SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production

Journal of Immunology

Volumn 170, Issue 7, 2003, Pages 3653-3661

  Ishii, Tomonori ^b,d   Ohnuma, Kei ^a   Murakami, Akikazu ^b   Takasawa, Naruhiko ^b   Yamochi, Tadanori ^c   Iwata, Satoshi ^a   Uchiyama, Masahiko ^a   Dang, Nam H ^c   Tanaka, Hirotoshi ^a   Morimoto, Chikao ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD28 ANTIGEN; INTERLEUKIN 2; PROTEIN; RO52 PROTEIN; SS A ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

EID: 0346665753     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.7.3653     Document Type: Article

References (35)

1. Ben-Chetrit, E., E. K. Chan, K. F. Sullivan, and E. M. Tan. 1988. A 52-kD protein is a novel component of the SS-A/Ro antigenic particle. J. Exp. Med. 167:1560.
2. Harley, J. B., E. L. Alexande, W. B. Bias, O. F. Fox, T. T. Provost, M. Reichlin, H. Yamagata, and F. C. Amett. 1986. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjogren's syndrome. Arthritis Rheum. 29:196.
3. Provost, T. T., R. Watson, W. R. Gammon, M. Radowsky, J. B. Harley, and M. Reichlin. 1997. The neonatal lupus syndrome associated with U1RNP (nRNP) antibodies. N. Engl. J. Med. 30:1135.
4. Lee, L. A., C. M. Roberts, M. B. Frank, V. R. McCubbin, and M. Reichlin. 1994. The autoantibody response to Ro/SSA in cutaneous lupus erythematosus. Arch. Dennatol. 130:1262.
5. Rudd, C. E. 1996. Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity 4:527.
6. Sharpe, A. H., and J. G. Freeman. 2002. The B7-CD28 superfamily. Nat. Rev. Immun. 2:116.
7. Sharpe, A. H. 1995. Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice. Curr. Opin. Immunol. 7:389.
8. Salmon, B., and J. A. Bluestone. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19:225.
9. Kane, L. P., and A. Weiss. 2002. It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends Immunol. 23:413.
10. Frauwirth, K. A., and C. B. Thompson. 2002. Activation & inhibition of lymphocytes by costimulation. J. Clin. Invest. 109:295.
11. Kung, P., G. Goldstein, E. L. Reinherz, and S. F. Schlossman. 1979. Monoclonal antibodies defining distinctive human T cell surface antigens. Science 206:347.
12. Gimmi, C. D., G. J. Freeman, K. Sugita, A. S. Freedman, C. Morimoto, and L. N. Nadler. 1991. B-cell surface antigen B7 provides a costimulatory signal which induces T cells to proliferate and secrete IL-2. Proc. Natl. Acad. Sci. USA 88:6575.
13. Elbashir, S. M., W. Lendeckel, and T. Tuschl. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:188.
14. Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, C. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494.
15. Elbashir, S. M., J. Martinez, A. Patkaniowska, W. Lendeckel, and T. Tuschl. 2001. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 3:6877.
16. Himes, S. R., R. Reeves, J. Attema, M. Nissen, Y. Li, and M. F. Shannon. 2000. The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation. J. Immunol. 164:3157.
17. Lenschow, D. J., S. C. Ho, H. Satter, L. Rhee, G. Gray, N. Nabavi, K. C. Herold, and J. A. Bluestome. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the non-obese diabetic mouse. J. Exp. Med. 181:1145.
18. Cross, A. H., T. J. Girard, K. S. Giacoletto, R. J. Evans, R. M. Keeling, R. F. Lin, J. L. Trotter, and R. W. Karr. 1995. Long-term inhibition of murine experimental autoimmune encephalomyelitis: using CTLA4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95:2783.
19. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable threshold. Science 273:104.
20. Weiss, A., B. Manger, and J. Imboden. 1986. Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J. Immunol. 137:819.
21. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
22. Zhou, X. Y., Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara. 2002. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. J. Immunol. 168:3847.
23. Alspaugh, M. A., and E. M. Tan. 1975. Antibodies to cellular antigens in Sjogren's syndrome. J. Clin. Invest. 55:1067.
24. Rader, M. D., C. O'Brien, Y. S. Liu, J. B. Harley, and M. Reichlin. 1989. Heterogeneity of the Ro/SSA antigen: different molecular forms in lymphocytes and red blood cells. J. Clin. Invest. 83:1293.
25. Deutscher, S. L., J. B. Harley, and J. D. Keene. 1988. Molecular analysis of the 60-kDa human Ro ribonucleoprotein. Proc. Natl. Acad. Sci. USA 85:9479.
26. Chan, E. K. L., F. D. Di Donato, J. C. Hamel, C. E. Tseng, and J. P. Buyon. 1995. 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. J. Exp. Med. 182:983.
27. Chan, E. K., J. C. Hamel, J. P. Buyon, and E. M. Tan. 1991. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J. Clin. Invest. 87:68.
28. O'Brien, C. A., and S. L. Wolin. 1994. A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. Genes Dev. 8:2891.
29. Buyon, J. P., C. E. Tseng, F. Di Donato, W. Rashbaum, A. Morris, and E. K. L. Chan. 1997. Cardiac expression of 52-β, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development. Arthritis Rheum. 40:655.
30. Wang, D., J. P. Buyon, Z. Yang, F. Di Donato, M. E. Miranda-Carus, and E. K. L. Chan. 2001. Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity. Biochim. Biophys. Acta 1568:155.
31. Frank, M. B. 1999. Characterization of DNA binding properties and sequence specificity of the human 52 kDa Ro/SS-A (Ro52) zinc finger protein. Biochim. Biophys. Acta 259:665.
32. Schmitz, M., M. Bachmann, J. Laubinger, J. P. Thijssen, and G. J. Pruijn. 1997. Characterization of murine monoclonal antibodies against the Ro52 autoantigen. Clin. Exp. Immunol. 110:53.
33. Reymond, A., G. Meroni, A. Fantozzi, G. Meria, S. Cairo, L. Luzi, D. Riganelli, E. Zanaria, S. Messali, S. Cainarca, et al. 2001. The tripartite motif family identifies cell compartments. EMBO J. 20:2140.
34. Patarca, R., J. G. Freeman, J. Schwartz, R. P. Singh, Q. T. Kong, E. Murphy, Y. Anderson, F. Y. Sheng, P. Singh, and K. A. Johnson. 1988. rpt. 1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 85:2733.
35. Harboth, J., S. M. Elbashir, K. Bechert, T. Tuschl, and K. Weber. 2001. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 114:4557.