Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a Type II diabetic rat model

Diabetologia

Volumn 45, Issue 3, 2002, Pages 402-415

  Jesmin, S ^a   Sakuma, I ^a   Hattori, Y ^a   Fujii, S ^a   Kitabatake, A ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenic growth factors; Calcium channel blocker; Cardiac remodelling; Coronary capillary network; Coronary endothelial cell apoptosis; Otsuka Long Evans Tokushima Fatty rat; Type II diabetes mellitus

Indexed keywords

ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; BENIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; COLLAGEN; LONG ACTING DRUG; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; ENDOTHELIUM CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MORPHOMETRICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CAPILLARIES; COLLAGEN; CORONARY VESSELS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; LYMPHOKINES; MALE; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036202678     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-001-0765-6     Document Type: Article

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