Contribution of single-channel properties to the time course and amplitude variance of quantal glycine currents recorded in rat motoneurons

Journal of Neurophysiology

Volumn 81, Issue 4, 1999, Pages 1608-1616

  Singer, Joshua H ^a,b   Berger, Albert J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; GLYCINE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FACILITATION; HYPOGLOSSAL NERVE; INHIBITORY POSTSYNAPTIC POTENTIAL; MOTONEURON; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION;

EID: 0033055127     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.81.4.1608     Document Type: Article

References (57)

1. AGOPYAN, N., TOKUTOMI, N., AND AKAIKE, N. Protein kinase-A mediated phosphorylation reduces only the fast desensitizing glycine current in acutely dissociated ventromedial hypothalamic neurons. Neuroscience 56: 605-615, 1993.
2. AKAGI, H. AND MILEDI, R. Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science 242: 270-273, 1988.
3. ALVAREZ, F. J., DEWEY, D. E., HARRINGTON, D. A., AND FYFFE, R.E.W. Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord. J. Comp. Neurol. 379: 150-170, 1997.
4. BECHADE, C., COLIN, I., KIRSCH, J., BETZ, H., AND TRILLER, A. Expression of glycine receptor α subunits and gephyrin in cultured spinal neurons. Eur. J. Neurosci. 8: 429-435, 1996.
5. BEKKERS, J. M., RICHERSON, G. B., AND STEVENS, C. F. Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices. Proc. Natl. Acad. Sci. USA 87: 5359-5362, 1990.
6. BENNETT, M. R. The origin of gaussian distributions of synaptic potentials. Proc. Neurobiol. 46: 331-350, 1995.
7. BERGER, A. J., BAYLISS, D. A., AND VIANA, F. Development of hypoglossal motoneurons. J. Appl. Physiol. 81: 1039-1048, 1996.
8. BERGER, A. J., SINGER, J. H., AND ISAACSON, J. S. Biophysical properties of glycine receptors in rat hypoglossal motoneurons. Soc. Neurosci. Abstr. 23: 651, 1997.
9. BRACCI, E., BALLERINI, L., AND NISTRI, A. Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal spinal cord. J. Neurophysiol. 75: 640-647, 1996.
10. CLEMENTS, J. D. Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci. 19: 163-171, 1996.
11. CLEMENTS, J. D., LESTER, R.A.J., TONG, G., JAHR, C. E., AND WESTBROOK, G. L. The time course of glutamate in the synaptic cleft. Science 258: 1498-1501, 1992.
12. COCHRAN, S. L. Algorithms for detection and measurement of spontaneous events. J. Neurosci. Methods 50: 105-121, 1993.
13. EDMONDS, B., GIBB, A. J., AND COLQUHOUN, D. Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents. Annu. Rev. Physiol. 57: 469-493, 1995.
14. EDWARDS, F. A., KONNERTH, A., AND SAKMANN, B. Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch clamp study. J. Physiol. (Lond.) 430: 213-249, 1990.
15. FABER, D. S., YOUNG, W. S., LEGENDRE, P., AND KORN, H. Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions. Science 258: 1498-1494, 1992.
16. FRERKING, M., BORGES, S., AND WILSON, M. VARIATION IN GABA. mini amplitude is the consequence of variation in transmitter concentration. Neuron 15: 885-895, 1995.
17. FRERKING, M. AND WILSON, M. Saturation of postsynaptic receptors at central synapses? Curr. Opin. Neurobiol. 6: 395-403, 1996.
18. A receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons. J. Neurosci. 17: 7220-7227, 1997.
19. HARTY, T. P. AND MANIS, P. B. Kinetic analysis of glycine receptor currents in ventral cochlear nucleus. J. Neurophysiol. 79: 1891-1901, 1998.
20. HESTRIN, S. Activation and desensitization of glutamate activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron 9: 991-999, 1992.
21. JONAS, P. AND SPRUSTON, N. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr. Opin. Neurobiol. 4: 366-372, 1994.
22. A channel responses to brief agonist pulses. Neuron 15: 181-191, 1995.
23. KALB, R. G. AND HOCKFIELD, S. Electrical activity in the neuromuscular unit can influence the molecular development of motor neurons. Dev. Biol. 162: 539-548, 1994.
24. KIRSCH, J. AND BETZ, H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392: 717-720, 1998.
25. KRUPP, J., LARMET, Y., AND FELTZ, P. Postnatal change of glycinergic IPSC decay in sympathetic preganglionic neurons. NeuroReport 5: 2437-2440, 1994.
26. KUBIN, L., KIMURA, H., TOJIMA, H., DAVIES, R. O., AND PACK, A. I. res Supp.sion of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition. Brain Res. 611: 300-312, 1993.
27. LEGENDRE, P. A reluctant gating mode of glycine receptor channels determines the time course of inhibitory miniature synaptic events in zebrafish hindbrain neurons. J. Neurosci. 18: 2856-2870, 1998.
28. LOWE, A. A. Excitatory and inhibitory inputs to hypoglossal motoneurons and adjacent reticular formation neurons in cats. Exp. Neurol. 62: 30-47, 1978.
29. LOWE, A. A. The neural regulation of tongue movements. Prog. Neurobiol. 15: 295-344, 1980.
30. A receptors open? Neuron 12: 61-71, 1994.
31. MALOSIO, M. L., MARQUEZE-POUEY, B., KUHSE, J., AND BETZ, H. Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J. 10: 2401-2409, 1991.
32. A receptors in cultured murine cerebellar cells. J. Physiol. (Lond.) 503: 353-369, 1997.
33. MELNICK, I. V. AND BAEV, K. V. Glycine conductance changes in chick spinal cord neurons developing in culture. Neuroscience 52: 347-360, 1993.
34. A receptor number underlie variation in GABA mini amplitude. Neuron 19: 697-709, 1997.
35. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18: 1693-1703, 1998.
36. PATON, J.F.R. AND RICHTER, D. W. Role of fast inhibitory synaptic mechanisms in respiratory rhythm generation in the maturing mouse. J. Physiol. (Lond.) 484: 505-521, 1995.
37. PRIOR, P., SCHMIDTT, B., GRENNINGLOH, G., PRIBILLA, I., MULTHAUP, G., BEYREUTHER, K., MAULET, Y., WERNER, P., LANGOSCH, D., KIRSCH, J., AND BETZ, H. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8: 1161-1170, 1992.
38. - currents in Purkinje versus granule neurons in rat cerebellar slices. Neuron 12: 117-126, 1994.
39. REMMERS, J. E., DEGROOT, W. J., SAUERLAND, E. K., AND ANCH, A. M. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 44: 931-938, 1978.
40. ROBINSON, H.P.C., SAHARA, Y., AND KAWAI, N. Nonstationary fluctuation analysis and direct resolution of single channel currents at postsynaptic sites. Biophys. J. 59: 295-304, 1991.
41. ROSENMUND, C. AND WESTBROOK, G. L. Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10: 805-814, 1993.
42. r polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein. Biochemistry 26: 805-811, 1987.
43. SCHMIEDEN, V., KUHSE, J., AND BETZ, H. Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation. EMBO J. 11: 2025-2032, 1992.
44. SIGWORTH, F. J. The variance of sodium current fluctuations at the node of Ranvier. J. Physiol. (Lond.) 307: 97-129, 1980.
45. SINGER, J. H., TALLEY, E. M., BAYLISS, D. A., AND BERGER, A. J. Development of glycinergic synaptic transmission to rat brainstem motoneurons. J. Neurophysiol. 80: 2608-2620, 1998.
46. SOLTESZ, I., SMETTERS, D. K., AND MODY, I. Tonic inhibition originates from synapses close to the soma. Neuron 14: 1273-1283, 1995.
47. SPRUSTON, N., JAFFE, D. B., WILLIAMS, S. H., AND JOHNSTON, D. Voltage- and space-clamp errors associated with the measurement of electrotonically remote synaptic events. J. Neurophysiol. 70: 781-802, 1993.
48. SUMINO, R. AND NAKAMURA, Y. Synaptic potentials of hypoglossal motoneurons and a common inhibitory interneuron in the trigemino-hypoglossal reflex. Brain Res. 73: 439-454, 1974.
49. TAKAHASHI, T. AND MOMIYAMA, A. Single-channel currents underlying glycinergic inhibitory postsynaptic responses in spinal neurons. Neuron 7: 965-969, 1991.
50. TAKAHASHI, T., MOMIYAMA, A., HIRAI, K., HISHINUMA, F., AND AKAGI, H. Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron 9: 1155-1161, 1992.
51. TANG, C. M., MARGULIS, M., SHI, Q. Y., AND FIELDING, A. Saturation of postsynaptic glutamate receptors after quantal release of transmitter. Neuron 13: 1385-1393, 1994.
52. A receptor α6 subunit. J. Neurosci. 16: 3630-3640, 1996.
53. TRAYNELIS, S. F., SILVER, R. A., AND CULL-CANDY, S. G. Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse. Neuron 11: 279-289, 1993.
54. 2+ channels in hypoglossal motoneurons. J. Neurosci. 14: 5652-5660, 1994.
55. WERMAN, R., DAVIDOFF, R. A., AND APRISON, M. H. Inhibitory action of glycine on spinal neurons of the cat. J. Neurophysiol. 31: 81-95, 1967.
56. 3H-strychnine as the ligand. J. Neurosci. 10: 795-812, 1990.
57. WITHINGTON-WRAY, D. J., MIFFLIN, S. W., AND SPYER, K. M. Intracellular analysis of respiratory-modulated hypoglossal motoneurons in the cat. Neuroscience 25: 1041-1051, 1988.