Hepatitis C NS3 protease inhibition by peptidyl-α-ketoamide inhibitors: Kinetic mechanism and structure

Archives of Biochemistry and Biophysics

Volumn 421, Issue 2, 2004, Pages 207-216

  Liu, Yaya ^a   Stoll, Vincent S ^a   Richardson, Paul L ^a   Saldivar, Ayda ^a   Klaus, Jeffrey L ^a   Molla, Akhteruzzaman ^a   Kohlbrenner, William ^a   Kati, Warren M ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Association rate constant; Conformational changes; Dissociation rate constant; Hepatitis C virus NS3 serine protease; Oxyanion; Peptidyl ketoamide; Slow binding inhibition

Indexed keywords

PEPTIDYL ALPHA KETOAMIDE INHIBITOR; PROTEIN INHIBITOR; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; DRUG SCREENING; ENZYME INHIBITION; ENZYME STRUCTURE; HEPATITIS C VIRUS; KINETICS; NONHUMAN; PRIORITY JOURNAL;

HEPATITIS C VIRUS;

EID: 0347301743     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2003.11.013     Document Type: Article

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