Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion

Cell Death and Differentiation

Volumn 4, Issue 7, 1997, Pages 608-616

  Umansky, Samuil R ^a   Shapiro, John P ^a   Cuenco, Grace M ^a   Foehr, Matthew W ^a   Bathurst, Ian C ^a   David Tomei, L ^a  

^a LXR Biotechnology Inc   (United States)

Author keywords

Apoptosis; Cardiomyocytes; Ceramide; Ischemia; Phospholipids; Reperfusion

Indexed keywords

EID: 0000705619     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400282     Document Type: Article

References (39)

1. Afanasyev VN, Korol' BA, Mantsygin YA, Nelipovich PA and Umansky SR (1986) Flow cytometry and biochemical analysis of DNA degradation characteristic of two types of cell death. FEBS Letters 194: 347-350
2. Afanasyev VN, Korol' BA, Matylevich NP, Pechatnikov VA and Umansky SR (1993) The use of flow cytometry for the investigation of cell death. Cytometry 14: 603-609
3. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z and Kolesnick R (1995) Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82: 1-20
4. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K and Lefer AM (1995) Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci USA 92: 8031-8035
5. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A and Testi R (1993) Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med. 177: 1547-1552
6. Cohen GM, Sun XM, Snowden RT, Dinsdale D and Skiletter DN (1992) Key morphological features of apoptosis may occur in the absence of intemucleosomal DNA fragmentation. Biochem J. 286: 331-334
7. Dbaibo GS, Obeid LM and Hannun YA (1993) Tumor necrosis factor-α (TNF-α) signal transduction through ceramide. J Biol Chem. 268: 17762-17766
8. Duran GE, Lau DH, Lewis AD, Kuhl JS, Bammler TK and Sikic BI (1966) Differential single-versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues. Cancer Chemother Pharmacol. 38: 210-216
9. Esteve P, del Peso L and Lacal JC (1995) Induction of apoptosis by rho in NIH3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. Oncogene. 11: 2657-2665
10. Fox KAA (1992) Reperfusion injury: laboratory phenomenon or clinical reality? Cardiovasc Res. 26: 656-659
11. Gottlieb RA, Burleson KO, Kloner RA, Babior BM and Engler RL (1994) Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 94: 1621-1628
12. Guo Z, Liliom K, Fischer DJ, Bathurst IC, Tomei LD, Kiefer MC and Tigyi G (1996) Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lyphosphatidic acid from Xenopus oocytes. Proc Natl Acad Sci USA. 93: 14367-14372
13. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLouglin M, Fuks Z and Kolesnick RN (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med. 180: 525-535
14. Hannun YA and Obeid LM (1995) Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 20:73-77
15. Itoh G, Tamura J, Suzuki M, Suzuki Y, Ikeda H, Koike M, Nomura M, Jie T and Ito K (1995) DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol. 146: 1325-1331
16. Jarvis WD, Fornari FA Jr, Browning JL, Gewirtz DA, Kolesnick RN and Grant S (1994) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem. 269: 31685-31692
17. Jayadev S, Liu B, Bielawska EA, Lee JY, Nazaire F, Pushkareva MY, Obeid LM and Hannun YA (1995) Role for ceramide in cell cycle arrest. J Biol Chem. 270: 20472052
18. Karmazyn M (1991) Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions. Can J Physiol Pharmacol. 69: 719-730
19. Kerr JF, Wyllie AH and Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
20. Kolesnick R and Fuks Z (1995) Ceramide: a signal for apoptosis or mitogenesis? J Exp Med. 181: 1949-1952
21. Kolesnick R and Golde DW (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77: 325-328
22. Moolenaar WH (1995) Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem. 270: 12949-12952
23. Nunez G, Merino R, Grillot D and Gonzalez-Garcia (1994) Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today 15: 582-588
24. Obeid LM, Linardic CM, Karolak LA and Hannun Y (1993) Programmed cell death induced by ceramide. Science 259: 1769-1771
25. Olson RD and Mushlin PS (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J. 4: 3076-3086
26. 1-adrenergic receptor interaction: evidence for independent regulation of growth and beating. Circulation Res. 56: 884-894
27. ++ dependent protein kinase. Biochem Biophys Res Comm. 135: 397-402
28. Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA and Seldin MF (1995) Role of ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci USA. 92:8443-8447
29. Thor H, Smith MT, Hartzell P, Bellomo G, Jewell SA and Orrenius S (1982) The metabolism of menadione (2-methyl-1,4-naphtoquinone) by isolated hepatocytes. J Biol Chem. 257: 12419-12425
30. Tigyi G and Miledi R (1992) Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J Biol Chem. 267: 21360-21367
31. Tomei LD, Shapiro JP and Cope FO (1993) Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc Natl Acad Sci USA. 90: 853-857
32. Umansky S (1996) Apoptosis: molecular and cellular mechanisms (a review). Molecular Biology 30: 285-295
33. Umansky SR, Cuenco GM, Khutzian SS, Barr PJ and Tomei LD (1995) Post-ischemic apoptotic death of a rat neonatal cardiomyocytes. Cell Death Differ. 2: 235-241
34. Umansky SR, Pisarenko OI, Serebryakova LI, Studneva IM, Tskitishvili OV, Khutsian SS, Sukhova TI, Lichtenstein AV, Ossina NK, Kiefer MC and Tomei LD (1996) Dog cardiomyocyte death induced in vivo by ischemia and reperfusion. Basic and Applied Myology. 6: 227-235
35. Vaux DL and Strasser A (1996) The molecular biology of apoptosis. Proc Natl Acad Sci USA. 93: 2239-2244
36. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z and Kolesnick RN (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79
37. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA and Brenner DA (1995) Ceramide activates the stress-activated protein kinases. J Biol Chem. 270: 22689-22692
38. Whyta M (1996) ICE/CED-3 proteases in apoptosis. Trends in Cell Biol. 6: 245-248
39. Zamble DB and Lippard SJ (1995) Cisplatin and DNA repair in cancer chemotherapy. Trends Biochem Sci. 20: 435-439