Genomic Absence of the Gene Encoding T Cell Receptor V β7.2 Is Linked to the Presence of Autoantibodies in Sjögren's Syndrome

Arthritis and Rheumatism

Volumn 50, Issue 1, 2004, Pages 187-198

  Manavalan, Sanil J ^a   Valiando, Jennifer R ^a   Reeves, Westley H ^b   Arnett, Frank C ^c   Necker, Antje ^d   Simantov, Ronit ^a   Lyons, Robert ^b   Satoh, Minoru ^b   Posnett, David N ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Immunotech   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GENE PRODUCT; HLA ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR VBETA 7.2; UNCLASSIFIED DRUG;

ALLELE; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE DELETION; GENE INSERTION; GENETIC CODE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE RECEPTOR GENE;

ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; FEMALE; GENOTYPE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PEDIGREE; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME; T-LYMPHOCYTES;

EID: 0345827488     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11429     Document Type: Article

References (73)

1. Ortman RA, Holderbaum D, Qu XM, Banerjee S, Haqqi TM. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 1994;152:4175-82.
2. Nabozny GH, Bull MJ, Hanson J, Griffiths MM, Luthra HS, David CS. Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice. J Exp Med 1994;180:517-24.
3. Osman GE, Hannibal MC, Anderson JP, Lasky SR, Ladiges WC, Hood L. FVB/N (H2(q)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments. Immunogenetics 1999;49:851-9.
4. Noonan DJ, McConahey PJ, Cardenas GJ. Correlations of autoimmunity with H-2 and T cell receptor beta chain genotypes in (NZB × NZW) F2 mice. Eur J Immunol 1990;20:1105-10.
5. Fox RI. Sjögren's syndrome. In: Kelley WN, Harris ED, Ruddy S, Sledge CG, editors. Textbook of rheumatology. Philadelphia: Saunders; 1997. p. 955.
6. Chan EK, Andrade LE. Antinuclear antibodies in Sjögren's syndrome. Rheum Dis Clin North Am 1992;18:551-70.
7. Zhao TM, Whitaker SE, Robinson MA. A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments. J Exp Med 1994;180:1405-14.
8. Kay RA, Hutchings CJ, Ollier WE. A subset of Sjögren's syndrome associates with the TCRBV13S2 locus but not the TCRBV2S1 locus. Hum Immunol 1995;42:328-30.
9. Arden B, Clark SP, Kabelitz D, Mak TW. Human T-cell receptor variable gene segment families. Immunogenetics 1995;42:455-500.
10. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
11. Li Y, Szabo P, Robinson MA, Dong B, Posnett DN. Allelic variations in the human T cell receptor Vβ6.7 gene products. J Exp Med 1990;171:221-30.
12. Posnett DN, Wang CY, Friedman S. Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. Proc Natl Acad Sci U S A 1986;83:7888-92.
13. Reveille JD, Macleod MJ, Whittington K, Arnett FC. Specific amino acid residues in the second hypervariable region of HLA-DQA1 and DQB1 chain genes promote the Ro (SS-A)/La (SS-B) autoantibody responses. J Immunol 1991;146:3871-6.
14. Travaglio-Encinoza A, Chaouni I, DerSimonian H, Jorgensen C, Simony-Lafontaine J, Romagne F, et al. T cell receptor distribution in rheumatoid synovial follicles. J Rheumatol 1995;22:394-9.
15. Posnett DN, Romagne F, Necker A, Kotzin BL, Sekaly R-P. Summary: first human TCR monoclonal antibody workshop. Immunologist 1996;4:5-8.
16. Satoh M, Langdon JJ, Hamilton KJ, Richards HB, Panka D, Eisenberg RA, et al. Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein. J Clin Invest 1996;97:2619-26.
17. Reeves WH, Satoh M, McCauliffe DP. Autoantibody testing by non-FITC methods. In: Rose NR, Hamilton RG, Detrick B, editors. Manual of clinical laboratory immunology. Washington, DC: American Society of Microbiology Press; 2002. p. 933.
18. Wang J, Satoh M, Kabir F, Shaw M, Domingo MA, Mansoor R, et al. Increased prevalence of autoantibodies to ku antigen in African American versus white patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2367-70.
19. Schneider C, Newman RA, Sutherland DR, Asser U, Greaves MF. A one-step purification of membrane proteins using a high efficiency immunomatrix. J Biol Chem 1982;257:10766-9.
20. Bradwell AR. Immunofluorescent antinuclear antibody tests. In: Rose NR, Hamilton RG, Detrick B, editors. Manual of clinical laboratory immunology. Washington, DC: American Society of Microbiology Press; 2002. p. 922.
21. Satoh M, Kumar A, Kanwar YS, Reeves WH. Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane. Proc Natl Acad Sci U S A 1995;92:10934-8.
22. Satoh M, Weintraub JP, Yoshida H, Shaheen VM, Richards HB, Shaw M, et al. Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus. J Immunol 2000;165:1036-43.
23. Seboun E, Houghton L, Hatem CJ Jr, Lincoln R, Hauser SL. Unusual organization of the human T-cell receptor β-chain gene complex is linked to recombination hotspots. Proc Natl Acad Sci U S A 1993;90:5026-9.
24. Liao L, Marinescu A, Molano A, Ciurli C, Sekaly R-P, Fraser JD, et al. TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9). J Exp Med 1996;184:1471-82.
25. Choi Y, Kotzin B, Lafferty J, White J, Pigeon M, Kubo R, et al. A method for production of antibodies to human T-cell receptor β-chain variable regions. Proc Natl Acad Sci U S A 1991;88:8357-61.
26. Akolkar PN, Gulwani-Akolkar B, Robinson MA, Silver J. The influence of non-HLA genes on the human T-cell receptor repertoire. Scand J Immunol 1995;42:248-56.
27. Posnett DN, Vissinga CS, Pambuccian C, Wei S, Robinson MA, Kostyu D, et al. Level of human TCRBV3S1 (Vβ3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence. J Exp Med 1994;179:1707-11.
28. Harley JB, Reichlin M, Arnett FC, Alexander EL, Bias WB, Provost TT. Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren's syndrome. Science 1986;232:1145-7.
29. Hayashi Y, Haneji N, Hamano H, Yanagi K. Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 1994;24:2826-31.
30. Namekawa T, Kuroda K, Kato T, Yamamoto K, Murata H, Sakamaki T, et al. Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol 1995;22:2092-9.
31. Sumida T, Namekawa T, Maeda T, Nishioka K. New T-cell epitope of Ro/SS-A 52 kDa protein in labial salivary glands from patients with Sjögren's syndrome [letter]. Lancet 1996;348:1667.
32. Halse AK, Wahren M, Jonsson R. Peripheral blood in Sjögren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-B 48 kD autoantigens. Autoimmunity 1996;23:25-34.
33. Reynolds P, Gordon TP, Purcell AW, Jackson DC, McCluskey J. Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice. J Exp Med 1996;184:1857-70.
34. Farris AD, Brown L, Reynolds P, Harley JB, James JA, Scofield RH, et al. Induction of autoimmunity by multivalent immunodominant and subdominant T cell determinants of La (SS-B). J Immunol 1999;162:3079-87.
35. Reveille JD, Arnett FC. The immunogenetics of Sjögren's syndrome. Rheum Dis Clin North Am 2000;18:539-50.
36. Rischmueller M, Lester S, Chen Z, Champion G, Van Den Berg R, Beer R, et al. HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS). Clin Exp Immunol 1998;111:365-71.
37. Deshmukh US, Lewis JE, Gaskin F, Kannapell CC, Waters ST, Lou YH, et al. Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies. J Exp Med 1999;189:531-40.
38. McCluskey J, Farris AD, Keech CL, Purcell AW, Rischmueller M, Kinoshita G, et al. Determinant spreading: lessons from animal models and human disease. Immunol Rev 1998;164:209-29.
39. Scofield RH, Farris AD, Horsfall AC, Harley JB. Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins. Arthritis Rheum 1999;42:199-209.
40. Scofield RH, Kaufman KM, Baber U, James JA, Harley JB, Kurien BT. Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse. Arthritis Rheum 1999;42:1017-24.
41. Scofield RH, Henry WE, Kurien BT, James JA, Harley JB. Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity. J Immunol 1996;156:4059-66.
42. Moudgil KD. Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic. Immunol Rev 1998;164:175-84.
43. McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med 1995;182:75-85.
44. Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat Rev Immunol 2002;2:85-95.
45. McFarland HI, Lobito AA, Johnson MM, Nyswaner JT, Frank JA, Palardy GR, et al. Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol 1999;162:2384-90.
46. Yu M, Johnson JM, Tuohy VK. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J Exp Med 1996;183:1777-88.
47. Routsias JG, Touloupi E, Dotsika E, Moulia A, Tsikaris V, Sakarellos C, et al. Unmasking the anti-La/SSB response in sera from patients with Sjögren's syndrome by specific blocking of anti-idiotypic antibodies to La/SSB antigenic determinants. Mol Med 2002;8:293-305.
48. Sumida T, Yonaha F, Maeda T, Tanabe E, Koike T, Tomioka H, et al. T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients. J Clin Invest 1992;89:681-5. Erratum in: J Clin Invest 1992;90:293.
49. Sumida T, Yonaha F, Maeda T, Tanabe E, Koike T, Tomioka H, et al. T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients. J Clin Invest 1992;89:681-5. Erratum in: J Clin Invest 1992;90:293.
50. Pivetta B, De Vita S, Ferraccioli G, De Re V, Gloghini A, Marzotto A, et al. T cell receptor repertoire in B cell lymphoproliferative lesions in primary Sjögren's syndrome. J Rheumatol 1999;26:1101-9.
51. Yonaha F, Sumida T, Maeda T, Tomioka H, Koike T, Yoshida S. Restricted junctional usage of T cell receptor Vβ2 and Vβ13 genes, which are overrepresented on infiltrating T cells in the lips of patients with Sjögren's syndrome. Arthritis Rheum 1992;35:1362-7.
52. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:1376-84.
53. Karim SN, Murphy EA, Sturrock RD, Goudie RB. T-cell clonality in synovial fluid from rheumatoid joints before and after culture in interleukin-2. Br J Rheumatol 1995;34:232-5.
54. Dwyer E, Itescu S, Winchester R. Characterization of the primary structure of T cell receptor β-chains infiltrating the salivary gland in the sicca syndrome of HIV-1 infection: evidence of antigen-driven clonal selection suggested by restricted combinations of Vβ and Jβ gene segment usage and shared somatically encoded amino acid residues. J Clin Invest 1993;92:495-502.
55. Legras F, Martin T, Knapp AM, Pasquali JL. Infiltrating T cells from patients with primary Sjögren's syndrome express restricted or unrestricted T cell receptor V beta regions depending on the stage of the disease. Eur J Immunol 1994;24:181-5.
56. Sumida T, Matsumoto I, Maeda T, Nishioka K. T-cell receptor in Sjögren's syndrome. Br J Rheumatol 1997;36:622-9.
57. Kumar V, Stellrecht K, Sercarz E. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J Exp Med 1996;184:1609-17.
58. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000;18:423-49.
59. Kumar V, Sercarz E. Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells. J Immunol 1998;161:6585-91.
60. Saegusa K, Ishimaru N, Yanagi K, Haneji N, Nishino M, Azuma M, et al. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndrome. J Immunol 2000;165:2251-7.
61. Lawson BR, Prud'homme GJ, Chang Y, Gardner HA, Kuan J, Kono DH, et al. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J Clin Invest 2000;106:207-15.
62. Reininger L, Santiago ML, Takahashi S, Fossati L, Izui S. T helper cell subsets in the pathogenesis of systemic lupus erythematosus. Ann Med Interne (Paris) 1996;147:467-71.
63. Peng SL, Moslehi J, Craft J. Roles of interferon-γ and interleukin-4 in murine lupus. J Clin Invest 1997;99:1936-46.
64. Kirou KA, Crow MK. New pieces to the SLE cytokine puzzle. Clin Immunol 1999;91:1-5.
65. Robinson MA, Kindt TJ. Segregation of polymorphic T-cell receptor genes in human families. Proc Natl Acad Sci U S A 1985;82:3804-8.
66. Seboun E, Robinson MA, Doolittle TH, Ciulla TA, Kindt TJ, Hauser SL. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell 1989;57:1095-100.
67. Wei S, Charmley P, Birchfield RI, Concannon P. Human T-cell receptor Vβ gene polymorphism and multiple sclerosis. Am J Hum Genet 1995;56:963-9.
68. Maksymowych WP, Gabriel CA, Luyrink L, Melin-Aldana H, Elma M, Giannini EH, et al. Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics 1992;35:257-62.
69. Luyrink L, Gabriel CA, Thompson SD, Grom AA, Maksymowych WP, Choi E, et al. Reduced expression of a human Vβ 6.1 T-cell receptor allele. Proc Natl Acad Sci U S A 1993;90:4369-73.
70. Frank MB, McArthur R, Harley JB, Fujisaku A. Anti-Ro (SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients. J Clin Invest 1990;85:33-9.
71. Scofield RH, Frank MB, Neas BR, Horowitz RM, Hardgrave KL, Fujisaku A, et al. Cooperative association of T cell beta receptor and HLA-DQ alleles in the production of anti-Ro in systemic lupus erythematosus. Clin Immunol Immunopathol 1994;72:335-41.
72. Scofield RH, Dickey WD, Hardgrave KL, Neas BR, Horowitz RM, McArthur RA, et al. Immunogenetics of epitopes of the carboxyl terminus of the human 60-kD Ro autoantigen. Clin Exp Immunol 1995;99:256-61. Erratum in: Clin Exp Immunol 1995;100:377.
73. Scofield RH, Dickey WD, Hardgrave KL, Neas BR, Horowitz RM, McArthur RA, et al. Immunogenetics of epitopes of the carboxyl terminus of the human 60-kD Ro autoantigen. Clin Exp Immunol 1995;99:256-61. Erratum in: Clin Exp Immunol 1995;100:377.