Mutations in the B12-binding region of methionine synthase: How the protein controls methylcobalamin reactivity

Biochemistry

Volumn 35, Issue 7, 1996, Pages 2464-2475

  Jarrett, Joseph T ^c   Amaratunga, Mohan ^c,d   Drennan, Catherine L ^a,c   Scholten, Jeffrey D ^b   Sands, Richard H ^c   Ludwig, Martha L ^a,c   Matthews, Rowena G ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d GENERAL ELECTRIC COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; CYANOCOBALAMIN; DRUG DERIVATIVE; MECOBALAMIN; 5 METHYLTETRAHYDROFOLIC ACID; ASPARTIC ACID; HISTIDINE; HOMOCYSTEINE; LIGAND; METHIONINE SYNTHASE; SERINE;

AMINO ACID SEQUENCE; ARTICLE; ELECTRON SPIN RESONANCE; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOTOLYSIS; PROTEIN BINDING; AMINO ACID SUBSTITUTION; BACTERIAL GENE; ENZYME MECHANISM; ENZYME STABILITY; ESCHERICHIA COLI; PRIORITY JOURNAL;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; AMINO ACID SEQUENCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PHOTOLYSIS; PROTEIN BINDING; SUBSTRATE SPECIFICITY; VITAMIN B 12;

EID: 0029670933     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952389m     Document Type: Article

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