Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients

AIDS

Volumn 12, Issue 8, 1998, Pages 873-878

  Kazanjian, Powel ^a,d   Locke, Amy B ^b   Hossler, Paul A ^b   Lane, Brian R ^b   Bartlett, Marilyn S ^c   Smith, James W ^c   Cannon, Mark ^a   Meshnick, Steven R ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Dihydropteroate synthase; Pneumocystis carinii pneumonia; Sulfa resistance

Indexed keywords

DIHYDROPTEROATE SYNTHASE; SULFANILAMIDE; SULFONE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; FEMALE; GENE MUTATION; HUMAN; MALE; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TREATMENT FAILURE;

ADOLESCENT; ADULT; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; CHILD; DAPSONE; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE, MICROBIAL; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; MUTATION; PNEUMOCYSTIS; PNEUMONIA, PNEUMOCYSTIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TREATMENT FAILURE; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 0032574888     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199808000-00009     Document Type: Article

References (27)

1. Stansell JD, Huang L: Pneumocystis carinii pneumonia. In The Medical Management of AIDS. Edited by Sande MA, Volberding PA. Philadelphia: WB Saunders Co.; 1996:275-300.
2. Murray JF, Felton CP, Garay SM, et al.: Pulmonary complications of AIDS. N Engl J Med 1484, 310:1682-1688.
3. Centers for Disease Control and Prevention: HIV/AIDS Surveillance Report, No. 5. Atlanta: CDC; 1994.
4. Centers for Disease Control and Prevention: HIV/AIDS Surveillance Report, No. 6. Atlanta: CDC; 1994.
5. Simonds RJ, Hughes WT, Feinberg J, Navin TR: Preventing Pneumocystis carinii pneumonia in persons infected with human immunodeficiency virus. Clin Infect Dis 1995, 21 (suppl 1):S44-S48.
6. Bozzette SA, Finkelstein DM, Spector SA, et al.: A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. N Engl J Med 1995, 332:693-699.
7. Centers for Disease Control: Recommendations for prophylaxis against Pneumocystis carinii pneumonia for adults and adolescents infected with human immunodeficiency virus. MMWR 1992, 41:1-8.
8. Hughes WT, Killmar J: Is trimethoprim of trimethoprimsulfamethoxazole (TMP-SMX) necessary for Pneumocystis carinii pneumonia (PCP) prophylaxis? Fourth Congress on Retroviruses and Opportunitic Infections. Washington, DC, January 1997 [abstract 289].
9. Kunz S, Junker U, Blaser J, et al.: The scid mouse as an experimental model for the evaluation of anti-Pneumocystis carinii therapy. J Antimicrob Chemother 1995, 36:137-155.
10. Walzer PD, Foy J, Steele P, et al.: Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat model of Pneumocystis carinii pneumonia. Antimicroh Agents Chemother 1992, 36:1935-1942.
11. Sammes PG (Ed): Sulfonamides and sulfones. In Comprehensive Medicinal Chemistry Vol 2. Oxford: Pergamon Press; 1990:255-270.
12. Lane BR, Ast JC, Hossler PA, et al.: Dihydropteroate synthase polymorphisms in Pneumocystis carinii. J Infect Dis 1997, 175:482-485.
13. Lee CH, Wang J, Durkin MM, et al.: Amplification of Pneumocystis carinii DNA on specimens scraped from slides. Diagn Microbiol Infect Dis 1994, 18:197-199.
14. Greer CE, Wheeler CM, Manos MM: Sample preparation and PCR amplification from paraffin-embedded tissues. PCR Methods Appl 1994, 3(6):S113-S122.
15. Fermer C, Kristiansen BE, Skold O, Swedberg G: Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origins in other species. J Bacteriol 1995, 177:4669-4675.
16. Lopez P, Espinosa M, Greenberg B, Lacks SA: Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme. J Bacteriol 1987, 169:4120-4126.
17. Brooks DR, Wang P, Read M, et al.: Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfa. Eur J Biochem 1994, 224:397-405.
18. Volpe F, Ballantine S, Delves C: The multifunctional folic acid syntheses fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase, and dihydropteroate synthase. Eur J Biochem 1993, 216:449-458.
19. Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK: Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nature Struct Biol 1997, 4:490-497.
20. Stinger JR: Pneumocystis carinii: what is it exactly? Clin Microbiol Rev 1996, 9:489-498.
21. Beard CB, Navin TR: Molecular epidemiology of Pneumocystis carinii pneumonia, Emerg Infect Dis 1995, 2:147-150.
22. Keely SP, Stringer JR, Baughman RP, et al.: Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. J Infect Dis 1995, 172:595-598.
23. Ioannidis JP, Capelleri JC, Skolnick PR, Lau J, Sacks HS: A metaanalysis of the relative efficacy and toxicity of Pneumocystis carinii prophylacitc regimens. Arch Intern Med 1996, 156:177-188.
24. Saah AJ, Hoover DR, Peng Y, et al.: Predictors for failure of Pneumocystis carinii pneumonia prophylaxis. JAMA 1995, 273:1197-1202.
25. Hughes WT, Killmar JT, Oz HS: Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model. J Infect Dis 1994, 170:906-911.
26. Martin MA, Cox PH, Beck K, et al.: A comparison of the effectiveness of three regimens in the prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients. Arch Intern Med 1992, 152:525-528.
27. Simonds RJ, Hughes WT, Feinberg J, Navin TR: Preventing Pneumocystis carinii pneumonia in persons infected with human immunodeficiency virus. Clin Infect Dis 1995, 21 (suppl 1):S44-S48.