Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum

Urological Research

Volumn 26, Issue 2, 1998, Pages 129-135

  Bloch, Wilhelm ^a   Klotz, Theodor ^a   Sedlaczek, Peter ^a   Zumbé, Jürgen ^a   Engelmann, Udo ^a   Addicks, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

eNOS; Erectile dysfunction; Nitrinergic innervation; nNOS; Smooth muscle

Indexed keywords

NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ADULT; ARTERY MUSCLE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE INNERVATION; PENIS ERECTION; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY;

HUMANS; IMMUNOHISTOCHEMISTRY; IMPOTENCE; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PENILE ERECTION; PENIS;

EID: 0031978604     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002400050035     Document Type: Article

References (21)

1. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768
2. Brock G, Nunes L, Padma-Nathan H, Boyd S, Lue TF (1993) Nitric oxide synthase: a new diagnostic tool for neurogenic impotence Urology 42:412
3. Burnett AL, Lowenstein CJ, Bredt DS, Chang TSK, Snyder SH (1992) Nitric oxide: a physiologic mediator of the penile erection. Science 257:401
4. Burnett AL (1995) Role of nitric oxide in the physiology of erection. Biol Reprod 52:485
5. Bush PA, Aronson WJ, Buga GM, Rajfer J, Ignarro LJ (1992) Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol 147:1650
6. Dail WG, Barba V, Leyba L, Galindo R (1995) Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue. Cell Tissue Res 282:109
7. Fernandez E, Dail WG, Walton G, Martinez G (1991) The vasculature of the rat penis, a scanning electron microscopic and histoloaic study. Am J Anat 192:307
8. Förstermann U, Schmidt HHHW, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane MM, Murad F (1991) Isoforms of nitric oxide synthase: characterization and purification from different cell types. Biochem Pharmacol 42:1849
9. Grider JR (1993) Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol 264:G334
10. Hope BT, Michael GJ, Knigge KM, Vincent SR (1991) Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88:2811
11. Jünemann K, Ehmke H, Kummer W, Mayer B, Bührle C, Alken P (1993) Coexistence of nitric oxide synthase and vasoactive intestinal polypeptide in nerve terminals of human corpus cavernosum penis. J Urol 149:245A
12. Kim YC, Davies MG, Hagen PO, Carson CC (1994) Experimental evidence for endothelium dependent relaxation and neuronal nitric oxide in corpus cavernosum. Yonsei Med J 35:308
13. Kim YC, Kim JH, Davies MG, Hagen PO, Carson CC (1995) Modulation of vasoactive intestinal polypeptide (VIP)-mediated relaxation by nitric oxide and prostanoids in the rabbit corpus cavernosum. J Urol 153:807
14. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Sugarbaker D, Stamler JS (1993) Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9:371
15. Pollock JS, Nakane M, Förstermann U, Murad F (1993) Particulate and soluble bovine endothelial nitric oxide synthases are structurally similar proteins yet different from brain nitric oxide synthase. J Cardiovasc Pharmacol 20 [Suppl 12]:50
16. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ (1992) Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 326:90
17. Rand MJ (1992) Nitrergic transmission: nitric oxide as a mediator of non-adrenergic. non-cholinergic neuroeffector transmission. Clin Exp Pharmacol Physiol 19:147
18. Schmidt HHHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F (1993) Mapping of neural nitric oxide synthase in the rat suggests frequent colocalization with NADPH diaphorase. but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J Histochem Cytochem 40:1439
19. Tamura M, Kagawa S, Kimura K, Kawanishi Y, Tsuruo Y, Ishimura K (1995) Coexistence of nitric oxide synthase, tyrosine hydroxylase and vasoactive intestinal polypeptide in human penile tissue: a triple histochemical and immunohistochemical study. J Urol 153:530
20. Truss MC, Becker AJ, Djamihan MH, Stief CG, Jonas U (1994) Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction J Urol 44:553
21. Vernet D, Cai L, Garban H, Babbitt ML, Murray FT, Rajfer J, Gonzalez-Cadavid NF (1995) Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction. Endocrinology 136:5709