Providing a chemical basis toward understanding the histidine base-on motif of methylcobalamin-dependent methionine synthase: An improved purification of methylcobinamide, plus thermodynamic studies of methylcobinamide binding exogenous imidazole and pyridine bases

Inorganic Chemistry

Volumn 41, Issue 24, 2002, Pages 6217-6224

  Dorweiler, Jeanne Sirovatka ^a   Matthews, Rowena G ^a   Finke, Richard G ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE S METHYLTRANSFERASE; AMIDE; CYANOCOBALAMIN; DRUG DERIVATIVE; HISTIDINE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; MECOBALAMIN; METHIONINE SYNTHASE; METHYLCOBINAMIDE; NUCLEIC ACID BASE; PYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL MODEL; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHEMISTRY; ENTHALPY; ENTROPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PKA; PURIFICATION; REACTION ANALYSIS; STOICHIOMETRY; SYNTHESIS; TEMPERATURE SENSITIVITY; THERMODYNAMICS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HISTIDINE; IMIDAZOLES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PYRIDINES; THERMODYNAMICS; VITAMIN B 12;

EID: 0037010974     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic010265u     Document Type: Article

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