Spiroimidazolidinone library derivatives on synphase lanterns

Journal of Combinatorial Chemistry

Volumn 5, Issue 4, 2003, Pages 356-361

  Feliu, Lidia ^a   Subra, Gilles ^a   Martinez, Jean ^a   Amblard, Muriel ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOLE DERIVATIVE; PIPERIDONE DERIVATIVE;

ARTICLE; COMBINATORIAL CHEMISTRY; DRUG SYNTHESIS; SOLID;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IMIDAZOLES; SPIRO COMPOUNDS;

EID: 0141452158     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc020111p     Document Type: Article

References (15)

1. Bunin, B. A.; Ellman, J. A. J. Am. Chem. Soc. 1992, 114, 10997-10998.
2. Patchett, A. A.; Nargund, R. P.; Tata, J. R.; Chen, M. H.; Barakat, K. J.; Johnston, D. B.; Cheng, K.; Chan, W. W.; Butler, B.; Hickey, G. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (15), 7001-7005.
3. Mason, J. S.; Morize, I.; Menard, P. R.; Cheney, D. L.; Hulme, C.; Labaudiniere, R. F. J. Med. Chem. 1999, 429, 3251-3264.
4. Patchett, A. A.; Nargund, R. P. Annu. Rep. Med. Chem. 2000, 35, 289-298.
5. (a) Mavunkel, B. J.; Lu, Z.; Goehring, R. R.; Lu, S.; Chakravarty, S.; Perumattam, J.; Novotny, E. A.; Connolly, M.; Valentine, H.; Kyle, D. J. J. Med. Chem. 1996, 39, 3169-3173.
6. (b) Bedos, P.; Amblard, M.; Subra, G.; Dodey, P.; Luccarini, J. M.; Paquet, J. L.; Pruneau, D.; Aumelas, A.; Martinez, J. J. Med. Chem. 2000, 43, 2387-2394.
7. Bleicher, K. H.; Wüthrich, Y.; De Boni, M.; Kolczewski, S.; Hoffmann, T.; Sleight, A. J. Bioorg. Med. Chem. Lett. 2002, 12, 2519-2522.
8. Zehavi, U.; Ben-Ishai, D. J. Org. Chem. 1961, 26, 1097-1101.
9. (a) Ishihara, Y.; Yukimasa, H.; Miyamoto, M.; Goto, G. Chem. Pharm. Bull. 1992, 40, 1177-1185.
10. (b) Khalaj, A.; Bazaz, R. D.; Shekarchi, M. Monatsh. Chem. 1997, 128, 395-398.
11. Bray, A. M.; Chiefari, D. S.; Valerio, R. M.; Maeji, N. J. Tetrahedron Lett. 1995, 36, 5081-5084.
12. Smith, J. M.; Gard, J.; Cummings, W.; Kanizsai, A.; Krchnak, V. J. Comb. Chem. 1999, 1, 368-370.
13. For common members of chemsets 2 and 2′, we used two different colored spindles in order to differentiate Rink and trityl lanterns.
14. Only eight different colored cogs were available; we then used one or two cogs to tag all the members of chemsets 6 and 6′.
15. The stability of the spirocyclic compounds in these acidic conditions was checked. After 15 days, 15% of hydrolyzed compound was observed. Compounds may be stocked as a powder, which was totally stable.