메뉴 건너뛰기




Volumn 6, Issue 4, 2003, Pages 395-399

Cachexia and obesity: Two sides of one coin?

Author keywords

Anorexigenic signal; Cachexia; Cytokine; Leptin; Obesity; Orexigenic signal

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; ANOREXIGENIC AGENT; APPETITE STIMULANT; CILIARY NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; LEUKEMIA INHIBITORY FACTOR; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0345443373     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200307000-00007     Document Type: Review
Times cited : (34)

References (42)
  • 1
    • 0023118407 scopus 로고
    • Cachectin: More than a tumor necrosis factor
    • Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. N Engl J Med 1987; 316:379-385.
    • (1987) N Engl J Med , vol.316 , pp. 379-385
    • Beutler, B.1    Cerami, A.2
  • 3
    • 2042450377 scopus 로고    scopus 로고
    • Pratical concepts for clinicians
    • Bruera E, Higginson I, editors. Oxford: Oxford University Press
    • Higginson I, Bruera E. Pratical concepts for clinicians. In: Bruera E, Higginson I, editors. Cachexia-anorexia in cancer patients. Oxford: Oxford University Press; 1996. pp. 185-189.
    • (1996) Cachexia-anorexia in Cancer Patients , pp. 185-189
    • Higginson, I.1    Bruera, E.2
  • 4
    • 0030688961 scopus 로고    scopus 로고
    • Anorexia, cachexia, and nutrition
    • Bruera E. Anorexia, cachexia, and nutrition. BMJ 1997; 315:1219-1222.
    • (1997) BMJ , vol.315 , pp. 1219-1222
    • Bruera, E.1
  • 6
    • 0036198117 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Current issues in research and management
    • Inui A. Cancer anorexia-cachexia syndrome: Current issues in research and management. Ca Cancer J Clin 2002; 52:72-91. This presents an overview of research and pharmacological manipulation of appetite and other central and peripheral mechanisms involved in cachectic processes.
    • (2002) Ca Cancer J Clin , vol.52 , pp. 72-91
    • Inui, A.1
  • 7
    • 0033567912 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Are neuropeptides the key?
    • Inui A. Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer Res 1999; 59:4493-4501.
    • (1999) Cancer Res , vol.59 , pp. 4493-4501
    • Inui, A.1
  • 8
    • 0030665384 scopus 로고    scopus 로고
    • Biology of cachexia
    • Tisdale MJ. Biology of cachexia. J Natl Cancer Inst 1997; 89:1763-1773.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1763-1773
    • Tisdale, M.J.1
  • 9
    • 0035000097 scopus 로고    scopus 로고
    • Cancer anorexia and cachexia
    • Tisdale MJ. Cancer anorexia and cachexia. Nutrition 2001; 17:438-442.
    • (2001) Nutrition , vol.17 , pp. 438-442
    • Tisdale, M.J.1
  • 10
    • 0031004362 scopus 로고    scopus 로고
    • Proinflammatory cytokines, nutritional support, and the cachexia syndrome: Interactions and therapeutic options
    • Moldawer LL, Copeland EM 3rd. Proinflammatory cytokines, nutritional support, and the cachexia syndrome: Interactions and therapeutic options. Cancer 1997; 79:1828-1839.
    • (1997) Cancer , vol.79 , pp. 1828-1839
    • Moldawer, L.L.1    Copeland III, E.M.2
  • 11
    • 0033771667 scopus 로고    scopus 로고
    • Central nervous system mechanisms contributing to the cachexia-anorexia syndrome
    • Plata-Salaman CR. Central nervous system mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 2000; 16:1009-1012.
    • (2000) Nutrition , vol.16 , pp. 1009-1012
    • Plata-Salaman, C.R.1
  • 12
    • 0033781030 scopus 로고    scopus 로고
    • Hypothalamic dopamine and serotonin in the regulation of food intake
    • Meguid MM, Fetissov SO, Varma M, et al. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 2000; 16:843-857.
    • (2000) Nutrition , vol.16 , pp. 843-857
    • Meguid, M.M.1    Fetissov, S.O.2    Varma, M.3
  • 15
    • 0035451059 scopus 로고    scopus 로고
    • Cytokines and sickness behavior: Implications from knockout animal models
    • Inui A. Cytokines and sickness behavior: Implications from knockout animal models. Trends Immunol 2001; 22:469-473.
    • (2001) Trends Immunol , vol.22 , pp. 469-473
    • Inui, A.1
  • 16
    • 0035165407 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior: Where do we stand?
    • Dantzer R. Cytokine-induced sickness behavior: where do we stand? Brain Behav Immun 2001; 15:7-24.
    • (2001) Brain Behav Immun , vol.15 , pp. 7-24
    • Dantzer, R.1
  • 17
    • 0035983488 scopus 로고    scopus 로고
    • Anticancer drugs that induce cancer-associated cachectic syndromes
    • Tohgo A, Kumazawa E, Akahane K, et al. Anticancer drugs that induce cancer-associated cachectic syndromes. Expert Rev Anticancer Ther 2002; 2:121-129.
    • (2002) Expert Rev Anticancer Ther , vol.2 , pp. 121-129
    • Tohgo, A.1    Kumazawa, E.2    Akahane, K.3
  • 18
    • 0031456504 scopus 로고    scopus 로고
    • Neural-immune interactions in health and disease
    • Sternberg EM. Neural-immune interactions in health and disease. J Clin Invest 1997; 100:2641-2647.
    • (1997) J Clin Invest , vol.100 , pp. 2641-2647
    • Sternberg, E.M.1
  • 19
    • 0028918740 scopus 로고
    • Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats
    • Opara EI, Laviano A, Meguid MM, Yang ZJ. Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats. Neuroreport 1995; 6:750-752.
    • (1995) Neuroreport , vol.6 , pp. 750-752
    • Opara, E.I.1    Laviano, A.2    Meguid, M.M.3    Yang, Z.J.4
  • 20
    • 0029145687 scopus 로고
    • Temporal changes in meal number and meal size relationship in response to rHu IL-1 alpha
    • Debonis D, Meguid MM, Laviano A, et al. Temporal changes in meal number and meal size relationship in response to rHu IL-1 alpha. Neuroreport 1995; 6:1752-1756.
    • (1995) Neuroreport , vol.6 , pp. 1752-1756
    • Debonis, D.1    Meguid, M.M.2    Laviano, A.3
  • 21
    • 0033536008 scopus 로고    scopus 로고
    • Leptin actions on food intake and body temperature are mediated by IL-1
    • Luheshi GN, Gardner JD, Rushforth DA, et al. Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A 1999; 96:7047-7052.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7047-7052
    • Luheshi, G.N.1    Gardner, J.D.2    Rushforth, D.A.3
  • 22
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 23
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature 2000; 404:661-671.
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1    Woods, S.C.2    Porte Jr., D.3
  • 24
    • 0034048279 scopus 로고    scopus 로고
    • Transgenic approach to the study of body weight regulation
    • Inui A. Transgenic approach to the study of body weight regulation. Pharmacol Rev 2000; 52:35-61.
    • (2000) Pharmacol Rev , vol.52 , pp. 35-61
    • Inui, A.1
  • 25
    • 0031578276 scopus 로고    scopus 로고
    • Neuroendocrine responses to starvation and weight loss
    • Schwartz MW, Seeley RJ. Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997; 336:1802-1811.
    • (1997) N Engl J Med , vol.336 , pp. 1802-1811
    • Schwartz, M.W.1    Seeley, R.J.2
  • 26
    • 0028243943 scopus 로고
    • Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats
    • Chance WT, Balasubramaniam A, Dayal R, et al. Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats. Life Sci 1994; 54:1869-1874.
    • (1994) Life Sci , vol.54 , pp. 1869-1874
    • Chance, W.T.1    Balasubramaniam, A.2    Dayal, R.3
  • 27
  • 28
    • 0037462298 scopus 로고    scopus 로고
    • Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia
    • Makarenko I, Meguid MM, Gatto L, et al. Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Brain Res 2002; 961:100-108.
    • (2002) Brain Res , vol.961 , pp. 100-108
    • Makarenko, I.1    Meguid, M.M.2    Gatto, L.3
  • 30
    • 0035866377 scopus 로고    scopus 로고
    • Role of the central melanocortin system in cachexia
    • Marks DL, Ling N, Cone RD. Role of the central melanocortin system in cachexia. Cancer Res 2001; 61:1432-1438.
    • (2001) Cancer Res , vol.61 , pp. 1432-1438
    • Marks, D.L.1    Ling, N.2    Cone, R.D.3
  • 31
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • Wisse BE, Frayo RS, Schwartz MW, Cummings DE. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 2001; 142:3292-3301.
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 33
    • 0034611784 scopus 로고    scopus 로고
    • Medicinal strategies in the treatment of obesity
    • Bray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity. Nature 2000; 404:672-677.
    • (2000) Nature , vol.404 , pp. 672-677
    • Bray, G.A.1    Tartaglia, L.A.2
  • 34
    • 0030272823 scopus 로고    scopus 로고
    • Cracking the riddle of cancer anorexia
    • Laviano A, Meguid MM, Yang ZJ, et al. Cracking the riddle of cancer anorexia. Nutrition 1996; 12:706-710.
    • (1996) Nutrition , vol.12 , pp. 706-710
    • Laviano, A.1    Meguid, M.M.2    Yang, Z.J.3
  • 35
    • 0035064287 scopus 로고    scopus 로고
    • Managing cancer-related anorexia/cachexia
    • Mantovani G, Maccio A, Massa E, Madeddu C. Managing cancer-related anorexia/cachexia. Drugs 2001; 61:499-514.
    • (2001) Drugs , vol.61 , pp. 499-514
    • Mantovani, G.1    Maccio, A.2    Massa, E.3    Madeddu, C.4
  • 36
    • 0000879468 scopus 로고    scopus 로고
    • Cachexia-anorexia workshop summary and conclusions
    • MacDonald N. Cachexia-anorexia workshop summary and conclusions. Nutrition 2000; 16:1019-1020.
    • (2000) Nutrition , vol.16 , pp. 1019-1020
    • MacDonald, N.1
  • 37
    • 0035430665 scopus 로고    scopus 로고
    • Ghrelin: An orexigenic and somatotrophic signal from the stomach
    • Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001; 2:551-560.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 551-560
    • Inui, A.1
  • 38
    • 0035836760 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
    • Lambert PD, Anderson KD, Sleeman MW, et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A 2001; 98:4652-4657.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4652-4657
    • Lambert, P.D.1    Anderson, K.D.2    Sleeman, M.W.3
  • 39
    • 0037370258 scopus 로고    scopus 로고
    • The emerging science of body weight regulation and its impact on obesity treatment
    • Korner J, Aronne LJ. The emerging science of body weight regulation and its impact on obesity treatment. J Clin Invest 2003; 111:565-570.
    • (2003) J Clin Invest , vol.111 , pp. 565-570
    • Korner, J.1    Aronne, L.J.2
  • 40
    • 0036528005 scopus 로고    scopus 로고
    • Obesity therapy: Altering the energy intake-and-expenditure balance sheet
    • Crowley VE, Yeo GS, O'Rahilly S. Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nat Rev Drug Discov 2002; 1:276-286. This informative paper describes obesity therapy by altering the balance between energy intake and expenditure.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 276-286
    • Crowley, V.E.1    Yeo, G.S.2    O'Rahilly, S.3
  • 41
    • 0036632632 scopus 로고    scopus 로고
    • Central mechanisms involved with catabolism
    • Nandi J, Meguid MM, Inui A, et al. Central mechanisms involved with catabolism. Curr Opin Clin Nutr Metab Care 2002; 5:407-418. This is a review of central mechanisms involved with catabolism, describing a variety of neurohormonal, monoaminergic and peptidergic mediators.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , pp. 407-418
    • Nandi, J.1    Meguid, M.M.2    Inui, A.3
  • 42
    • 0036830917 scopus 로고    scopus 로고
    • Cachexia in cancer patients
    • Tisdale MJ. Cachexia in cancer patients. Nat Rev Cancer 2002; 2:862-871. This is a review on catabolic factors acting to destroy host tissues such as muscle and fat.
    • (2002) Nat Rev Cancer , vol.2 , pp. 862-871
    • Tisdale, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.