메뉴 건너뛰기




Volumn 34, Issue 5, 2003, Pages 475-481

Changes in CD4+ T-Cell Differentiation Phenotype during Structured Treatment Interruption in Patients with Chronic HIV-1 Infection

Author keywords

CD4; HIV 1; Structured treatment interruption; T lymphocytes

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; VIRUS RNA;

EID: 0345490972     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200312150-00005     Document Type: Article
Times cited : (21)

References (35)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med. 1998;338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 0032576426 scopus 로고    scopus 로고
    • Changing patterns of mortality across Europe in patients infected with HIV-1
    • Mocroft A, Vella S, Benfield TL, et al. Changing patterns of mortality across Europe in patients infected with HIV-1. Lancet. 1998;352:1725-1730.
    • (1998) Lancet , vol.352 , pp. 1725-1730
    • Mocroft, A.1    Vella, S.2    Benfield, T.L.3
  • 3
    • 0034645476 scopus 로고    scopus 로고
    • Differential access in the receipt of antiretroviral drugs for the treatment of AIDS and its implications for survival
    • Anderson KH, Mitchell JM. Differential access in the receipt of antiretroviral drugs for the treatment of AIDS and its implications for survival. Arch Intern Med. 2000;160:3114-3120.
    • (2000) Arch Intern Med , vol.160 , pp. 3114-3120
    • Anderson, K.H.1    Mitchell, J.M.2
  • 4
    • 0032953920 scopus 로고    scopus 로고
    • + T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • + T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5:512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3
  • 5
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent viral reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • Ramratnam B, Mittler JE, Zhang L, et al. The decay of the latent viral reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med. 2000;6:82-85.
    • (2000) Nat Med , vol.6 , pp. 82-85
    • Ramratnam, B.1    Mittler, J.E.2    Zhang, L.3
  • 6
    • 0036133364 scopus 로고    scopus 로고
    • Reservoirs of human immunodeficiency virus type 1: The main obstacles to viral eradication
    • Pomerantz RJ. Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication. Clin Infect Dis. 2002;34:91-97.
    • (2002) Clin Infect Dis , vol.34 , pp. 91-97
    • Pomerantz, R.J.1
  • 7
    • 0034727073 scopus 로고    scopus 로고
    • Immune control of HIV-1 after early treatment of acute infection
    • Rosenberg ES, Altfeld M, Poon SH, et al. Immune control of HIV-1 after early treatment of acute infection. Nature. 2000;407:523-526.
    • (2000) Nature , vol.407 , pp. 523-526
    • Rosenberg, E.S.1    Altfeld, M.2    Poon, S.H.3
  • 8
    • 0034711393 scopus 로고    scopus 로고
    • Control of SIV rebound through structured treatment interruptions during early infection
    • Lori F, Lewis MG, Xu J, et al. Control of SIV rebound through structured treatment interruptions during early infection. Science. 2000;290: 1591-1593.
    • (2000) Science , vol.290 , pp. 1591-1593
    • Lori, F.1    Lewis, M.G.2    Xu, J.3
  • 9
    • 0032719664 scopus 로고    scopus 로고
    • HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy
    • Ortiz GM, Nixon DF, Trkola A, et al. HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest. 1999;104:R-13-8.
    • (1999) J Clin Invest , vol.104
    • Ortiz, G.M.1    Nixon, D.F.2    Trkola, A.3
  • 10
    • 0035818544 scopus 로고    scopus 로고
    • Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects
    • Ortiz GM, Wellons M, Brancato J, et al. Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects. Proc Natl Acad Sci USA. 2001;98:13288-13293.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13288-13293
    • Ortiz, G.M.1    Wellons, M.2    Brancato, J.3
  • 12
    • 0345669754 scopus 로고    scopus 로고
    • HIV-specific CTL responses do not prevent early viral rebound and immunological deterioration after STI in chronic HIV infection
    • Seattle. Abstract 538-M
    • van Lunzen J, Frahm N, Schmitz J, et al. HIV-specific CTL responses do not prevent early viral rebound and immunological deterioration after STI in chronic HIV infection. Presented at: 9th Conference on Retroviruses and Opportunistic Infections; 2002; Seattle. Abstract 538-M.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Van Lunzen, J.1    Frahm, N.2    Schmitz, J.3
  • 13
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey RT, Bhat N, Yoder C, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci U S A. 1999;96:15109-15114.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15109-15114
    • Davey, R.T.1    Bhat, N.2    Yoder, C.3
  • 14
    • 0033827321 scopus 로고    scopus 로고
    • Changes in CD4 lymphocyte counts after interruption of therapy in patients with viral failure on protease inhibitor-containing regimens
    • Youle M, Janossy G, Turnbull W, et al. Changes in CD4 lymphocyte counts after interruption of therapy in patients with viral failure on protease inhibitor-containing regimens. AIDS. 2000;14:1717-1720.
    • (2000) AIDS , vol.14 , pp. 1717-1720
    • Youle, M.1    Janossy, G.2    Turnbull, W.3
  • 15
    • 0035876068 scopus 로고    scopus 로고
    • The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection
    • Garcia F, Plana M, Ortiz GM, et al. The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection. AIDS. 2001;15:F29-F40.
    • (2001) AIDS , vol.15
    • Garcia, F.1    Plana, M.2    Ortiz, G.M.3
  • 16
    • 0033827460 scopus 로고    scopus 로고
    • Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression
    • Orenstein JM, Bhat N, Yoder C, et al. Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression. AIDS. 2000;14:1709-1715.
    • (2000) AIDS , vol.14 , pp. 1709-1715
    • Orenstein, J.M.1    Bhat, N.2    Yoder, C.3
  • 17
    • 0031882434 scopus 로고    scopus 로고
    • Biphasic kinetics of peripheral blood T-cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
    • Pakker NG, Notermans DW, de Boer RJ, et al. Biphasic kinetics of peripheral blood T-cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med. 1998;4:208-214.
    • (1998) Nat Med , vol.4 , pp. 208-214
    • Pakker, N.G.1    Notermans, D.W.2    De Boer, R.J.3
  • 18
    • 0032741277 scopus 로고    scopus 로고
    • Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissue
    • Bucy RP, Hockett RD, Derdeyn CA, et al. Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissue. J Clin Invest. 1999;103:1391-1398.
    • (1999) J Clin Invest , vol.103 , pp. 1391-1398
    • Bucy, R.P.1    Hockett, R.D.2    Derdeyn, C.A.3
  • 19
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al. J. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997;277:112-116.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 20
    • 0032128437 scopus 로고    scopus 로고
    • In vivo analysis of Fas/FasL interactions in HIV-infected patients
    • Badley AD, Dockrell DH, Algeciras A, et al. In vivo analysis of Fas/FasL interactions in HIV-infected patients. J Clin Invest. 1998; 102:79-87.
    • (1998) J Clin Invest , vol.102 , pp. 79-87
    • Badley, A.D.1    Dockrell, D.H.2    Algeciras, A.3
  • 21
    • 0033568304 scopus 로고    scopus 로고
    • Markers of lymphocyte homing distinguish CD4 T cell subsets that turn over in response to HIV-1 infection in humans
    • Hengel RL, Jones BM, Kennedy MS, et al. Markers of lymphocyte homing distinguish CD4 T cell subsets that turn over in response to HIV-1 infection in humans. J Immunol. 1999;163:3539-3548.
    • (1999) J Immunol , vol.163 , pp. 3539-3548
    • Hengel, R.L.1    Jones, B.M.2    Kennedy, M.S.3
  • 22
    • 0035399662 scopus 로고    scopus 로고
    • CD4+ T-cells programmed to traffic to lymph nodes account for increases in numbers of CD4+ T-cells up to 1 year after initiation of highly active antiretroviral therapy for human immunodeficiency virus type 1 infection
    • Hengel RL, Jones BM, Kennedy MS, et al. CD4+ T-cells programmed to traffic to lymph nodes account for increases in numbers of CD4+ T-cells up to 1 year after initiation of highly active antiretroviral therapy for human immunodeficiency virus type 1 infection. J Infect Dis. 2001;183: 93-97.
    • (2001) J Infect Dis , vol.183 , pp. 93-97
    • Hengel, R.L.1    Jones, B.M.2    Kennedy, M.S.3
  • 23
    • 0035575775 scopus 로고    scopus 로고
    • Evidence for increased T cell turnover and decreased thymic output in HIV infection
    • Douek DC, Betts MR, Hill BJ, et al. Evidence for increased T cell turnover and decreased thymic output in HIV infection. J Immunol. 2001;167: 6663-6668.
    • (2001) J Immunol , vol.167 , pp. 6663-6668
    • Douek, D.C.1    Betts, M.R.2    Hill, B.J.3
  • 24
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Förster R, et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Förster, R.3
  • 25
    • 0037159928 scopus 로고    scopus 로고
    • Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions
    • Schweighardt B, Ortiz GM, Grand RM, et al. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS. 2002;16:2342-2344.
    • (2002) AIDS , vol.16 , pp. 2342-2344
    • Schweighardt, B.1    Ortiz, G.M.2    Grand, R.M.3
  • 26
    • 0035282444 scopus 로고    scopus 로고
    • Skewed maturation of memory HIV-specific CD8 T lymphocytes
    • Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-111.
    • (2001) Nature , vol.410 , pp. 106-111
    • Champagne, P.1    Ogg, G.S.2    King, A.S.3
  • 27
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396: 690-695.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 28
    • 0000228695 scopus 로고    scopus 로고
    • Pre-HAART HIV burden approximates post-HAART viral levels following interruption of therapy in patients with sustained viral suppression
    • Hatano H, Vogel S, Yoder C, et al. Pre-HAART HIV burden approximates post-HAART viral levels following interruption of therapy in patients with sustained viral suppression. AIDS. 2000;14:1357-1363.
    • (2000) AIDS , vol.14 , pp. 1357-1363
    • Hatano, H.1    Vogel, S.2    Yoder, C.3
  • 29
    • 0036468120 scopus 로고    scopus 로고
    • CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
    • Deeks SG, Hoh R, Grant RM, et al. CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy. J Infect Dis. 2002;185:315-323.
    • (2002) J Infect Dis , vol.185 , pp. 315-323
    • Deeks, S.G.1    Hoh, R.2    Grant, R.M.3
  • 30
    • 0035873208 scopus 로고    scopus 로고
    • Immunologic profile of human immunodeficiency virus-infected patient during viral remission and relapse on antiretroviral therapy
    • Wellons MF, Ottinger JS, Weinhold KJ, et al. Immunologic profile of human immunodeficiency virus-infected patient during viral remission and relapse on antiretroviral therapy. J Infect Dis. 2001; 183:1522-1525.
    • (2001) J Infect Dis , vol.183 , pp. 1522-1525
    • Wellons, M.F.1    Ottinger, J.S.2    Weinhold, K.J.3
  • 31
    • 0034948377 scopus 로고    scopus 로고
    • Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
    • Stoddart CA, Liegler TJ, Mammano F, et al. Impaired replication of protease inhibitor-resistant HIV-1 in human thymus. Nat Med. 2001;7:712-718.
    • (2001) Nat Med , vol.7 , pp. 712-718
    • Stoddart, C.A.1    Liegler, T.J.2    Mammano, F.3
  • 33
    • 0035910032 scopus 로고    scopus 로고
    • Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virulogic, immunologic, and toxicity parameters
    • Dybul M, Chun T, Yoder C, et al. Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virulogic, immunologic, and toxicity parameters. Proc Natl Acad Sci U S A. 2001;98:15161-15166.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15161-15166
    • Dybul, M.1    Chun, T.2    Yoder, C.3
  • 34
    • 0035864943 scopus 로고    scopus 로고
    • Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    • Deeks SG, Wrin T, Liegler T, et al. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med. 2001;344:472-480.
    • (2001) N Engl J Med , vol.344 , pp. 472-480
    • Deeks, S.G.1    Wrin, T.2    Liegler, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.