Lecithin-cholesterol acyltransferase (LCAT) as a plasma glycoprotein: An overview

Carbohydrate Polymers

Volumn 55, Issue 2, 2004, Pages 179-191

  Lima, Vera L M ^a   Coelho, Luana C B B ^a   Kennedy, John F ^b   Owen, James S ^c   Dolphin, Peter J ^d  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cholesterol; Lipoproteins; N glycosylation; Serum glycoprotein; Site directed mutagenesis

Indexed keywords

CHOLESTEROL; DISEASES; ENZYMES; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS; PROTEINS; X RAY DIFFRACTION ANALYSIS;

ENZYME SECRETION; OLIGOMER ASSEMBLY;

CARBOHYDRATES;

EID: 0347270353     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2003.09.005     Document Type: Article

References (151)

1. Adimoolam S., Jin L., Grabbe E., Shieh J.J., Jonas A. Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K). Journal of Biological Chemistry. 273:1998;32561-32567.
2. Albers J.J., Adolphson J.L., Chen C.-H. Radioimmunoassay of human plasma lecithin:cholesterol acyltransferase. Journal of Clinical Investigation. 67:1981;141-148.
3. Albers J.J., Tollefson J.H., Chen C.-H., Steinmetz A. Isolation and characterization of human plasma lipid transfer proteins. Arteriosclerosis. 4:1984;49-58.
4. Amri E.Z., Vannier C., Etienne J., Ailhaud G. Maturation and secretion of lipoprotein lipase in cultured adipose cells. II. Effects of tunicamycin on activation and secretion of the enzyme. Biochimica et Biophysica Acta. 875:1986;334-343.
5. Aron L., Jones S., Fielding C.J. Human plasma lecithin: cholesterol acyltransferase (characterization of cofactor-dependent phospholipase activity). Journal of Biological Chemistry. 253:1978;7220-7226.
6. Assmann G., Eckardstein A., Funke H. Lecithin:cholesterol acyltransferase deficiency and fish-eye disease. Current Opinion in Lipidology. 2:1991;110-117.
7. Ayyobi A.F., Lacko A.G., Murray K., Nair M., Li M., Molhuizen H.O., Pritchard P.H. Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source. Biochimica et Biophysica Acta. 1484:2000;1-13.
8. Bagdade J.D., Wagner J.D., Rudel L.L., Clarkson T.B. Accelerated cholesteryl ester transfer and altered lipoprotein composition in diabetic cynomolgus monkeys. Journal of Lipid Research. 36:1995;759-766.
9. Bartalena L., Robbins J. Effect of tunicamycin and monensin on secretion of thyroxine-binding globulin by cultured human hepatoma (Hep G2) cells. Journal of Biological Chemistry. 259:1984;13610-13614.
10. Barter P.J., Hopkins G.J., Gorjatschko L. Comparison of human plasma low and high-density lipoproteins as substrates for lecithin:cholesterol acyltransferase. Biochimica et Biophysica Acta. 792:1984;1-5.
11. Bauer H.C., Parent J.B., Olden K. Role of carbohydrate in glycoprotein secretion by human hepatoma cells. Biochemical and Biophysical Research Communications. 128:1985;368-375.
12. Bielicki J.K., Forte T.M. Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity. Journal of Lipid Research. 40:1999;948-954.
13. Brissette L., Falstrault L. Analysis of the binding and association of human intermediate density lipoproteins to HepG2 cells. Biochimica et Biophysica Acta. 1165:1992;84-92.
14. Buscá R., Pujana M.A., Pognonec P., Auwerx J., Deeb S.S., Reina M., Vilaró S. Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment. Journal of Lipid Research. 36:1995;939-951.
15. Calandra S., Martin M.J., McIntyre N. Plasma lecithin:cholesterol acyltransferase activity in liver disease. European Journal of Clinical Investigation. 1:1971;352-360.
16. Calvo C. Non-enzymatic glycosylation of lipoproteins in the pathogenesis of atherosclerosis in diabetics. Revista Medica de Chile. 125:1997;460-465.
17. Carlson L.A. Fish eye disease: a new familial condition with massive corneal opacities and dyslipoproteinaemia. European Journal of Clinical Investigation. 12:1982;41-53.
18. Carlson L.A., Holmquist L. Evidence for the presence in human plasma of lecithin: cholesterol acyltransferase activity (beta-LCAT) specifically esterifying free cholesterol of combined pre-beta- and beta-lipoproteins. Studies of fish eye disease patients and control subjects. Acta Medica Scandinavica. 218:1985;197-205.
19. Chajek-Shaul T., Friedman G., Knobler H., Stein O., Etienne J., Stein Y. Importance of the different steps of glycosylation for the activity and secretion of lipoprotein lipase in rat preadipocytes studied with monensin and tunicamycin. Biochemical and Biophysical Research Communications. 837:1985;121-134.
20. Chawla D., Owen J.S. Secretion of active human lecithin-cholesterol acyltransferase by insect cells infected with a recombinant baculovirus. Biochemical Journal. 309:1995;249-253.
21. Chen C.-H., Albers J.J. Interspecies activation of lecithin-cholesterol acyltransferase by apolipoprotein A-I isolated from the plasma of humans, horses, sheep, goats and rabbits. Biochimica et Biophysica Acta. 753:1983;40-46.
22. Chen C.-H., Albers J.J. A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma. Biochimica et Biophysica Acta. 834:1985;188-195.
23. Chen C.-H., Forte T.H., Cahoon B.E., Thrift R.N., Albers J.J. Synthesis and secretion of lecithin:cholesterol acyltransferase by the human hepatoma cell line Hep-G2. Biochimica et Biophysica Acta. 877:1986;433-439.
24. Chong K.-S., Hara S., Thompson R.E., Lacko A.G. Characterization of lecithin:cholesterol acyltransferase from human plasma. II. Physical properties of the enzyme. Biochimica et Biophysica Acta. 222:1983;553-560.
25. Cho K.H., Durbin D.M., Jonas A. Role of individual amino acids of apolipoprotein A-I in the activation of lecithin: cholestrol acyltransferase and in HDL rearrangements. Journal of Lipid Research. 42:2001;379-389.
26. Chu F.K., Trimble R.B., Maley F. The effect of carbohydrate depletion on the properties of yeast external invertase. Journal of Biological Chemistry. 253:1978;8691-8693.
27. Chung J., Abano D.A., Fless G.M., Scanu A.M. Isolation, properties and mechanism of in vitro action of lecithin:cholesterol acyltransferase from human plasma. Journal of Biological Chemistry. 254:1979;7456-7464.
28. Cohen L.H., Griffoen M., Havekes L., Schouten D., Van-Hinsberg V., Kempen H.J. Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2. Biochemical Journal. 222:1984;35-39.
29. Collet X., Fielding C.J. Effects of inhibitors of N-linked oligosaccharide processing on the secretion, and stability of lecithin: cholesterol acyltransferase. Biochemistry. 30:1991;3228-3234.
30. Craig W.Y. The effect of compounds associated with cigarette smoking on the secretion of lipoprotein lipid by HepG2 cells. Biochimica et Biophysica Acta. 1165:1993;249-258.
31. De Parscau L., Fielding P.E. Lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity from the isolated perfused rabbit liver. Journal of Lipid Research. 25:1984;721-728.
32. Doi Y., Nishida T. Lecithin-cholesterol acyltransferase from human plasma. Methods in Enzymololgy. 71:1981;753-767.
33. Doi Y., Nishida T. Microheterogeneity and physical properties of human lecithin:cholesterol acyltransferase. Journal of Biological Chemistry. 258:1983;5840-5846.
34. Dolphin P.J. Lipolytic enzymes and the role of apolipoproteins in the regulation of their activity. Rosseneu M. Structure and function of lipoproteins. 1992;295-362 CRC Press, Boca Raton, FL.
35. Dwek R.A. Glycobiology: towards understanding the function of sugars. Biochemical Society Transactions. 23:1995;1-25.
36. Elbein A.D. Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains. Annual Reviews in Biochemistry. 56:1987;497-534.
37. Erickson S.K., Fielding P.E. Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2. Journal of Lipid Research. 27:1986;875-883.
38. Farooqui J.Z., Wohl R.C., Kezdy F.J., Scanu A.M. Identification of the active-site serine in human lecithin: cholesterol acyltransferase. Archives of Biochemistry and Biophysics. 216:1988;330-335.
39. Fielding C.J., Fielding P.E. Molecular physiology of reverse cholesterol transport. Journal of Lipid Research. 36:1995;211-228.
40. Fielding C.J., Shore V.G., Fielding P.E. A protein cofactor of lecithin:cholesterol acyltransferase. Biochemical and Biophysical Research Communications. 46:1972;1493-1498.
41. Francone O.L., Evangelista L., Fielding C.J. Lecithin-cholesterol acyltransferase: effects of mutagenesis at N-linked oligosaccharide attachment sites on acyl acceptor activity. Biochimica et Biophysica Acta. 1166:1993;301-304.
42. Francone O.L., Evangelista L., Fielding C.J. Effects of carboxy-terminal truncation on human lecithin: cholesterol acyltransferase activity. Journal of Lipid Research. 37:1996;1609-1615.
43. Francone O.L., Fielding C.J. Structure-function relationships in human lecithin:cholesterol acyltransferase. Site-directed mutagenesis at serine residues 181 and 216. Biochemistry. 30:1991;10074-10077.
44. Francone O.L., Gurakar A., Fielding C.J. Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol. Journal of Biological Chemistry. 264:1989;7066-7072.
45. Fruchart J.C., Duriez P. Reverse cholesterol transport and use of transgenic mice and rabbits to reveal candidate genes for protection against atherosclerosis. Bulletin de l'Academie Nationale de Medecine. 182:1998;233-247.
46. Fuhrmann U., Bause E., Legler G., Ploegh H. Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides. Nature. 307:1984;755-758.
47. Fukuda M. Cell surface carbohydrates: Cell-type specific expression. Fukuda M., Hindsgaul O. Molecular glycobiology. 1994;1-52 IRL Press, New York.
48. Funke H., von Eckardstein A., Pritchard P.H., Hornby A.E., Wiebusch H., Motti C., Hayden M.R., Dachet C., Jacotot B., Gerdes U., Faergeman O., Albers J.J., Colleoni N., Catapano A., Frohlich J., Assmann G. Genetic and phenotypic heterogeneity in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: six newly identified defective alleles further contribute to structural heterogeneity in this disease. Journal of Clinical Investigation. 91:1993;677-683.
49. Gebhart A.M., Ruddon R.W. What regulates secretion of non-stored proteins by eukaryotic cells? Bioessays. 4:1986;213-218.
50. Gibson R., Kornfeld S., Schlesinger S. A role for oligosaccharides in glycoprotein synthesis. Trends in Biochemical Sciences. 5:1980;290-293.
51. Gillett M.P.T. Comparative studies of the lecithin:cholesterol acyltransferase reaction in the plasma of reptiles and amphibians. Scandinavian Journal of Clinical and Laboratory Investigation. 38:(Suppl 150):1978;32-39.
52. Gillett M.P.T., Lima V.L.M., Costa J.C.M., Sibrian A.M.K. Plasma lipid concentration for some Brazilian lizards. Comparative Biochemistry and Physiology. 64B:1979;273-277.
53. Gillett M.P.T., Lima-Filho A.B., Lima-Filho J.L., Lima V.L.M. Relationship between plasma lipid and lipoprotein levels and lecithin:cholesterol acyltransferase activity in non-laying domestic hens. Gallus domesticus. Arquivos do Instituto Biologico. 27:1984;329-337.
54. Glomset J.A. The mechanism of the plasma cholesterol esterification reaction: plasma fatty acid transferase. Biochimica et Biophysica Acta. 65:1962;128-135.
55. Glomset J.A. The plasma lecithin:cholesterol acyltransferase reaction. Journal of Lipid Research. 9:1968;155-167.
56. Glomset J.A., Assmann E.G., Gjone E., Norum K.R. Lecithin:cholesterol acyltransferase deficiency and fish eye disease. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The metabolic and molecular bases of inherited disease. 1995;1933-1951 McGraw-Hill, New York.
57. Gotoda T., Yamada N., Murase T., Sakuma M., Murayama N., Shimano H., Kozaki K., Albers J.J., Yazaki Y., Akanuma Y. Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency. Lancet. 338:1991;778-781.
58. Guérin M., Dachet C., Goulinet S., Chevet D., Dolphin P.J., Chapman M.J., Rouis M. Familial lecithin:cholesterol acyltransferase deficiency: molecular analysis of a compound heterozygote: LCAT (Arg147→Trp) and LCAT (Tyr171→Stop). Atherosclerosis. 131:1997;85-95.
59. Guérin M., Dolphin P.J., Chapman M.J. A new in vitro method for the simultaneous evaluation of cholesteryl ester exchange and mass transfer between HDL and apoB-containing lipoprotein subspecies. Identification of preferential cholesteryl ester acceptors in human plasma. Arteriosclerosis and Thrombosis. 14:1994;199-206.
60. Hayashi K., Kurokawa J.-I., Nomura S., Kuga Y., Ohkura Y., Kajiyama G. Effect of fluvastatin sodium (XU62-320), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on the induction of low-density lipoprotein receptor in HepG2 cells. Biochimica et Biophysica Acta. 1167:1993;223-225.
61. Hengstschlager-Ottnad E., Kuchler K., Schneider W.J. Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern. Journal of Biological Chemistry. 270:1995;26139-26145.
62. Hickman S., Kulczycki A. Jr., Lynch R.G., Kornfeld S. Studies of the mechanism of tunicamycin inhibition of IgA and IgE secretion by plasma cells. Journal of Biological Chemistry. 252:1977;4402-4408.
63. Hill J.S., O K., Wang X., Paranjape S., Dimitrijavich D., Lacko A.G., Pritchard P.H. Expression and characterization of recombinant human lecithin:cholesterol acyltransferase. Journal of Lipid Research. 34:1993;1245-1251.
64. Hill J.S., O K., Wang X., Pritchard P.H. Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism. Biochimica et Biophysica Acta. 1181:1993;321-323.
65. Hixson J.E., Driscoll D.M., Birnbaum S., Britten M.L. Baboon lecithin cholesterol acyltransferase (LCAT): cDNA sequences of two alleles, evolution, and gene expression. Gene. 128:1993;259-299.
66. Holmquist L., Bjellqvist B. Microheterogeneity of human plasma lecithin:cholesterol acyltransferase examined by isoelectric focusing in immobilized pH gradients. Electrophoresis. 9:1988;580-582.
67. Horie M., Hayashi M., Satoh T., Hotta S., Nagata Y., Ishida F., Kamei T. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol an simultaneously reduces apolipoprotein B in HepG2 cells. Biochimica et Biophysica Acta. 1168:1993;45-51.
68. Horton R.C., Owen J.S. LCAT activity as a prognostic liver function test. Lancet. 336:1990;249-250.
69. Humphries S.E., Chaves M.E., Tata F., Lima V.L.M., Owen J.S., Borysiewicz L.K., Catapano A., Vergani C., Gjone E., Clemens M.R., Williamson R., McIntyre N. A study of the structure of the gene for LCAT in four unrelated individuals with familial lecithin: cholesterol acyltransferase deficiency. Clinical Sciences. 74:1988;91-96.
70. Jauhiainen M., Dolphin P.J. Human plasma lecithin-cholesterol acyltransferase. An elucidation of the catalytic mechanism. Journal of Biological Chemistry. 261:1986;7032-7043.
71. Jauhiainen M., Dolphin P.J. Human plasma lecithin:cholesterol acyltransferase (LCAT). On the role of essential carboxyl groups in catalysis. Advances in Experimental Medicine and Biology. 285:1990;71-75.
72. Jauhiainen M., Ridgway N.D., Dolphin P.J. Aromatic boronic acids as probes of the catalytic site of human plasma lecithin-cholesterol acyltransferase. Biochimica et Biophysica Acta. 918:1987;175-188.
73. Jenkins N., Parekh R.B., James D.C. Getting the glycosylation right: implications for the biotechnology industry. Nature Biotechnology. 14:1996;975-981.
74. Kennedy J.F., Palva P.M.G., Corella M.T.S., Cavalcanti M.S.M., Coelho L.C.B.B. Lectins, versatile proteins of recognition. A review. Carbohydrate Polymers. 26:1995;219-230.
75. Knipping G., Birchbauer A., Stevrer E., Groener J., Zechner R., Kostner G.M. Studies on the substrate specificity of human and pig lecithin: cholesterol acyltransferase: role of low-density lipoproteins. Biochemistry. 25:1986;5242-5249.
76. Kornfeld R. Structure of glycoprotein oligosaccharides. Popper H., Rutter W., Gudat F., Kottgen E. Structural carbohydrates in the liver. 1983;13-22 MTP Press, Lancaster.
77. Kosman J., Jonas A. Deletion of specific glycan chains affects differentially the stability, local structures, and activity of lecithin-cholestrol acyltransferase. Journal of Biological Chemistry, 276. 2001.
78. Kuivenhoven J.A., Pritchard H., Hill J., Frohlich J., Assmann G., Kastelein J. The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. Journal of Lipid Research. 38:1997;191-205.
79. Labiola C., Cazzulo J.J., Parodi A.J. Retention of glucose units added by the UDP-GLC:glycoprotein glucosyltransferase delays exit of glycoproteins from the endoplasmic reticulum. Journal of Cell Biology. 130:1995;771-779.
80. Lacko A.G., Reason A.J., Nuckolls C., Kudchodkar B.J., Nair M.P., Sundarrajan G., Pritchard P.H., Morris H.R., Dell A. Characterization of recombinant human plasma lecithin:cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties. Journal of Lipid Research. 39:1998;807-820.
81. Lacko A.G., Rutenberg H.L., Soloff L.A. Serum cholesterol esterification in species resistant and susceptible to atherosclerosis. Atherosclerosis. 19:1974;297-305.
82. Lennarz W. Role of intracellular membrane systems in glycosylation of proteins. Methods in Enzymology. 98:1983;91-97.
83. Lima, V. L. M (1989). Polyclonal antibodies to human plasma lecithin:cholesterol acyltransferase. PhD thesis. University of London.
84. Lima V.L.M., Cannizzaro H.M., Owen J.S. Isolation and preliminary microheterogeneity studies of lecithin-cholesterol acyltransferase in plasma from individual patients infected with Schistosoma mansoni. International Hepatology Communications. 6:1997;300-305.
85. Lima V.L.M., Correia M.T.S., Cechinel Y.M.N., Sampaio C.A.M., Owen J.S., Coelho L.C.B.B. Immobilized Cratylia mollis lectin as a potential matrix to isolate plasma glycoproteins, including lecithin-cholesterol acyltransferase. Carbohydrate Polymers. 33:1997;27-32.
86. Lima V.L.M., Harry D.S., McIntyre N., Owen J.S., Chaves M.E.C. Characterization and potential uses of rabbit polyclonal antibodies against human plasma lecithin-cholesterol acyltransferase. Brazilian Journal of Medical and Biological Research. 29:1996;957-968.
87. Lima V.L.M., Harry D.S., Owen J.S., McIntyre N. Polyclonal antibodies to human plasma lecithin:cholesterol acyltransferase. Biochemical Society Transactions. 15:1987;477-478.
88. Lima V.L.M., McIntyre N., Owen J.S. Secretion of lecithin:cholesterol acyltransferase (LCAT) by the human hepatoma cell line, HepG-2. Biochemical Society Transactions. 16:1988;155-156.
89. Lima V.L.M., McIntyre N., Owen J.S. Secretion of lecithin:cholesterol acyltransferase (LCAT) by cultured human hepatoblastoma cell lines. Journal of Hepatology. 7:1988;S52.
90. Lima V.L.M., Sena V.L.M., Stewart B., Owen J.S., Dolphin P.J. An evaluation of the marmoset Callithrix jacchus (sagüi) as an experimental model for the dyslipoproteinemia of human Schistosomiasis mansoni. Biochimica et Biophysica Acta. 1393:1998;235-243.
91. Lodish H.F., Kong N., Snider M., Strous G.J.A.M. Hepatoma secretory proteins migrate from rough endoplasmic reticulum to golgi at characteristic rates. Nature. 304:1983;80-83.
92. Maeda E., Naka Y., Matozaki T., Sakuma M., Akanuma Y., Yoshino G., Kasuga M. Lecithin-cholesterol acyltransferase (LCAT) deficiency with a missense mutation in exon 6 of the LCAT gene. Biochemical and Biophysical Research Communications. 178:1991;460-466.
93. Masuno H., Schultz G.J., Park J.-W., Blanchette-Mackie E.J., Mateo C., Scow R.O. Glycosylation, activity and secretion of lipoprotein lipase in cultured brown adipocytes of newborn mice. Effect of tunicamycin, monensin, 1-deoxymannojirimycin and swainsonine. Biochemical Journal. 277:1991;801-809.
94. Mazzone T., Papagiannes E., Magner T. Early kinetics of human macrophage apolipoprotein E synthesis and incorporation of carbohydrate precursors. Biochimica et Biophysica Acta. 875:1986;393-396.
95. McIntyre N. Familial LCAT deficiency and fish-eye disease. Journal of Inherited Metabolic Disease. 11:1988;45-56.
96. McLean J., Fielding C., Drayna D., Dieplinger H., Baer B., Kohr W., Henzel W., Lawn R. Cloning and expression of human lecithin: cholesterol acyltransferase cDNA. Proceedings of the National Academy of Sciences USA. 83:1986;2335-2339.
97. Meroni G., Malgaretti N., Magnaghi P., Taramelli R. Nucleotide sequence of the cDNA for lecithin:cholesterol acyltransferase (LCAT) from rat. Nucleic Acids Research. 18:1990;5308.
98. Miettinen H., Gylling H., Ulmanen I., Miettinen T.A., Kontula K. Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency. Arteriosclerosis,Tthrombosis, and Vascular Biology. 15:1995;462-467.
99. Miller K.R., Wang J., Sorci-Thomas M., Anderson R.A., Parks J.S. Glycosylation structure and enzyme activity of lecithin:cholesterol acyltransferase from human plasma, HepG2 cells, and baculoviral and Chinese hamster ovary cell expression systems. Journal of Lipid Research. 37:1996;551-561.
100. Montreuil J., Bouquelet S., Debray H., Lemoine J., Michalski J.-C., Spik G., Strecker G. Glycoproteins. Chaplin M.F., Kennedy J.F. Carbohydrate analysis: A practical approach. 1994;181-293 IRL Press, Oxford.
101. Moriyama K., Sasaki J., Arakawa F., Takami N., Maeda E., Matsunaga A., Takada Y., Midorikawa K., Yanase T., Yoshino G., Marcovina S.M., Albers J.J., Arakawa K. Two novel point mutations in the lecithin: cholesterol acyltransferase (LCAT) gene resulting in LCAT deficiency: LCAT (G873 deletion) and LCAT (Gly344→Ser). Journal of Lipid Research. 36:1995;2329-2343.
102. Murata Y., Maeda E., Yoshino G., Kasuga M. Cloning of rabbit LCAT cDNA: increase in LCAT mRNA abundance in the liver of cholesterol-fed rabbits. Journal of Lipid Research. 37:1996;1616-1622.
103. Nishida H.I., Kato H., Nishida T. Affinity of lipid transfer protein for lipid and lipoprotein particles as influenced by lecithin: cholesterol acyltransferase. Journal of Biological Chemistry. 265:1990;4876-4883.
104. Nordby G., Berg T., Nilsson M., Norum K.R. Secretion of lecithin:cholesterol acyltransferase from isolated rat hepatocytes. Biochimica et Biophysica Acta. 450:1976;69-77.
105. O K., Hill T.S., Pritchard P.H. Role of N-linked glycosylation of lecithin:cholesterol acyltransferase in lipoprotein substrate specificity. Biochimica et Biophysica Acta. 1254:1995;193-197.
106. O K., Hill J.S., Wang X., McLeod R., Pritchard P.H. Lecithin:cholesterol acyltransferase: role of N-linked glycosylation in enzyme function. Biochemical Journal. 294:1993;879-884.
107. Olden K., Bernard B.A., Humphries M.J., Yeo T.-K., Yeo K.T., White S.L., Newton S.A., Bauer H.C., Parent J.B. Function of glycoprotein glycans. Trends in Biochemical Sciences. 10:1985;78-82.
108. Olden K., Pratt R.M., Yamada K.M. Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Cell. 13:1978;461-473.
109. Olivecrona T., Chernick S.S., Bengtsson-Olivecrona G., Garrison M., Scow R.O. Synthesis and secretion of lipoprotein lipase in 3T3-L1 adipocytes. Demonstration of inactive forms of lipase in cells. Journal of Biological Chemistry. 262:1987;10748-10759.
110. Osuga T., Portman O.W. Origin and disappearance of plasma lecithin:cholesterol acyltransferase. American Journal of Physiology. 220:1971;735-741.
111. Owen J.S. Plasma lipoproteins and the regulation of cellular function. Reid E., Cook G.M.W., Moore D.J. Methodological surveys in biochemistry and analysis. Investigation of membrane-located receptors. Vol. 13:1984;311-316 Plenum Press, New York.
112. Owen J.S., McIntyre N. Plasma lipoprotein metabolism and lipid transport. Trends in Biochemical Sciences. 7:1982;95-98.
113. Owen J.S., Wiebusch H., Cullen P., Watts G.F., Lima V.L.M., Funke H., Assmann G. Complete deficiency of plasma lecithin-cholesterol acyltransferase (LCAT) activity due to a novel homozygous mutation (Gly-30-Ser) in LCAT gene. Human Mutations. 8:1996;79-82.
114. Paulson J.C. Glycoproteins: what are the sugar chains for? Trends in Biochemical Sciences. 14:1989;272-276.
115. Paulson J.C., Colley K.J. Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation. Journal of Biological Chemistry. 264:1989;17615-17618.
116. Peelman F., Vanloo B., Perez-Mendez O., Decout A., Verschelde J.L., Labeur C., Vinaimont N., Verhee A., Duverger N., Brasseur A. Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT). Protein Engineering. 12:1999;71-78.
117. Peelman F., Vinaimont N., Verhee A., Vanloo B., Verschelde J.-L., Labeur C., Seguret-Mace S., Duverger N., Hutchinson G., Vandekerckhove J., Tavernier J., Rosseneu M. A proposed architecture for lecithin cholesterol acyl transferase (LCAT): identification of the catalytic triad and molecular modelling. Protein Science. 7:1998;587-599.
118. Peters B.P., Krzesicki R.F., Perini F., Huddon R.W. The effect of carbonyl cyanide trifluoromethoxyphenylhydrazone and methylamine on the processing and secretion of the glycoprotein hormone chorionic gonadotropin by human choriocarcinoma cells. Endocrinology. 119:1986;416-428.
119. Piran U., Nishida T. Utilization of various sterols by lecithin-cholesterol acyltransferase as acyl acceptors. Lipids. 14:1979;478-482.
120. Qu S.-J., Fan H.-Z., Vaca F.B., Pownall H.J. Effects of site-directed mutagenesis on the N-glycosylation sites of human lecithin:cholesterol acyltransferase. Biochemistry. 32:1993;8732-8736.
121. Ridgway N.D., Dolphin P.J. Serum activity and hepatic secretion of lecithin: cholesterol acyltransferase in experimental hypothyroidism and hypercholesterolemia. Journal of Lipid Research. 26:1985;1300-1313.
122. Roosbeek S., Vanloo B., Duverger N., Caster H., Breyne J., De Beun I., Patel H., Vandekerckhove J., Shoulders C., Rosseneu M. Three arginine residues in apolipoprotein A-I are critical for activation of lecithin: cholesterol acyltransferase. Journal of Lipid Research. 42:2001;31-40.
123. Rothblat G.H., de la Llera-Moya M., Atger V., Kellner-Weibel G., Williams D.L., Philips M.C. Cell cholesterol efflux: integration of old and new observations provides new insights. Journal of Lipid Research. 40:1999;781-796.
124. Rothblat G.H., Mahlberg F.H., Johnson W.J., Philips M.C. Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux. Journal of Lipid Research. 33:1992;1091-1097.
125. Rye K.-A., Barter P.J. Lipid transfer activities and apolipoproteins. Rosseneu M. Structure and function of lipoproteins. 1992;401-426 CRC Press, Boca Raton, FL.
126. Schachter H. Molecular cloning of glycosyltransferase genes. Fukuda M., Hindsgaul O. Molecular glycobiology. 1994;88-162 IRL Press, New York.
127. Schindler P.A., Settineri C.A., Collet X., Fielding C.J., Burlingame A.L. Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion. Protein Science. 4:1995;791-803.
128. 2 interconversion. Clinica Chimica Acta. 119:1982;225-236.
129. Schwartz A.L., Fridovitch S.E., Lodish H.F. Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line. Journal of Biological Chemistry. 257:1982;4230-4237.
130. Sharon N. Glycoproteins. Trends in Biochemical Sciences. 9:1984;198-202.
131. Simsolo R.B., Ong J.M., Kern P.A. Characterization of lipoprotein lipase activity, secretion, and degradation at different sites of post-translational processing in primary cultures of rat adipocytes. Journal of Lipid Research. 33:1992;1777-1784.
132. Smith K.M., Lawn R.M., Wilcox J.N. Cellular localization of apolipoprotein D and lecithin:cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridisation. Journal of Lipid Research. 31:1990;995-1004.
133. Soler-Argilaga C., Russel R., Goh E.H., Heimberg M. Hepatic secretion and turnover of serum phosphatidylcholine-cholesterol acyltransferase in male and female rats. Biochimica et Biophysica Acta. 488:1977;69-75.
134. Sorci-Thomas M., Babiak J., Rudel L.L. Lecithin-cholesterol acyltransferase (LCAT) catalyses transacylation of intact cholesteryl esters. Evidence for the partial reversal of the forward LCAT reaction. Journal of Biological Chemistry. 265:1990;2665-2670.
135. Stokke K.T., Fjeld N.B., Kluge T.H., Skrede S. Lipid composition and cholesterol esterification in lymph. Scandinavian Journal of Clinical and Laboratory Investigation. 33:1974;199-206.
136. Struck D.K., Lennarz W.J. The function of saccharide-lipids in synthesis of glycoproteins. Lennarz W.J. Biochemistry of glycoproteins and proteoglycans. 35-83:1980;35-83 Plenum Press, New York.
137. Struck D.K., Suita P.B., Lane M.D., Lennarz W.J. Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin. Journal of Biological Chemistry. 253:1978;5332-5337.
138. Subbaiah P.V., Bagdade J.D. Demonstration of enzymatic conversion of lysolecithin to lecithin in normal plasma. Life Sciences. 22:1978;1971-1977.
139. Tarentino A.L., Plummere T.H. Jr. Enzymatic deglycosylation of asparagine-linked glycans: purification, properties, and specificity of oligosaccharide-cleaving enzymes from Flavobacterium meningosepticum. Methods in Enzymology. 230:1994;44-57.
140. Tartakoff A.M. Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell. 32:1983;1026-1028.
141. Tata F., Chaves M.E.C., Markham A.F., Scrace G.D., Waterfield M.D., McIntyre N., Williamson R., Humphries S.E. The isolation and characterization of cDNA and genomic clones for human lecithin: cholesterol acyltransferase. Biochimica et Biophysica Acta. 910:1987;142-148.
142. Tkacz J.S., Lampen J.O. Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes. Biochemical and Biophysical Research Communications. 65:1975;248-257.
143. Trimble R.B., Tarentino A.L. Identification of distinct endoglycosidase (endo) activities in Flavobacterium meningosepticum: endo F1, endo F2, and endo F3. Endo F1 and endo H hydrolyze only high mannose and hybrid glycans. Journal of Biological Chemistry. 266:1991;1646-1651.
144. Tulsiani D.R.P., Harris T.M., Touster O. Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. Journal of Biological Chemistry. 257:1982;7936-7939.
145. Turner G.A. N-glycosylation of serum proteins in disease and its investigation using lectins. Clinica Chimica Acta. 208:1992;149-171.
146. Uchida N., Smilowitz H., Tanzer M.L. Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts. Proceedings of the National Academy of Sciences USA. 76:1979;1868-1872.
147. Utermann G., Menzel H.-J., Adler G., Dieker P., Weber W. Substitution in vitro of lecithin-cholesterol acyltransferase. Analysis of changes in plasma lipoproteins. European Journal of Biochemistry. 107:1980;225-241.
148. Warden C.H., Langner C.A., Gorden J.I., Taylor B.A., McLean J.W., Lusis A.J. Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin-cholesterol acyltransferase gene: evidence for expression in brain and testes as well as liver. Journal of Biological Chemistry. 264:1989;21573-21581.
149. Williamson A.R., Singer H.H., Singer P.A., Mosmann T.R. The value of tunicamycin for studies on immunoglobulin biosynthesis. Biochemical Society Transactions. 8:1980;168-170.
150. Yang C.-Y., Manoogian D., Pao Q., Lee F.-S., Knapp R.D., Gotto A.M. Jr., Pownall H.J. Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme. Journal of Biological Chemistry. 262:1987;3086-3091.
151. Zhou G., Dolphin P.J. Human plasma lecithin:cholesterol acyltransferase. On the substrate efficiency of cholest-5-ene-3(-thiol as a fatty acyl acceptor. Biochimica et Biophysica Acta. 1258:1995;101-106.