Estrogen and Cognition: Applying Preclinical Findings to Clinical Perspectives

Journal of Neuroscience Research

Volumn 74, Issue 5, 2003, Pages 637-643

  Gibbs, Robert B ^a   Gabor, Rachel ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Age related dementia; Alzheimer's disease; Basal forebrain cholinergic neurons; Hormone replacement therapy

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINE ACETYLTRANSFERASE; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTRADIOL; ESTROGEN; GESTAGEN; PROGESTERONE;

AGING; ALZHEIMER DISEASE; BRAIN; CHOLINERGIC NERVE; CHRONOTHERAPY; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; DEMENTIA; DRUG EFFECT; DRUG EFFICACY; ESTROGEN ACTIVITY; ESTROGEN THERAPY; FOREBRAIN; HORMONE SUBSTITUTION; HUMAN; LONG TERM CARE; MAZE TEST; MENTAL PERFORMANCE; NERVE PROJECTION; NONHUMAN; OVARIECTOMY; OVARY FUNCTION; POSTMENOPAUSE; PREDICTION; PRIORITY JOURNAL; PROPHYLAXIS; PUBLIC HEALTH; SHORT SURVEY; SIDE EFFECT; TASK PERFORMANCE; WORKING MEMORY;

AGING; ANIMALS; BRAIN; COGNITION; DEMENTIA; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; RANDOMIZED CONTROLLED TRIALS;

EID: 0345725010     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10811     Document Type: Short Survey

References (37)

1. Baxter MG, Chiba AA. 1999. Cognitive functions of the basal forebrain. Curr Opin Neurobiol 9:178-183.
2. Bimonte HA, Denenberg VH. 1999. Estradiol facilitates performance as working memory load increases. Psychoneuroendocrinology 24:161-173.
3. Brookmeyer R, Gray S, Kawas C. 1998. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Publ Health 88:1337-1342.
4. Daniel JM, Dohanich GP. 2001. Acetylcholine mediates the estrogen-induced increase in NMDA receptor binding in CA1 of the hippocampus and the associated improvement in working memory. J Neurosci 21:6949-6956.
5. Daniel JM, Roberts SL, Dohanich GP. 1999. Effects of ovarian hormones and environment on radial maze and water maze performance of female rats. Physiol Behav 66:11-20.
6. Dohanich GP. 2002. Gonadal steroids, learning and memory. In: Pfaff DW, Arnold AP, Etgen AM, Farbach SE, Rubin RT, editors. Hormones, brain and behavior. San Diego: Academic Press. p 265-327.
7. Everitt BJ, Robbins TW. 1997. Central cholinergic systems and cognition. Annu Rev Psychol 48:649-684.
8. Farquhar CM, Steiner CA. 2002. Hysterectomy rites in the United States 1990-1997. Obstet Gynecol 99:229-234.
9. Gabor R, Nagle R, Johnson DA, Gibbs RB. 2003. Estrogen enhances potassium-stimulated acetylcholine release in the rat hippocampus. Brain Res 962:244-247.
10. Gibbs RB. 1998. Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function. Exp Neurol 151:289-302.
11. Gibbs RB. 1999. Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition. Horm Behav 36:222-233.
12. Gibbs RB. 2000a. Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function. Neuroscience 101:931-938.
13. Gibbs RB. 2000b. Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging 21:107-116.
14. Gibbs RB. 2001. Potential mechanisms for the effects of estrogen on cognitive processes: role of basal forebrain cholinergic projections. In: Handa RJ, Hayashi S, Teresawa E, Kawata M, editors. Neuroplasticity, development, and steroid hormone action. Boca Raton, FL: CRC Press. p 117-129.
15. Gibbs RB. 2002. Basal forebrain cholineroc neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position t-maze task. Horm Behav 42:245-257.
16. Gibbs RB. 2003. Effects of aging, ovariectomy, and long-term hormone replacement on cholinergic neurons in the medial septum and nucleus basalis magnocellularis. J Neuroendocrinol 15:477-485.
17. Gibbs RB, Nelson D, Anthony MS, Clarkson TB. 2002. Effects of long-term hormone replacement and of tibolone on choline acetyltransferase and acetylcholinesterase activities in the brains of ovariectomized cynomologous monkeys. Neuroscience 113(4):907-914.
18. Henderson VW. 2000. Oestrogens and dementia. In: Goode J, editor. Neuronal and cognitive effects of oestrogens (Novartis Found Symp 230). Chichester: Wiley. p 254-273.
19. Hendrie HC. 1998, Epidemiology of dementia and Alzheimer's disease. Am J Geriatr Psychiatry 6(Suppl 1):S3-S18.
20. Hogervorst E, Williams J, Budge M, Riedel W, Jolles J. 2000. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience 101:485-512.
21. Hogervorst E, Yaffe K, Richards M, Huppert F. 2002a. Hormone replacement therapy for cognitive function in postmenopausal women (Cochrane review). Cochrane Database Syst Rev 3.
22. Hogervorst E, Yaffe K, Richards M, Huppert F. 2002b. Hormone replacement therapy to maintain cognitive function in women with dementia (Cochrane review). Cochrane Database Syst Rev 3.
23. Lam TT, Leranth C. 2003. Role of the medial septum diagonal band of Broca cholinergic neurons in oestrogen-induced spine synapse formation on hippocampal CA1 pyramidal cells of female rats. Eur J Neurosci 17:1997-2005.
24. LeBlanc ES, Janowsky J, Chan BKS, Nelson HD. 2001. Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 285:1489-1499.
25. Linstow Ev, Platt B. 1999. Biochemical dysfunction and memory loss: the case of Alzheimer's dementia. Cell Mol Life Sci 55:601-616.
26. Maki P, Hogervorst E. 2003. The menopause and HRT. HRT and cognitive decline. Best Pract Res Clin Endocrinol Metab 17:105-122.
27. Markowska AL, Savonenko AV. 2002. Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats. J Neurosci 22:10985-10995.
28. Matthews KA, Kuller LH, Wing RR, Meilahn EN, Plantinga P. 1996. Prior to use of estrogen replacement therapy, are users healthier than nonusers? Am J Epidemiol 143:971-978.
29. McEwen B. 2002. Estrogen actions throughout the brain. Rec Prog Horm Res 57:357-384.
30. Norbury R, Cutter WJ, Compton J, Robertson DM, Craig M, Whitehead M, Murphy DG. 2003. The neuroprotective effects of estrogen on the aging brain. Exp Gerontol 38:109-117.
31. Rapp PR, Morrison JH, Roberts JA. 2003. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neuroscience 23:5708-5714.
32. Rudick CN, Gibbs RB, Woolley CS. 2003. A role for the basal forebrain cholinergic system in estrogen-induced disinhibition of hippocampal pyramidal cells. J Neurosci 23:4479-4490.
33. Sherwin BB. 2002. Estrogen and cognitive aging in women. Trends Pharmacol Sci 23:527-534.
34. Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, Hendrix SL, Jones BN, 3rd, Assaf AR, Jackson RD, Kotchen JM, Wassertheil-Smoller S, Wactawski-Wende J. 2003. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289:2651-2662.
35. Smith DE, Roberts J, Gage FH, Tuszynski MH. 1999. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci USA 96:10893-10898.
36. Voytko ML. 2002. Estrogen and the cholinergic system modulate visuospatial attention in monkeys (Macaca fascicularis). Behav Neurosci 116:187-197.
37. Zandi PP, Carlson MC, Plassman BL, Welsh-Bohmer KA, Mayer LS, Steffens DC, Breitner JC. 2002. Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County study. JAMA 288:2123-2129.