Drug resistance in Pneumocystis carinii: an emerging problem

Drug Resistance Updates

Volumn 1, Issue 3, 1998, Pages 201-204

  Walker, Daniel J ^a   Meshnick, Steven R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0345026217     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-7646(98)80040-X     Document Type: Review

References (49)

1. http://www.cdc.gov/nchstp/hiv_aids/graphics/images/surveill/1178_16.htm
2. Hoover D.R., Saah A.J., Bacillar H., et al. Clinical manifestations of AIDS in the era of Pneumocystis prophylaxis. N Engl J Med 329 (1993) 1922-1926
3. Edman J.C., Kovacs J.A., Masur H., et al. Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature (London) 334 (1988) 519-522
4. Edman J.C., Edman U., Cao M., et al. Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc Natl Acad Sci USA 86 (1989) 8625-8629
5. Stringer S.L., Hudson K., Blase M.A., et al. Sequence from ribosomal RNA of Pneumocystis carinii compared to those of four fungi suggests an ascomycetous affinity. J Protozool 36 (1989) 14S-16S
6. Watanabe J., Hori H., Tanabe K., and Nakamura Y. Phylogenetic association of Pneumocystis carinii with the 'Rhizopoda/Myxomycota/Zygomycota group' indicated by comparison of 5S ribosomal RNA sequences. Mol Biochem Parasitol 32 (1989) 163-167
7. Pixley F.J., Wakefield A.E., Banerji S., and Hopkin J.M. Mitochondrial gene sequences show fungal homology for Pneumocystis carinii. Mol Microbiol 5 (1991) 1347-1351
8. Pneumocystis Workshop. Revised nomenclature for Pneumocystis carinii. J Euk Microbiol 41 (1994) 121S-122S
9. Keely S., Pai H.J., Baughman R., et al. Pneumocystis species inferred from analysis of multiple genes. J Euk Microbiol 41 (1994) 94S
10. Stringer J.R. Pneumocystis carinii: what is it, exactly?. Clin Microbiol Rev 9 (1996) 489-498
11. Smulian A.G., Keely S.P., Sunkin S.M., and Stringer J.R. Genetic and antigenic variation in Pneumocystis carinii organisms: tools for examining the epidemiology and pathogenesis of infection. J Lab Clin Med 130 (1997) 461-468
12. Lee C.H., Lu J.J., Barlett M.S., et al. Nucleotide sequence variation in Pneumocystis carinii strains that infect humans. J Clin Microbiol 31 (1993) 754-757
13. Wakefield A.E., Fritscher C.C., Malin A.S., et al. Genetic diversity in human-derived Pneumocystis carinii isolates from four geographical locations shown by analysis of mitochondrial rRNA gene sequences. J Clin Microbiol 32 (1994) 2959-2961
14. Keely S.P., Stringer J.R., Baughman R.P., et al. Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. J Infect Dis 172 (1995) 595-598
15. Latouche S., Ortona E., Mazars E., et al. Biodiversity of Pneumocystis carinii hominis: typing with different DNA regions. J Clin Microbiol 35 (1997) 383-387
16. Centers for Disease Control and Prevention. 1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. MMWR.
17. Walzer P.D., Foy J., Steele P., et al. Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 36 (1992) 1935-1942
18. Kunz S., Junker U., Blaser, et al. The scid mouse as an experimental model for the evaluation of anti-Pneumocystis carinii therapy. J Antimicrob Chemother 36 (1995) 137-155
19. Hughes W.T., and Killmar J. Is trimethoprim of trimethoprim/sulfamethoxazole (TMP/SMX) necessary for Pneumocystis carinii pneumonia (PCP) prophylaxis?. (Po 289) Fourth Congress on Retroviruses and Opportunistic infections (1997) 117
20. Bozzette S.A., Finkelstein D.M., Spector S.A., et al. A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. N Engl J Med 332 (1995) 693-699
21. Simonds R.J., Hughes W.T., Feinberg J., and Navin T.R. Preventing Pneumocystis carinii pneumonia in persons infected with human immunodeficiency virus. Clin Infect Dis 21 suppl 1 (1995) S44-S48
22. Voeller D., Kovacs J., Andrawis V., et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone). J Infect Dis 169 (1994) 456-459
23. Spencer C., and Goa K. Atovaquone - a review of its pharmacological properties and therapeutic efficacy in opportunistic infections. Drugs 50 (1995) 176-196
24. Lane B.R., Ast J.C., Hossler P.A., et al. Dihydropteroate synthase polymorphisms in Pneumocystis carinii. J Infect Dis 175 (1997) 482-485
25. Kazanjian P., Locke A.B., Hossler P.A., et al. Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients. AIDS 12 (1998) 873-878
26. Walker DJ, Wakefield AE, Dohn MN et al. Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone failure. Submitted.
27. Fry M., and Pudney M. Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4′-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566c80). Biochem Pharmacol 43 (1992) 1545-1553
28. Ittarat I., Asawamahasakda W., and Meshnick S.R. The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp Parasitol 79 (1994) 50-56
29. Ittarat I., Asawamahaskda W., Bartlett M.S., et al. Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase. Antimicrob Agents Chemother 39 (1995) 325-328
30. Achari A., Somers D.O., Champness J.N., et al. Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nature Structural Biology 4 (1997) 490-497
31. Brown G.M. The biosynthesis of folic acid. II. Inhibition by sulfonamides. J Biol Chem 237 (1962) 536-540
32. Sammes P.G. Sulfonamides and sulfones. In: Sammes P.G. (Ed). Comprehensive Medicinal Chemistry 2 (1990), Pergamon Press, Oxford 255-270
33. Vedantam G., Guay G.G., Austria N.E., et al. Characterization of mutations contributing to sulfathiazole resistance is Escherichia coli. Antimicrob Agents Chemother 42 (1998) 88-93
34. Lopez P., Espinosa M., Greenberg B., and Lacks S.A. Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme. J Bacteriol 169 (1987) 4320-4326
35. Brooks D.R., Wang P., Read M., et al. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfa. Eur J Biochem 224 (1994) 397-405
36. Vaidya A.B., Lashgari M.S., Pologe L.G., and Morrisey J. Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones. Mol Biochem Parasitol 58 (1993) 33-42
37. Degli Esposti M., DeVries S., Crimi M., et al. Mitochondrial cytochrome b: evolution and structure of the protein. Biochim Biophys Acta 1143 (1993) 243-271
38. Brandt U., and Trumpower B. The protonmotive Q cycle in mitochondria and bacteria. Crit Rev Biochem Mol Biol 29 (1994) 165-197
39. 1 complex. Biochim Biophys Acta 1275 (1996) 61-69
40. Albers B., Bray D., Lewis J., et al. Molecular biology of the cell. 2nd ed. (1989), Garland Publishing, Inc, New York 393
41. Safwat G., and Rathod P.K. Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance. Antimicrob Agents Chemother 40 (1996) 914-919
42. Canfield C.J., Pudney M., and Gutteridge W.E. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol 80 (1995) 373-381
43. Yeo A., Seymour K.K., Rieckmann K.H., and Christopherson R.I. Effects of dual combinations of antifolates with atovaquone or dapsone on nucleotide levels in Plasmodium falciparum. Biochem Pharm 53 (1997) 943-950
44. Volpe F., Ballantine S.P., and Delves C.J. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase. Eur J Biochem 216 (1993) 449-458
45. Volpe F., Dyer M., Scaife J.G., et al. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase. Gene 112 (1992) 213-218
46. abstract. Lane B., Hossler P., Bartlett M., et al. Sulfa resistance in mouse-derived Pneumocystis carinii. J Euk Microbiol 43 (1996) 39S
47. Mei Q, Gurunathan S, Masur H, Kovacs JA. Trimethoprim-sulfamethoxazole failure in Pneumocystis carinii infection associated with mutations in the dihydropteroate synthase gene. Submitted.
48. 1 complex of Rhodobacter capsulatus. EMBO J 8 (1989) 3951-3961
49. Howell N., and Gilbert K. Mutational analysis of the mouse mitochondrial cytochrome b gene. J Mol Biol 203 (1988) 607-618