Involvement of thiol metabolism in resistance to glucantime in Leishmania tropica

Biochemical Pharmacology

Volumn 56, Issue 9, 1998, Pages 1201-1208

  Arana, Flora E ^a   Pérez Victoria, José M ^a   Repetto, Yolanda ^b   Morello, Antonio ^b   Castanys, Santiago ^a   Gamarro, Francisco ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Buthionine sulfoximine; Chlorambucil; Extrachromosomal element; Leishmania tropica; Resistance to Glucantime; Thiol metabolism

Indexed keywords

ANTIMONY DERIVATIVE; BUTHIONINE SULFOXIMINE; CHLORAMBUCIL; GLUTAMATE CYSTEINE LIGASE; GLYCOPROTEIN P; MEGLUMINE ANTIMONATE; ORNITHINE DECARBOXYLASE; THIOL; TRYPANOTHIONE;

ARTICLE; CELL LINE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEISHMANIA TROPICA; LEISHMANIASIS; METABOLISM; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

ANIMALS; ANTIPROTOZOAL AGENTS; BUTHIONINE SULFOXIMINE; CHLORAMBUCIL; DRUG RESISTANCE; LEISHMANIA TROPICA; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; SULFHYDRYL COMPOUNDS;

EID: 0345055821     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00129-4     Document Type: Article

References (44)

1. Berman JD, Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies. Rev of Infecti Dis 10: 560-586, 1988.
2. Thakur CP, Kumar M, and Pandey AK, Comparison of regimens of treatment of antimony- resistant visceral leishmaniasis patients: a randomized study. Am J Trop Med Hyg 45: 435-441, 1991.
3. Grogl M, Ayoade MJ, Lawrence DC, and Kyle DE, Leishmania spp., Development of Pentostam-resistant clones in vitro by discontinuous drug exposure. Exp Parasitol 69: 78-90, 1989.
4. Berman JD, Edwards N, King M, and Grogl M, Biochemistry of Pentostam-resistant Leishmania. Am J Trop Med Hyg 40: 159-164, 1989.
5. Berman JD, Chulay JD, Hendricks LD, and Oster CN, Susceptibility of clinically sensitive and resistant Leishmania to pentavalent antimony in vitro. Am J Trop Med 31: 459-465, 1982.
6. Ouellette M and Papadopoulou B, Mechanisms of drug resistance in Leishmania. Parasitol Today 9: 150-153, 1993.
7. Borst P and Ouellette M, New mechanisms of drug resistance in parasitic protozoa. Annu Rev Microbiol 49: 427-460, 1995.
8. Gutteridge WE and Coombs GH, Biochemistry of parasitic protozoa. Macmillan and Co., London, 1977.
9. Grogl M, Martin RK, Oduola A, Milhous W, and Kyle D, Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components. Am J Trop Med Hyg 45: 98-111, 1992.
10. Dey S, Ouellette M, Lightbody J, Papadopoulou B, and Rosen BP, An ATP-dependent As(III)-glutathione transport system in membrane-vesicles of Leishmania tarentolae. Proc Natl Acad Sci USA 93: 2192-2197, 1996.
11. Mukhopadhyay R, Dey S, Xu N, Gage D, Lightbody J, Ouellette M, and Rosen BP, Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Proc Natl Acad Sci USA 93: 10383-10387, 1996.
12. Aldunate J and Morello A, Free radicals in the mode of action of antiparasitic drugs. In: Free Radicals in Tropical Medicine (Ed. Aruoma, OI), pp. 137-165. Harwood Academic Publishers, London, 1993.
13. Fairlamb AH and Cerami A, Metabolism and functions of trypanothione in the kinetoplastidia. Annu Rev Microbiol 46: 695-729. 1992.
14. Morello A, The biochemistry of the mode of action of drugs and the detoxification mechanisms in Trypanosoma cruzi. Comp Biochem Physiol 90: 1-12, 1988.
15. Moncada C, Repetto Y, Aldunate J, Letelier ME, and Morello A, Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs. Comp Biochem Physiol 94C: 87-91, 1989.
16. Repetto Y, Opazo E, Maya JD, Agosin M, and Morello A, Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs. Comp Biochem Physiol 115B: 281-285, 1996.
17. Maya JD, Repetto Y, Agosin M, Ojeda JM, Tellez R, Gaule C, and Morello A, Effects of Nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi. Mol Biochem Parasitol 86: 101-106, 1997.
18. Grondin K, Haimeur A, Mukhopadhyay R, Rosen BP, and Ouellette M, Co-amplification of the γ-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene PgpA in arsenite-resistant Leishmania tarentolae. EMBO Journal 16: 3057-3065, 1997.
19. Jackson PR, Lawrie JM, Stiteler JM, Hawkins DW, Wohlhieter JA, and Rowtin ED, Detection and characterization of Leishmania species and strains from mammals and vectors by hybridization and restriction endonuclease digestion of kinetoplast DNA. Veter Parasitol 20: 195-215, 1986.
20. Chiquero MJ, Olmo A, Navarro P, Ruiz-Perez LM, Castanys S, Gonzalez-Pacanowska D, and Gamarro F, Amplification of the locus H in Leishmania infantum. Biochim et Biophys Acta 1227: 188-194, 1994.
21. Fairlamb AH, Henderson GB, Bacchi CJ, and Ceramia A, In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol 24: 185-191, 1987.
22. Coderre JA, Beverley SM, Schimke RT, and Santi DV, Overproduction of a bifunctional thymidylate synthase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci USA 80: 2132-2136, 1983.
23. Sambrook J, Fristch EF and Maniatis T, Molecular Cloning- A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory Press, Plainview, New York, 1989.
24. Chomczynski P and Sacchi N, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
25. Aviv H and Leder P, Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci USA 69: 1408-1412, 1972.
26. Hanson S, Adelman J, and Ullman B, Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani. J Biol Chem 267: 2350-2359,1992.
27. Taylor MC, Kelly JM, Chapman CJ, Fairlamb AH, and Miles MA, The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase. Mol Biochem Parasitol 64: 293-301, 1994.
28. Chiquero MJ, Perez-Victoria JM, O'Valle F, Gonzalez-Ros JM, del Moral R, Ferragut J, Castanys S, and Gamarro F, Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line. Biochem Pharmacol 55: 131-139, 1998.
29. Ouellette M, Fase-Fowler F, and Borst P, The amplified H circle of methotrexate- resistant Leishmania tarentolae contains a novel P-glycoprotein gene. EMBO J 9: 1027-1033, 1990.
30. Chu G, Vollrath D, and Davis RW, Separation of large DNA molecules by contour-clamped homogeneous electric field. Science 234: 1582-1585, 1986.
31. Birnboim HC, A rapid alkaline extraction method for the isolation of plasmid DNA. Methods Enzymol 100: 243-255, 1983.
32. Meister A, Selective modification of glutathione metabolism. Science 220: 472-477, 1983.
33. Ciaccio PJ, Tew KD, and LaCreta FP, The spontaneous and glutathione S-transferase- mediated reaction of chlorambucil with glutathione. Cancer Commun. 8: 279-285, 1990.
34. Beverley SM, Gene amplification in Leishmania. Ann Rev Microbiol 45: 417-444, 1991.
35. Moreira ES, Guerra JB, and Petrillo-Peixoto ML, Glucantime-resistant Leishmania promastigotes are sensitive to pentostam. Rev Soc Bras Med Trop 25: 247-250, 1992.
36. Ullman B, Carrero-Valenzuela E and Coons T, Leishmania donovani: isolation and characterization of sodium stibogluconate (Pentostam)-resistant cell lines. Exp Parasitol 69: 157-163, 1989.
37. Steemkamp DJ and Spies HSC, Identification of a major low-molecular-mass thiol of the Trypanosomatid Crithidia fasciculata as ovothiol A. Facile isolation and structural analyses of the bimane derivative. Eur J Biochem 223: 43-50, 1994.
38. Spies HSC and Steemkamp DJ, Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structure analysis of a novel thiol from Mycobacterium bovis. Eur J Biochem 224: 203-213, 1994.
39. Leier I, Jedlitschky G, Buchholz U, Cole SPC, Deeley RG, and Kepler D, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269: 27807-27810, 1994.
40. Müller M, Meijer C, Zaman GJR, Borst P, Sheper RJ, Mulder NH, De Vries EGE, and Jansen PLM, Overexpression of the gene encoding the multidrug-resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91: 13033-13037, 1994.
41. Cole SP, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM, and Deely RG, Pharmacological characterization of multidrug-resistant MRP-transfected human tumor cells. Cancer Res 54: 5902-5910, 1994.
42. Dey S, Papadopoulou B, Roy G, Grondin K, Dou D, Rosen BP, and Ouellette M, High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system. Mol Biochem Parasitol 67: 49-57, 1994.
43. Papadopoulou B, Roy G, Dey S, Rosen BP, and Ouellette M, Contribution of the Leishmania P-glycoprotein-related gene LtpgpA to oxyanion resistance. J Biol Chem 269: 11980-11986, 1994.
44. Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, and Ullman B, Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdrl gene. Mol Cell Biol 12: 2855-2865, 1992.