Construction of a cis-Cyclopropane via Reductive Radical Decarboxylation. Enantioselective Synthesis of cis- and trans-1-Arylpiperazyl-2-phenylcyclopropanes Designed as Antidopaminergic Agents

Journal of Organic Chemistry

Volumn 68, Issue 24, 2003, Pages 9255-9262

  Yamaguchi, Kazuya ^a   Kazuta, Yuji ^a   Abe, Hiroshi ^a   Matsuda, Akira ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIMERIZATION; REDUCTIVE DECARBOXYLATION;

HYDRIDES; ISOMERS; MOLECULAR STRUCTURE; REDUCTION; SUBSTRATES; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

1 (2,4 DIMETHYLPHENYL)PIPERAZYLMETHYL 2 PHENYLCYCLOPROPANE; 1 (TERT BUTYLDIPHENYLSILYLOXY)METHYL 2 CARBOXY 2 PHENYLCYCLOPROPANE; AMIDE; CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT; EPICHLOROHYDRIN; ESTER DERIVATIVE; HALOPERIDOL; N HYDROXYPYRIDINE 2 THIONE ESTER; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DECARBOXYLATION; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; EPIMERIZATION; ISOMER; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS;

CYCLOPROPANES; DECARBOXYLATION; DOPAMINE ANTAGONISTS; DRUG DESIGN; HALOPERIDOL; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; STEREOISOMERISM;

EID: 0345686478     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0302206     Document Type: Article

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