Overexpression of DNA polymerase β sensitizes mammalian cells to 2',3'- deoxycytidine and 3'-azido-3'-deoxythymidine

Cancer Research

Volumn 57, Issue 1, 1997, Pages 110-116

  Bouayadi, Khalil ^a   Hoffmann, Jean Sébastien ^b   Fons, Pascal ^a   Tiraby, Michele ^c   Reynes, Jean Paul ^c   Cazaux, Christophe ^a,b  

^a UPS   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c CAYLA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA DIRECTED DNA POLYMERASE BETA; THYMIDINE KINASE; ZALCITABINE; ZIDOVUDINE; ZIDOVUDINE 5' TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; GENE OVEREXPRESSION; MAMMAL CELL; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION;

ANIMALS; CHO CELLS; CRICETINAE; DEOXYCYTIDINE; DNA POLYMERASE I; DNA REPLICATION; MELANOMA, EXPERIMENTAL; NEOPLASM PROTEINS; THYMIDINE KINASE; TRANSFECTION; ZIDOVUDINE;

EID: 0031034761     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kornberg, A., and Baker, T. Eukaryotic DNA polymerases. DNA Replication, 2nd ed, pp. 197-225. New York: W. H. Freeman, 1992.
2. Sobol, R. W., Horton, J. K., Kühn, R., Gu, H., Singhal, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature (Lond.), 379: 183-186, 1996.
3. Jenkins, T. M., Saxena, J. K., Kumar, A., Wilson, S. H., and Ackerman, E. J. DNA polymerase β and DNA synthesis in Xenopus oocytes and in a nuclear extract. Science (Washington DC), 258: 475-478, 1992.
4. Sweasy, J. B., and Loeb, L. Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in Escherichia coli. J. Biol. Chem., 267: 1407-1410, 1992.
5. Hoffmann, J. S., Pillaire, M. J., Maga, G., Podust, V., Hübscher, U., and Villani, G. DNA polymerase β bypass in vitro d(GpG)-cisplatin adduct placed on codon 13 of H-ras gene. Proc. Natl. Sci. USA, 92: 5356-5360, 1995.
6. Zmudzka, B. Z., Fornace, A., Collins, J., and Wilson, S. H. Characterisation of DNA polymerase β mRNA: cell-cycle and growth response in cultured human cells. Nucleic Acids Res., 16: 9589-9596, 1988.
7. Srivastava, D. K., Rawson, T. Y., Showalter, S. D., and Wilson, S. H. Phorbol ester abrogates up-regulation of DNA polymerase β by DNA-alkylating agents in Chinese hamster ovary cells. J. Biol. Chem., 270: 16402-16408, 1995.
8. Fornace, A. J., Zmudzka, B., Hollander, M. C., and Wilson, S. H. Induction of β-polymerase mRNA by DNA damaging agents in Chinese hamster ovary cells. Mol. Cell. Biol., 9: 851-853, 1989.
9. Kunkel, T. A. Frameshift mutagenesis by eukaryotic DNA polymerases in vitro. J. Biol. Chem., 261: 13581-13587, 1986.
10. Copeland, W. C., Chen, M. S., and Wang, T. S. F. Human DNA polymerases α and β are able to incorporate anti-HIV deoxynucleotides into DNA. J. Biol. Chem., 267: 21459-21464, 1992.
11. Parker, W. B., White, E. L., Shaddix, S. C., Ross, L. J., Buckheit, R. W., Germany, J. M., Secrist, J. A., Vince, R., and Shannon, W. M. Mechanisms of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α, β, and γ by the 5′-triphosphates of carbovir: 3′-azido-3′-deoxythymidine,2′,3′-dideoxyguanosine, and 3′-deoxythymidine. J. Biol. Chem., 266: 1754- 1762, 1991.
12. Sommadossi, J. P., Carlisle, R., and Zhou, Z. Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells. Mol. Pharmacol., 36: 9-14, 1989.
13. Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Lehrman, S. N., Bolognesi, D. P., Broder, S., and Mitsuya, H. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, 83: 8333-8337, 1986.
14. Neuhard, D. J., and Nygaard, P. Biosynthesis and conversions of nucleotides: purines and pyrimidines. In: F. C. Neidhart, J. C. Ingraham, K. B. Low, B. Magasanik, M. Schaecter, and H. E. Umbarger (eds.), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, pp. 445-473. Washington, DC: American Society for Microbiology, 1987.
15. Drocourt, D., Calmels, T., Reynes, J. P., Baron, M., and Tiraby, G. Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance. Nucleic Acids Res., 18: 4009, 1990.
16. Reynes, J. P., Tiraby, M., Baron, M., Drocourt, D., and Tiraby, G. Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence and genetic organization of the corresponding tmk locus. J. Bacteriol., 178: 2804-2812, 1996.
17. Kohara, Y., Akiyama, K., and Isono, K. The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library. Cell, 50: 495-508, 1987.
18. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M., and Arai, N. SRalpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol., 8: 466-472, 1988.
19. Daws, T. D., and Fuchs, J. A. Isolation and characterization of an Escherichia coli mutant deficient in dTMP kinase activity. J. Bacteriol., 157: 440-444, 1984.
20. Kawai, S., and Nishizawa, M. New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol. Cell. Biol., 4: 1172-1174, 1984.
21. Pressacco, J., Mitrovski, B., Erlichman, C., and Hedley, D. W. Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression. Cancer Res., 55: 1505-1508, 1995.
22. Culver, K. W., Van Gilder, J., Link, C. J., Carlstrom, T., Buroker, T., Yuh, W., Koch, K., Schabold, K., Doornbas, S., and Wetjen, B. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum. Gene Ther., 5: 343-379, 1994.
23. Moolten, F. L., and Wells, J. M. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst., 82: 297-300, 1990.
24. Huber, B. E., Richards, C. A., and Krenitsky, T. A. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc. Natl. Acad. Sci. USA, 88: 8039-8043, 1991.
25. Vile, R. G., and Hart, I. A. Use of tissue-specific expression of the of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 53: 3860-3864, 1993.
26. Amundson, S. A., and Liber, H. L. A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants. Mutat. Res., 267: 89-95, 1992.
27. + cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. Proc. Natl. Acad. Sci. USA, 89: 182-186, 1992.
28. Thomas, K. R., and Capecchi, M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 51: 503-512, 1987.