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Volumn 533, Issue , 2003, Pages 205-211

A2E, a fluorophore of RPE lipofuscin: Can it cause RPE degeneration?

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN; RETINAL; RETINOID;

EID: 0346271772     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0067-4_26     Document Type: Conference Paper
Times cited : (39)

References (56)
  • 1
    • 0034617212 scopus 로고    scopus 로고
    • The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy
    • Ahn J, Wong JT, Molday RS, 2000, The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy. J Biol Chem. 275:20399.
    • (2000) J Biol Chem , vol.275 , pp. 20399
    • Ahn, J.1    Wong, J.T.2    Molday, R.S.3
  • 2
    • 0033859128 scopus 로고    scopus 로고
    • Further evidence for an association of ABCR alleles with age-related macular degeneration
    • The international ABCR Screening Consortium
    • Allikmets R, 2000, Further evidence for an association of ABCR alleles with age-related macular degeneration. The international ABCR Screening Consortium. Am J Hum Genet. 67:487.
    • (2000) Am J Hum Genet , vol.67 , pp. 487
    • Allikmets, R.1
  • 4
    • 0036495230 scopus 로고    scopus 로고
    • Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement
    • Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K, 2002a, Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed. 41:814.
    • (2002) Angew Chem Int Ed , vol.41 , pp. 814
    • Ben-Shabat, S.1    Itagaki, Y.2    Jockusch, S.3    Sparrow, J.R.4    Turro, N.J.5    Nakanishi, K.6
  • 6
    • 0343083350 scopus 로고    scopus 로고
    • Age-related macular degeneration: Drusen and geographic atrophy
    • Albert DM, Jakobiec FA, Azar DT, Gragoudas ES (eds). W.B. Saunders Co, Philadelphia
    • Bressler SB, Bressler NM, Gragoudas ES, 2000, Age-related macular degeneration: drusen and geographic atrophy. In: Albert DM, Jakobiec FA, Azar DT, Gragoudas ES (eds) Principles and Practice of Ophthalmology, vol 3. W.B. Saunders Co, Philadelphia, pp 1982.
    • (2000) Principles and Practice of Ophthalmology , vol.3 , pp. 1982
    • Bressler, S.B.1    Bressler, N.M.2    Gragoudas, E.S.3
  • 7
    • 0033190649 scopus 로고    scopus 로고
    • The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina
    • Busch EM, Gorgels TGMF, Roberts JE, van Norren D, 1999a, The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina. Photochem Photobiol. 70:353.
    • (1999) Photochem Photobiol , vol.70 , pp. 353
    • Busch, E.M.1    Gorgels, T.G.M.F.2    Roberts, J.E.3    Van Norren, D.4
  • 8
    • 0032964280 scopus 로고    scopus 로고
    • Temporal sequences of changes in rat retina after UV-A and blue light exposure
    • Busch EM, Gorgels TGMF, van Norren D, 1999b, Temporal sequences of changes in rat retina after UV-A and blue light exposure. Vision Res. 39:1233.
    • (1999) Vision Res , vol.39 , pp. 1233
    • Busch, E.M.1    Tgmf, G.2    Van Norren, D.3
  • 9
    • 0036023396 scopus 로고    scopus 로고
    • Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration
    • De S, Sakmar TP, 2002, Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration. J Gen Physiol. 120:147.
    • (2002) J Gen Physiol , vol.120 , pp. 147
    • De, S.1    Sakmar, T.P.2
  • 10
    • 0004368243 scopus 로고
    • RPE lipofuscin in ageing and age-related macular degeneration
    • Coscas G, Piccolino FC (eds). Kluwer Academic Publishers, Dordrecht, The Netherlands
    • Delori FC, 1995, RPE lipofuscin in ageing and age-related macular degeneration. In: Coscas G, Piccolino FC (eds) Retinal Pigment Epithelium and Macular Disease (Documenta Ophthalmologica), vol 62. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp 37.
    • (1995) Retinal Pigment Epithelium and Macular Disease (Documenta Ophthalmologica) , vol.62 , pp. 37
    • Delori, F.C.1
  • 12
    • 0034940622 scopus 로고    scopus 로고
    • Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects
    • Delori FC, Goger DG, Dorey CK, 2001, Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 42:1855.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1855
    • Delori, F.C.1    Goger, D.G.2    Dorey, C.K.3
  • 14
    • 0024378477 scopus 로고
    • Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration
    • Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ, 1989, Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 30:1691.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 1691
    • Dorey, C.K.1    Wu, G.2    Ebenstein, D.3    Garsd, A.4    Weiter, J.J.5
  • 15
    • 0002514830 scopus 로고    scopus 로고
    • Lipofuscin and other lysosomal storage deposits in the retinal pigment epithelium
    • Marmor MF, Wolfensberger TJ (eds). Oxford University Press, New York
    • Eldred GE, 1998, Lipofuscin and other lysosomal storage deposits in the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ (eds) The Retinal Pigment Epithelium: Function and Disease. Oxford University Press, New York, pp 651.
    • (1998) The Retinal Pigment Epithelium: Function and Disease , vol.651
    • Eldred, G.E.1
  • 16
    • 0023814969 scopus 로고
    • Fluorophores of the human retinal pigment epithelium: Separation and spectral characterization
    • Eldred GE, Katz ML, 1988, Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp Eye Res. 47:71.
    • (1988) Exp Eye Res , vol.47 , pp. 71
    • Eldred, G.E.1    Katz, M.L.2
  • 17
    • 0027410970 scopus 로고
    • Retinal age pigments generated by self-assembling lysosomotropic detergents
    • Eldred GE, Lasky MR, 1993, Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature 361:724.
    • (1993) Nature , vol.361 , pp. 724
    • Eldred, G.E.1    Lasky, M.R.2
  • 18
    • 0021323978 scopus 로고
    • Aging human RPE: Morphometric analysis of macular, equatorial, and peripheral cells
    • Feeney-Burns L, Hilderbrand ES, Eldridge S, 1984, Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 25:195.
    • (1984) Invest Ophthalmol Vis Sci , vol.25 , pp. 195
    • Feeney-Burns, L.1    Hilderbrand, E.S.2    Eldridge, S.3
  • 23
    • 0035069027 scopus 로고    scopus 로고
    • Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    • Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE, 2001, Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 42:1051.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1051
    • Holz, F.G.1    Bellman, C.2    Staudt, S.3    Schutt, F.4    Volcker, H.E.5
  • 24
    • 0033026846 scopus 로고    scopus 로고
    • Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration
    • Holz FG, Bellmann C, Margaritidis M, Schutt F, Otto TP, Volcker HE, 1999, Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol. 237:145.
    • (1999) Graefe's Arch Clin Exp Ophthalmol , vol.237 , pp. 145
    • Holz, F.G.1    Bellmann, C.2    Margaritidis, M.3    Schutt, F.4    Otto, T.P.5    Volcker, H.E.6
  • 25
    • 0022909003 scopus 로고
    • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium
    • Katz ML, Drea CM, Robison WG, Jr., 1986, Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. Mech Ageing Dev. 35:291.
    • (1986) Mech Ageing Dev , vol.35 , pp. 291
    • Katz, M.L.1    Drea, C.M.2    Robison Jr., W.G.3
  • 26
    • 0026627787 scopus 로고
    • Reduced phagosomal content of the retinal pigment epithelium in response to retinoid deprivatioin
    • Katz ML, Norberg M, Stientjes HJ, 1992, Reduced phagosomal content of the retinal pigment epithelium in response to retinoid deprivatioin. Invest Ophthalmol Vis Sci. 33:2612.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 2612
    • Katz, M.L.1    Norberg, M.2    Stientjes, H.J.3
  • 27
    • 0034754212 scopus 로고    scopus 로고
    • Effect of Rpe65 knockouton accumulation of lipofuscin fluorophores in the retinal pigment epithelium
    • Katz ML, Redmond TM, 2001, Effect of Rpe65 knockouton accumulation of lipofuscin fluorophores in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 42:3023.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 3023
    • Katz, M.L.1    Redmond, T.M.2
  • 28
    • 0029562829 scopus 로고
    • Lipofuscin of the retinal pigment epithelium: A review
    • Kennedy CJ, Rakoczy PE, Constable IJ, 1995, Lipofuscin of the retinal pigment epithelium: a review. Eye 9:763.
    • (1995) Eye , vol.9 , pp. 763
    • Kennedy, C.J.1    Rakoczy, P.E.2    Constable, I.J.3
  • 29
    • 0024419048 scopus 로고
    • In vivo quantitation of autofluorescence in human retinal pigment epithelium
    • Kitagawa K, Nishida S, Ogura Y, 1989, In vivo quantitation of autofluorescence in human retinal pigment epithelium. Ophthalmologica 199:116.
    • (1989) Ophthalmologica , vol.199 , pp. 116
    • Kitagawa, K.1    Nishida, S.2    Ogura, Y.3
  • 30
    • 0024413809 scopus 로고
    • The association of age-related macular degeneration and lens opacities in the aged
    • Liu IY, White L, LaCroix AZ, 1989, The association of age-related macular degeneration and lens opacities in the aged. Am J Public Health 79:765.
    • (1989) Am J Public Health , vol.79 , pp. 765
    • Liu, I.Y.1    White, L.2    LaCroix, A.Z.3
  • 31
    • 0034703010 scopus 로고    scopus 로고
    • The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane
    • Liu J, Itagaki Y, Ben-Shabat S, Nakanishi K, Sparrow JR, 2000, The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane. J Biol Chem. 275:29354.
    • (2000) J Biol Chem , vol.275 , pp. 29354
    • Liu, J.1    Itagaki, Y.2    Ben-Shabat, S.3    Nakanishi, K.4    Sparrow, J.R.5
  • 32
    • 0025363287 scopus 로고
    • Autosomal-dominant fundus favimaculatus. Clinicopathologic correlation
    • Lopez PF, Maumenee IH, de la Cruz Z, Green WR, 1990, Autosomal-dominant fundus favimaculatus. Clinicopathologic correlation. Ophthalmol. 97 798.
    • (1990) Ophthalmol , vol.97 , pp. 798
    • Lopez, P.F.1    Maumenee, I.H.2    De La Cruz, Z.3    Green, W.R.4
  • 33
    • 0034944895 scopus 로고    scopus 로고
    • Delayed dark adaptation and lipofuscin accumulation in abcr+/- Mice: Implications for involvement of ABCR in age-related macular degeneration
    • Mata NL, Tzekov RT, Liu X, Weng J, Birch DG, Travis GH, 2001, Delayed dark adaptation and lipofuscin accumulation in abcr+/-mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci. 42:1685.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1685
    • Mata, N.L.1    Tzekov, R.T.2    Liu, X.3    Weng, J.4    Birch, D.G.5    Travis, G.H.6
  • 34
    • 0034691089 scopus 로고    scopus 로고
    • Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration
    • Mata NL, Weng J, Travis GH, 2000, Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci U S A. 97:7154.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7154
    • Mata, N.L.1    Weng, J.2    Travis, G.H.3
  • 36
    • 0032438193 scopus 로고    scopus 로고
    • Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium
    • Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow JR, 1998, Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci U S A. 95:14609.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14609
    • Parish, C.A.1    Hashimoto, M.2    Nakanishi, K.3    Dillon, J.4    Sparrow, J.R.5
  • 37
    • 0031954443 scopus 로고    scopus 로고
    • The course of age-related macular degeneration following bilateral cataract surgery
    • Pollack A, Bukelman A, Zalish M, Leiba H, Oliver M, 1998, The course of age-related macular degeneration following bilateral cataract surgery. Ophthalmic Surg Lasers 29:286.
    • (1998) Ophthalmic Surg Lasers , vol.29 , pp. 286
    • Pollack, A.1    Bukelman, A.2    Zalish, M.3    Leiba, H.4    Oliver, M.5
  • 38
    • 0029966177 scopus 로고    scopus 로고
    • Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation
    • Pollack A, Marcovich A, Bukelman A, Oliver M, 1996, Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation. Ophthalmology 103:1546.
    • (1996) Ophthalmology , vol.103 , pp. 1546
    • Pollack, A.1    Marcovich, A.2    Bukelman, A.3    Oliver, M.4
  • 39
    • 0028273215 scopus 로고
    • Blue-light-induced dysfunction of the blood-retinal barrier at the pigment epithelium in albino versus pigmented rabbits
    • Putting BJ, Van Best JA, Vrensen GFJM, Oosterhuis JA, 1994, Blue-light-induced dysfunction of the blood-retinal barrier at the pigment epithelium in albino versus pigmented rabbits. Exp Eye Res 58:31.
    • (1994) Exp Eye Res , vol.58 , pp. 31
    • Putting, B.J.1    Van Best, J.A.2    Vrensen, G.F.J.M.3    Oosterhuis, J.A.4
  • 40
    • 0023037646 scopus 로고
    • Cone-rod dystrophy. A clinical and histopathologic report
    • Rabb MF, Tso MO, Fishman GA, 1986, Cone-rod dystrophy. A clinical and histopathologic report. Ophthalmology 93:1443.
    • (1986) Ophthalmology , vol.93 , pp. 1443
    • Rabb, M.F.1    Tso, M.O.2    Fishman, G.A.3
  • 41
    • 0030980348 scopus 로고    scopus 로고
    • Total synthesis of the ocular age pigment A2E: A convergent pathway
    • Ren RP, Sakai N, Nakanishi K, 1997, Total synthesis of the ocular age pigment A2E: a convergent pathway. J. Am. Chem. Soc. 119:3619.
    • (1997) J Am Chem Soc , vol.119 , pp. 3619
    • Ren, R.P.1    Sakai, N.2    Nakanishi, K.3
  • 42
    • 0029985705 scopus 로고    scopus 로고
    • Ocular age pigment "A2E": An unprecedented pyridinium bisretinoid
    • Sakai N, Decatur J, Nakanishi K, Eldred GE, 1996, Ocular age pigment "A2E": An unprecedented pyridinium bisretinoid. J. Am. Chem. Soc. 118:1559.
    • (1996) J Am Chem Soc , vol.118 , pp. 1559
    • Sakai, N.1    Decatur, J.2    Nakanishi, K.3    Eldred, G.E.4
  • 44
    • 0035040640 scopus 로고    scopus 로고
    • Blue light-induced apoptosis of A2E-containing RPE: Involvement of caspase-3 and protection by Bcl-2
    • Sparrow JR, Cai B, 2001, Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. Invest Ophthalmol Vis Sci 42:1356.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1356
    • Sparrow, J.R.1    Cai, B.2
  • 45
    • 0034086115 scopus 로고    scopus 로고
    • The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells
    • Sparrow JR, Nakanishi K, Parish CA, 2000, The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41:1981.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1981
    • Sparrow, J.R.1    Nakanishi, K.2    Parish, C.A.3
  • 46
  • 48
    • 0037408428 scopus 로고    scopus 로고
    • DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue light illumination
    • in press
    • Sparrow Jr, Zhou J, Cai B, 2003, DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue light illumination. IOVS (in press)
    • (2003) IOVS
    • Sparrow, Jr.1    Zhou, J.2    Cai, B.3
  • 49
    • 0000761427 scopus 로고    scopus 로고
    • Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease
    • Sun H, Molday RS, Nathans J, 1999, Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. J Biol Chem. 274:8269.
    • (1999) J Biol Chem , vol.274 , pp. 8269
    • Sun, H.1    Molday, R.S.2    Nathans, J.3
  • 51
    • 0344830731 scopus 로고    scopus 로고
    • Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope
    • von Rückmann A, Fitzke FW, Bird AC, 1997, Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 38:478.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 478
    • Von Rückmann, A.1    Fitzke, F.W.2    Bird, A.C.3
  • 53
    • 0022585542 scopus 로고
    • Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes
    • Weiter JJ, Delori FC, Wing GL, Fitch KA, 1986, Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 27:145.
    • (1986) Invest Ophthalmol Vis Sci , vol.27 , pp. 145
    • Weiter, J.J.1    Delori, F.C.2    Wing, G.L.3    Fitch, K.A.4
  • 54
    • 0033538438 scopus 로고    scopus 로고
    • Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
    • Weng J, Mata NL, Azarian SM, Tzekov RT, Birch DG, Travis GH, 1999, Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98:13.
    • (1999) Cell , vol.98 , pp. 13
    • Weng, J.1    Mata, N.L.2    Azarian, S.M.3    Tzekov, R.T.4    Birch, D.G.5    Travis, G.H.6
  • 56
    • 0017897377 scopus 로고
    • The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium
    • Wing GL, Blanchard GC, Weiter JJ, 1978, The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 17:601.
    • (1978) Invest Ophthalmol Vis Sci , vol.17 , pp. 601
    • Wing, G.L.1    Blanchard, G.C.2    Weiter, J.J.3


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