A double-headed pro-drug that overcomes chloroquine resistance

Trends in Parasitology

Volumn 18, Issue 3, 2002, Pages 103-

  Ginsburg, Hagai ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE; ANTIMALARIAL AGENT; CHLOROQUINE; GLUTATHIONE REDUCTASE; N [3 [(7 CHLORO 4 QUINOLYL)AMINO] 5 (HYDROXYMETHYL)PHENYL] 2 PIPERIDINOACETAMIDE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IC 50; MALARIA; MOUSE; NONHUMAN; NOTE; PLASMODIUM FALCIPARUM; TREATMENT OUTCOME;

ANIMALIA; PLASMODIUM FALCIPARUM;

EID: 0036498425     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1471-4922(02)02260-2     Document Type: Note

References (2)

1. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline
2. Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines