An autocrine loop mediates expression of vascular endothelial growth factor in human dermal microvascular endothelial cells

Journal of Investigative Dermatology

Volumn 116, Issue 4, 2001, Pages 525-530

  Vega Diaz, Barbara ^a   Herron, G Scott ^a   Michel, Serge ^b  

^a Galderma R and D   (France)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Human dermal microvascular endothelial cells; VEGF

Indexed keywords

CYTOKINE; GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MICROVASCULARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CELL; VASCULAR ENDOTHELIUM;

EID: 0035049357     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01294.x     Document Type: Article

References (45)

1. Interleukin 6 induces the expression of vascular endothelial growth factor
2. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor
3. Molecular regulation of angiogenesis in the skin
4. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
5. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth Factor (VPF/VEGF); and its receptors in human skin
6. Autocrine stimulation of VEGFR- 2 activates human leukemic cell growth and migration
7. Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue
8. Vascular endothelial growth Factor
9. Molecular and biological properties of the vascular endothelial growth Family of proteins
10. SP1 recognition sites in the proximal promoter of the human vascular endothelial growth Factor gene are essential for the platelet-derived growth factor-induced gene expression
11. Angiogenesis in cancer, vascular, rheumatoid and other disease
12. Activation of vascular endothelial growth Factor gene transcription by hypoxia-inducible factor 1
13. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing
14. Transcriptional regnlation of vascular endothelial growth factor gene expression in ovarian bovine granulosa cells
15. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP2 dependent DNA binding and transactivation
16. Formation of endothelial cell networks
17. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
18. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
19. Vascular permeability factor, an endothelial cell mitogen related to PDGF
20. Identification of vascular endothelial growth Factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
21. Activation of the second promoter of the transforming growth factor-beta 1 gene by transfoming growth factor-beta 1 and phorbol ester occurs through the same target sequences
22. Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction
23. Autoinduction of transforming growth factor beta 1 is mediated by the AP- 1 complex
24. Expression of vascular endothelial growth factor by cultured endothelial cells from brain microvessels
25. Vascular endothelial growth factor is a secreted angiogenic mitogen
26. An endothelial cell growth factor from the mouse neuroblastoma cell line NB41
27. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
28. Hypoxia induces vascular endothehal growth factor in cultured human endothelial cells
29. Activation of Sp1-mediated vascular permeability' factor/vascular endothehal growth factor transcription requires specific interaction with protein kinase C zeta
30. Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial growth factor-induced endothelial cell proliferation
31. Vascular endothelial growth factor is expressed in rat corpus luteum
32. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
33. Vascular endothelial growth factor (VEGF) activates Raf-1, mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes
34. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
35. Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
36. Vasculotropin-VEGF stimulates retinal capillary, endothelial cells through an autocrine pathway
37. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
38. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
39. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
40. The human gene for vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing
41. Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor
42. Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells
43. Regulation of vascular endothelial growth factor in human keratinocytes by retinoids
44. Different signal transduction properties of KDR and Flt 1, two receptors for vascular endothelial growth
45. Induction of vascular endothelial growth factor expression in endothelial cells by platetet-derived growth factor through the activation of phosphaddylinositol 3-kinase