Cobalamin-Dependent Methionine Synthase: Probing the Role of the Axial Base in Catalysis of Methyl Transfer between Methyltetrahydrofolate and Exogenous Cob(I)alamin or Cob(I)inamide

Biochemistry

Volumn 42, Issue 49, 2003, Pages 14653-14662

  Dorweiler, Jeanne Sirovatka ^a,c   Finke, Richard G ^b   Matthews, Rowena G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

^c U S ARMY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYSTS; ENZYMES; FREE ENERGY; RATE CONSTANTS;

LIGANDS;

BIOCHEMISTRY;

5 METHYLTETRAHYDROFOLIC ACID; BENZIMIDAZOLE DERIVATIVE; COBALAMIN; COBINAMIDE; DIMETHYLBENZIMIDAZOLE; HOMOCYSTEINE; LIGAND; METHIONINE SYNTHASE; METHYL GROUP; NUCLEOTIDE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STABILITY; ION TRANSPORT; LIGAND BINDING; PRIORITY JOURNAL; THERMODYNAMICS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; BENZIMIDAZOLES; CATALYSIS; CATIONS; COBAMIDES; MODELS, CHEMICAL; PYRIDINES; QUATERNARY AMMONIUM COMPOUNDS; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET; TETRAHYDROFOLATES; THERMODYNAMICS; VITAMIN B 12;

EID: 0347481132     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035525t     Document Type: Article

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