Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes ™): Application to the chiral metabolism of mephenytoin and methadone

Electrophoresis

Volumn 24, Issue 15, 2003, Pages 2577-2587

  Prost, Francine ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Caffeine; Chiral capillary electrophoresis; CYP450; Dextromethorphan; Diclofenac; In vitro drug metabolism; Mephenytoin; Methadone

Indexed keywords

CAPILLARY ELECTROPHORESIS; ENZYMES; LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; PHYSIOLOGY; STEREOSELECTIVITY;

CHIRAL CAPILLARY ELECTROPHORESIS; CYP450 ENZYMES; DEXTROMETHORPHAN; DICLOFENAC; DRUG METABOLISMS; IN VITRO DRUG METABOLISM; IN-VITRO; MEPHENYTOIN; METHADONE; MULTIWAVELENGTH;

CAFFEINE;

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; DRUG METABOLITE; MEPHENYTOIN; METHADONE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CAPILLARY ELECTROPHORESIS; CATALYSIS; CHIRALITY; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME SUBSTRATE; IN VITRO STUDY; INSECT CELL; LIVER MICROSOME; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; NONHUMAN; PHARMACOKINETICS; PHENOTYPE; PROTEIN EXPRESSION; RACEMIC MIXTURE; STEREOCHEMISTRY; ZONE ELECTROPHORESIS;

EID: 0347004734     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.200305493     Document Type: Article

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