Interleukin 12 augments the liver-associated immunity and reduces liver metastases

Hepato-Gastroenterology

Volumn 43, Issue 11, 1996, Pages 1196-1202

  Okuno, Kiyotaka ^a   Jinnai, Hiroki ^a   Lee, Yun Sun ^a   Kaneda, Kenji ^b   Yasutomi, Masayuki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Interleukin 12; Liver associated immunity; Liver metastasis

Indexed keywords

CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFICACY; FLOW CYTOMETRY; IMMUNITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER METASTASIS; LIVER SINUSOID; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; INTERLEUKIN-12; LIVER; LIVER NEOPLASMS; LYMPHOCYTES; MALE; RATS; RATS, INBRED F344;

EID: 0029912787     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Okuno K, Hirohata T, Nakamura K, et al: Hepatic arterial infusions of interleukin-2 (IL-2)-based immunochemotherapy in the treatment of unresectable liver metastases from colorectal cancer. Clin Ther 1993; 15: 672-683.
2. Okuno K, Yasutomi M. Locoregional immunochemotherapy in liver carcinoma. -present and future- Hepato-Gastoenterol 1995; 42: 578-586.
3. Trinchieri G, Scott P. The role of interleukin 12 in the immune response, disease and therapy. Immunol Today 1994; 15: 460-463.
4. Inoue Y, Kashima Y, Aizawa K, Hatakeyama K. A new rat colon cancer cell line metastasizes spontaneously: biologic characteristics and chemotherapeutic response. Jpn J Cancer Res 1991; 82: 90-97.
5. Bouwens L, Jacobs R, Remels L, Wisse E. Natural cytotoxicity of rat hepatic natural killer cells and macrophages against a syngeneic colon carcinoma. Cancer immunol Immunother 1989; 27: 137-141.
6. Okuno K, Takagi H, Nakamura T, et al. Treatment for unresectable hepatoma via hepatic arterial infusion of lymphokine-activated killer cells generated from autologus spleen cells. Cancer 1986; 58: 1001-1006.
7. Hashimoto W, Takeda K, Anzai R, et al. Cytotoxic NK1.1 Ag+αβ T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol 1995; 154: 4333-4340.
8. Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993; 178: 1223-1230.
9. Lygidakis NJ, Stringaris K, Kokinis K, Lyberopoulos K, Raptis S. Locoregional chemotherapy versus locoregional combined immuno-chemotherapy for patients with advanced metastatic liver disease of colorectal origin: a prospective randomized study. HepatoGastroenterol 1996; 43: 212-220.
10. Sarmiento UM, Riley JH, Knaack PA, et al. Biologic effects of recombinant human interleukin-12 in squirrel monkeys. Lab Invest 1994; 71: 862-873.