Inhibition of peripheral NF-κB activation by central action of α- melanocyte-stimulating hormone

Journal of Neuroimmunology

Volumn 99, Issue 2, 1999, Pages 211-217

  Ichiyama, Takashi ^a,b   Sakai, Tetsuhiro ^c   Catania, Anna ^d   Barsh, Gregory S ^e   Furukawa, Susumu ^b   Lipton, James M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Melanocyte stimulating hormone; 2 Adrenoreceptor; Inflammation; Melanocortin receptor; NF B; Spinal cord transection

Indexed keywords

ALPHA INTERMEDIN; ATENOLOL; ATROPINE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BUTOXAMINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELANOCORTIN RECEPTOR; PHENTOLAMINE; PROPRANOLOL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; INFLAMMATION; MALE; MOUSE; NEUROIMMUNOLOGY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD TRANSSECTION;

ACUTE DISEASE; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ALPHA-MSH; ANIMALS; ATENOLOL; ATROPINE; BLOTTING, WESTERN; BRAIN CHEMISTRY; BUTOXAMINE; DNA-BINDING PROTEINS; ENCEPHALITIS; I-KAPPA B PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCARINIC ANTAGONISTS; NEURAL PATHWAYS; NF-KAPPA B; PHENTOLAMINE; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032724994     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00122-8     Document Type: Article

References (46)

1. Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:1994;141-179.
2. Baldwin A.S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
3. Barnett C.C. Jr., Moore E.E., Partrick D.A., Silliman C.C. β-Adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release. J. Surg. Res. 70:1997;166-170.
4. Barrett P., MacDonald A., Helliwell R., Davidson G., Morgan P. Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family. J. Mol. Endocrinol. 12:1994;203-213.
5. Brown K., Gerstberger S., Carlson L., Franzoso G., Siebenlist U. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science. 267:1995;1485-1488.
6. Catania A., Lipton J.M. α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr. Rev. 14:1993;564-576.
7. Catania A., Rajora N., Capsoni F., Minonzio F., Star R.A., Lipton J.M. The neuropeptide α-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides. 17:1996;675-679.
8. Ceriani G., Macaluso A., Catania A., Lipton J.M. Central neurogenic antiinflammatory action of α-MSH: modulation of peripheral inflammation induced by cytokines and other mediators of inflammation. Neuroendocrinology. 59:1994;138-143.
9. Chhajlani V., Wikberg J.E. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309:1992;417-420.
10. Collart M.A., Baeuerle P., Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1990;1498-1506.
11. Deryckere F., Gannon F. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques. 16:1994;405.
12. Gantz I., Konda Y., Tashiro T., Shimoto Y., Miwa H., Munzert G., Watson S.J., DelValle J., Yamada T. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268:1993;8246-8250.
13. Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Watson S.J., DelValle J., Yamada T. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268:1993;15174-15179.
14. Green K.L. The anti-inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse. Br. J. Pharmacol. 45:1972;322-332.
15. Grimm S., Baeuerle P.A. The inducible transcription factor NF-κB: structure-function relationship of its protein subunits. Biochem. J. 290:1993;297-308.
16. 2-adrenoreceptor activation. Am. J. Physiol. 273:1997;E1203-E1208.
17. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12:1957;12-15.
18. Henkel T., Machleidt T., Alkalay I., Krönke M., Ben-Neriah Y., Baeuerle P.A. Rapid proteolysis of IκB-α is necessary for activation of transcriptional factor NF-κB. Nature. 365:1993;182-185.
19. Hiscott J., Marois J., Garoufalis J., D'Addario M., Roulston A., Kwan I., Pepin N., Lacoste J., Nguyen H., Bensi G., Fenton M. Characterization of a functional NF-κB site in the human interleukin 1β promotor: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13:1993;6231-6240.
20. Huang Q.H., Entwistle M.L., Alvaro J.D., Duman R.S., Hruby V.J., Tatro J.B. Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever. J. Neurosci. 17:1997;3343-3351.
21. Huang Q.H., Hruby V.J., Tatro J.B. Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release. Am. J. Physiol. 275:1998;R524-R530.
22. Inagaki N., Miura T., Daikoku M., Nagai H., Koda A. Inhibitory effects of β-adrenergic stimulants on increased vascular permeability caused by passive cutaneous anaphylaxis, allergic mediators, and mediator releasers in rats. Pharmacology. 39:1989;19-27.
23. Kumar A., Haque J., Lacoste J., Hiscott J., Williams B.R.G. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. U. S. A. 91:1994;6288-6292.
24. Kunsch C., Lang R.K., Rosen C.A., Shannon M.F. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6. J. Immunol. 153:1994;153-164.
25. Lentsch A.B., Shanley T.P., Sarma V., Ward P.A. In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13. J. Clin. Invest. 100:1997;2443-2448.
26. Libermann T.A., Baltimore D. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10:1990;2327-2334.
27. Lipton J.M., Catania A. Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol. Today. 18:1997;140-145.
28. Lipton J.M., Catania A. Mechanisms of antiinflammatory action of the neuroimmunomodulatory peptide α-MSH. Ann. N. Y. Acad. Sci. 840:1998;373-380.
29. Lipton J.M., Macaluso A., Hiltz M.E., Catania A. Central administration of the peptide α-MSH inhibits inflammation in the skin. Peptides. 12:1991;795-798.
30. Macaluso A., McCoy D., Ceriani G., Watanabe T., Biltz J., Catania A., Lipton J.M. Antiinflammatory influences of α-MSH molecules: central neurogenic and peripheral actions. J. Neurosci. 14:1994;2377-2382.
31. Maling H.M., Webster M.E., Williams M.A., Saul W., Anderson W. Jr. Inflammation induced by histamine, serotonin, bradykinin and compound 48/80 in the rat: antagonists and mechanisms of action. J. Pharmacol. Exp. Ther. 191:1974;300-310.
32. Manna S.K., Aggarwal B.B. α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents. J. Immunol. 161:1998;2873-2880.
33. Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T., Akira S. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10193-10197.
34. Mountjoy K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science. 257:1992;1248-1251.
35. 2-adrenoceptor in the rat astrocytes. J. Neuroimmunol. 88:1998;144-153.
36. Ollivier V., Parry G.C.N., Cobb R.R., de Prost D., Mackman N. Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J. Biol. Chem. 271:1996;20828-20835.
37. Rajora N., Ceriani G., Catania A., Star R.A., Murphy M.T., Lipton J.M. α-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line. J. Leukocyte Biol. 59:1996;248-253.
38. Rajora N., Boccoli G., Burns D., Sharma S., Catania A.P., Lipton J.M. α-MSH modulates local and circulating tumor necrosis factor-α in experimental brain inflammation. J. Neurosci. 17:1997;2181-2186.
39. Robbins L.S., Nadeau J.H., Johnson K.R., Kelly M.A., Roselli-Rehfuss L., Baack E., Mountjoy K.G., Cone R.D. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 72:1993;827-834.
40. 3-adrenoceptors. Eur. J. Pharmacol. 348:1998;53-60.
41. Roulston A., Lin R., Beauparlant P., Wainberg M.A., Hiscott J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-κB/Rel transcription factors. Microbiol. Rev. 59:1995;481-505.
42. Star R.A., Rajora N., Huang J., Stock R.C., Catania A., Lipton J.M. Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. U. S. A. 92:1995;8016-8020.
43. 2-adrenoreceptor stimulant, terbutaline. Acta Physiol. Scand. 101:1977;504-506.
44. Weidenfeld J., Crumeyrolle-Arias M., Haour F. Effect of bacterial endotoxin and interleukin-1 on prostaglandin biosynthesis by the hippocampus of mouse brain: role of interleukin-1 receptors and glucocorticoids. Neuroendocrinology. 62:1995;39-46.
45. Weiss J.M., Sundar S.K., Cierpial M.A., Ritchie J.C. Effects of interleukin-1 infused into brain are antagonized by α-MSH in a dose-dependent manner. Eur. J. Pharmacol. 192:1991;177-179.
46. Wong K.Y., Rajora N., Boccoli G., Catania A., Lipton J.M. A potential mechanism of local anti-inflammatory action of alpha-melanocyte-stimulating hormone within the brain: modulation of tumor necrosis factor-alpha production by human astrocytic cells. Neuroimmunomodulation. 4:1997;37-41.