Neocortical synapse density and braak stage in the lewy body variant of Alzheimer disease: A comparison with classic Alzheimer disease and normal aging

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 10, 1998, Pages 955-960

  Brown, Daniel F ^a   Risser, Richard C ^a   Bigio, Eileen H ^a   Tripp, Patrick ^a   Stiegler, Ashley ^a   Welch, Erin ^a   Eagan, Kathleen P ^a   Hladik, Christa L ^a   White III, Charles L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alzheimer disease; Braak staging; Lewy body disease; Synaptophysin

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN SYNAPTOSOME; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; LEWY BODY; MALE; NEOCORTEX; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL;

EID: 0031783985     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199810000-00007     Document Type: Article

References (42)

1. Ditter SM, Mitra SS. Neuropathologic and clinical features of Parkinson's disease in Alzheimer's disease patients. Neurology 1987; 37;754-60
2. Kazee AM, Han LY. Cortical Lewy bodies in Alzheimer's disease. Arch Pathol 1995;119:448-53
3. Lewy FH. Paralysis agitans. In: Lawandowsky M, ed. Handbuch der Neurologie, Berlin: Springer-Verlag, 1912:920-58
4. Lipkin LE. Cytoplasmic inclusions in ganglion cells associated with Parkinsonian states: A neurocellular change studied in 53 cases and 206 control cases. Am J Pathol 1959;35:1117-33
5. Forno LS. Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): Relationship io Parkinsonism. J Am Geriatr Soc 1969;17:557-75
6. Hughes AJ, Daniel SE, Blankson S, Lees AJ. A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 1993;50: 140-48
7. Lippa CF, Smith TW, Swearer JM. Alzheimer's disease and Lewy body disease: A comparative clinicopathological study. Ann Neurol 1994;35:81-88
8. McKeith I, Fairbairn A, Perry R, Thompson P, Perry E. Neuroleptic sensitivity in patients with senile dementia of Lewy body type, BMJ 1992;305:673-78
9. Perry RH, Irving D, Blessed O, Fairbairn A, Perry EK. Senile dementia of Lewy body type: A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci 1990;95:119-39
10. McKeith IG, Perry RH, Fairbairn AF, Jabeen S, Perry EK. Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med 1992;22:911-22
11. Hansen L, Salmon D, Galasko D, et al. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 1990;40:1-8
12. Hansen LA, Masliah E, Galasko D, Terry RD. Plaque-only Alzheimer disease is usually the Lewy body variant, and vice versa. J Neuropathol Exp Neurol 1993;52:648-54
13. Lennox G, Lowe J, Landon M, Byrne EJ, Mayer RJ, Godwin-Austen RB. Diffuse Lewy body disease: Correlative neuropathology using anti-ubiquitin immunocytochemistry. J Neurol Neurosurg Psychiatry 1989;52:1236-47
14. Kosaka K. Diffuse Lewy body disease in Japan. J Neurol 1990; 237:197-204
15. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992;42:631-39
16. Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J. Davis KL, Perl DR Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol 1995;52:81-88
17. Berg L, McKeel D, Miller JP, Baty J, Morris JC, Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 1993;50:349-58
18. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
19. Bancher C, Braak H, Fischer P, Jellinger KA. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci Lett 1993;162:179-82
20. Jellinger K, Braak H, Braak E, Fischer P. Alzheimer lesions in the entorhinal region and isocortex in Parkinson's and Alzheimer's diseases. Ann N Y Acad Sci 1991;640:203-9
21. Braak H, Duyckaerts C, Braak E, Piette F. Neuropathological staging of Alzheimer-related changes correlates with psychometrically assessed intellectual status. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta PF, ed. Alzheimer's Disease: Advances in clinical and basic research. Chichester: Wiley, 1993:131-37
22. Hansen LA, Galasko D, Samuel W, Xia Y, Chen X, Saitoh T. Apolipoprotein-E e-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease. Neurosci Lett 1994;182:63-65
23. Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991;30:572-80
24. DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 1990;27:457-64
25. White CL, III, Tripp P, Eagan KP, Welch E, Stiegler A, Bigio EH. Quantification of synapse density in Alzheimer disease neocortex using a two-site enzyme-linked immunosorbant assay (ELISA) and antibodies to synaptophysin. J Neuropathol Exp Neurol 1995;54:430
26. Wakabayashi K, Honer WG, Masliah E. Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain Res 1994;667:24-32
27. Samuel W, Alford M, Hofstetter CR, Hansen L. Dementia with Lewy bodies versus pure Alzheimer disease: Differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. J Neuropathol Exp Neurol 1997;56:499-508
28. Folstein MF, Folstein SE, McHugh PR, "Mini-Mental State": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98
29. Blessed G, Tomlinson BE, Roth M. The association between quan titative measures of dementia and of senile change in the cerebra gray matter of elderly subjects. Br J Psychiatry 1968;114:797-81
30. Hughes C, Berg L, Danziger W. A new clinical scale for the stagi of dementia. Br J Psychiatry 1982;140:566-72
31. Mirra SS, Hart MN, Terry RD. Making the diagnosis of Alzheimer's disease: A primer for practicing pathologists. Arch Pathol Lab Med 1993;117:132-44
32. Gearing M, Mirra SS. Alzheimer's disease with concomitant Parkinson's disease changes: Two subgroups defined by neurofibrillary pathology. J Neuropathol Exp Neurol 1997;56:616
33. Brown DF, Dababo MA, Bigio EH, Risser RC, Eagan KP, Hladik CL, White CL, III. Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease. J Neuropathol Exp Neurol 1998;57:39-46
34. Perry EK, Irving D, Kerwin JM, et al. Cholinergic transmitter and neurotrophic activities in Lewy body dementia: Similarity to Parkinson's and distinction from Alzheimer disease. Alzheimer Dis Assoc Disord 1993;7:69-79
35. Langlais PJ, Thal L, Hansen L, Galasko D, Alford M, Masliah E. Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies. Neurology 1993;43:1927-34
36. Levy R, Eagger S, Griffiths M, Perry E, Honavar M, Dean A, Lantos P. Lewy bodies and response to tacrine in Alzheimer's disease. Lancet 1994;343:176
37. Forstl H, Burns A, Levy R, Cairns N, Luthert P, Lantos P. Neuropathological correlates of behavioural disturbance in confirmed Alzheimer's disease. Br J Psychiatry 1993;163:364-68
38. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996;47:1113-24
39. Weiner MF, Risser RC, Cullum CM, Honig L, White C, III, Speciale S, Rosenberg RN. Alzheimer's disease and its Lewy body variant: A clinical analysis of postmortem verified cases. Am J Psychiatry 1996;153:1269-73
40. Byrne EJ, Lennox G, Godwin-Austen RB, et al. Diagnostic criteria for dementia associated with cortical Lewy bodies. Dementia 1994; 2:283-84
41. Samuel W, Galasko D, Masliah E, Hansen LA. Neocortical Lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease. J Neuropathol Exp Neurol 1996;55:44-52
42. Nishimura M, Tomimoto H, Suenaga T, et al. Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brain. Brain Res 1994;634:339-44