluble Fas/APO-1 in human immunodeficiency virus-infected individuals. Blood 89: 4727-4730
13. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA and Herzenberg LA (1995) Fas antigen stimulation induces marked apoptosis of T lymphocytes in Human Immunodeficiency Virus infected individuals. J. Exp. Med. 181: 2029-2036
14. Fauci AS (1988) The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239: 617-622
15. Finkel TH and Banda NK (1994) Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? Curr. Opin Immunol. 6: 605-615
16. Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, Monks C, Baba TW, Ruprecht RM and Kupfer A (1995) Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1. 129-134
17. Golding H, Robey FA, Gates FT, et al (1988) Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp41-derived peptide and patients' sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immunedeficiertcy syndrome. J. Exp. Med 167: 914-923
18. Gougeon ML (1995) Does apoptosis contribute to CD4 T cell depletion in human immunodeficiency virus infection? Cell Death Differ. 2: 1-8
19. Gougeon ML, Lecoeur H, Duilioust A, Enouf M-G, Crouvoisier M, Goujard C, Debord T and Montagnier L (1996) Programmed cell death in peripheral lymphocytes from HIV-infected persons Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J. Immunol. 156: 3509-3520
20. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med 175 331-340
21. Itoh N, Yonehara S, Ishu A, et al (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis Cell 66: 233-243
22. Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M Sheer DH, Stanger BZ and Marshak-Rothstein A (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation Nature 373 444-448
23. Klas C, Debatin KM, Jonker RR and Krammer PH (1993) Activation interferes with the APO-1 pathway in mature human T cells. Int immunol. 5: 625-630
24. Knipping E, Debatin K-M, Stricker K. Heilig B, Eder A and Krammer PH (1995) Identification of soluble APO-1 in supernatants of human B and T cell lines and increased serum levels in 8 and T cell leukemias. Blood 85: 1562-1569
25. Krammer PH, Dhein J, Walczak H, et al (1994) The role of APO-1 mediated apoptosis in the immune system Immunol. Rev 142175-191
26. Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA and Fauci AS (1985) Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N. Engl J. Med. 313:79-84
27. Lehmann EL (1975) Nonparametrics: Statistical methods based on ranks. (San Francisco: Holden and Day)
28. Liang KY and Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73: 13-22
29. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RP and Miedema F (1992) Programmed death of T cells in HIV-1 infection. Science 257: 217-219
30. Miyawaki T, Uehara T, Nibu R, et al (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood J. Immunol 149. 3753-3758
31. Mouknm Z and Achour A (1995) Cytotoxic T lymphocytes specific for the synthetic veinctr peptide, a sequence found within the Fas molecule and anv gp120 in the blood of HIV-1 seropositive individuals. Cell Mol. Biol. 41 439-444
32. Muller S, Richalet P, Laurent Crawford A, et al (1992) Autoantibodies typical of nonorgan-specific autoimmune diseases in HIV-seropositive patients. AIDS 6: 933-942
33. Oehm A, Behrmann I, Falk W et al (1992) Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J. Biol. Chem. 267: 10709-10715
34. Oyaizu N and Pahwa S (1995) Role of apoptosis in HIV disease pathogenesis. J. Clin. Immunol. 15: 217-231
35. OyaizuN, McCloskeyTW, Coronesi M, Chirmule N, Kalyanaraman VS and Pahwa S (1993) Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 crosslinked PBMCs from normal individuals. Blood 82. 3392-3400
36. Oyaizu N, McCloskey TW, Than S, Hu R, Kalyanaraman VS and Pahwa S (1994) Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing Interferon-γ and Tumor Necrosis Factor-α secretion Blood 84. 2622-2631
37. Plaeger-Marshall S, Hultin P, Bertolli J, O'Rourke S, Kobayashi R, Kobayashi AL, Giorgi JV, Bryson Yand Stiehm ER (1993) Activationand differentiation antigens on T cells of healthy, at-risk, and HIV-infecied children J Acquir. Immune Defic. Syndr 6. 984-993
38. Silvestris F, Nagata S, Cafforio P, Silvestris N and Dammacco F (1996) Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients. J. Exp. Med. 184: 2287-2300
39. Szawlowski PW, Hanke Tand Randall RE (1993) Sequence homology between HIV-1 gp120 and the apoptosis mediating protein Fas. AIDS 7: 1018
40. Trauth BC, Klas C, Peters AM, et al (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245: 301-305
41. Via CS, Shearer GM (1989) Autoimmunity and the acquired immune deficiency syndrome. Curr Opin. Immunol. 1: 753-756
42. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM and Krammer PH (1995) The mechanism of HIV Tat and gp120-sensitized T cell apoptosis. Nature 375: 497-500
43. Yonehara S, Ishii A and Yonehara M (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor J. Exp. Med. 169: 1747-1756
44. Zagury JF, Bernard J, Achour A, et al (1993) Identification of CD4 and major histocompatibifity complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120. role in AIDS pathogenesis. Proc Natl. Acad Sci. USA 90:7573-7577