메뉴 건너뛰기




Volumn 40, Issue 6, 1999, Pages 1078-1089

Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin

Author keywords

ApoB; Atorvastatin; Cholesterol synthesis; HepG2 cells; HMG CoA reductase inhibitor; Simvastatin

Indexed keywords

APOLIPOPROTEIN B; ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; SIMVASTATIN; VERY LOW DENSITY LIPOPROTEIN;

EID: 0344759107     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (55)

References (57)
  • 1
    • 0027094799 scopus 로고
    • Apolipoprotein B, the major protein component of triglyceride rich and low density lipoprotein
    • Chan, L. 1992. Apolipoprotein B, the major protein component of triglyceride rich and low density lipoprotein. J. Biol. Chem. 267: 25621-25624.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25621-25624
    • Chan, L.1
  • 2
    • 0016825311 scopus 로고
    • Conversion of very low density lipoprotein to low density lipoprotein: A metabolic study of apolipoprotein B catabolism in man
    • Sigurdsson, G., A. Nicholl, and B. Lewis. 1975. Conversion of very low density lipoprotein to low density lipoprotein: a metabolic study of apolipoprotein B catabolism in man. J. Clin. Invest. 56: 1481-1490.
    • (1975) J. Clin. Invest. , vol.56 , pp. 1481-1490
    • Sigurdsson, G.1    Nicholl, A.2    Lewis, B.3
  • 3
    • 0027504998 scopus 로고
    • Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in HepG2 cells
    • Sakata, N., X. Wu, J. Dixon, and H. N. Ginsberg. 1993. Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in HepG2 cells. J. Biol. Chem. 268: 22967-22970.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22967-22970
    • Sakata, N.1    Wu, X.2    Dixon, J.3    Ginsberg, H.N.4
  • 4
    • 0028170409 scopus 로고
    • Proteolysis-coupled secretion of the N-terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate
    • Du, E. Z., J. Kurth, S. Wang, P. Humiston, and R. A. Davis. 1994. Proteolysis-coupled secretion of the N-terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate. J. Biol. Chem. 269: 24169-24176.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24169-24176
    • Du, E.Z.1    Kurth, J.2    Wang, S.3    Humiston, P.4    Davis, R.A.5
  • 5
    • 0024363393 scopus 로고
    • The apolipoprotein B gene is constitutively expressed in HepG2 cells: Regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life
    • Pullinger, C. R., J. D. North, B. Teng, V. A. Rifici, A. E. Ronhild de Brito, and J. Scott. 1989. The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life. J. Lipid Res. 30: 1065-1077.
    • (1989) J. Lipid Res. , vol.30 , pp. 1065-1077
    • Pullinger, C.R.1    North, J.D.2    Teng, B.3    Rifici, V.A.4    Ronhild De Brito, A.E.5    Scott, J.6
  • 6
    • 0028245065 scopus 로고
    • Exogenous VLDL stimulates apolipoprotein B secretion from HepG2 cells by both pre-and post-translational mechanisms
    • Wu, X., N. Sakata, J. Dixon, and H. N. Ginsberg. 1994. Exogenous VLDL stimulates apolipoprotein B secretion from HepG2 cells by both pre-and post-translational mechanisms. J. Lipid Res. 35: 1200-1210.
    • (1994) J. Lipid Res. , vol.35 , pp. 1200-1210
    • Wu, X.1    Sakata, N.2    Dixon, J.3    Ginsberg, H.N.4
  • 7
    • 0027487995 scopus 로고
    • Rapid stimulation of apolipoprotein B secretion by oleate is not associated with cholesteryl ester biosynthesis in HepG2 cells
    • Furukawa, S., and T. Hirano. 1993. Rapid stimulation of apolipoprotein B secretion by oleate is not associated with cholesteryl ester biosynthesis in HepG2 cells. Biochim. Biophys. Acta. 1170: 32-37.
    • (1993) Biochim. Biophys. Acta. , vol.1170 , pp. 32-37
    • Furukawa, S.1    Hirano, T.2
  • 8
    • 0028365288 scopus 로고
    • Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester
    • Wu, X., N. Sakata, E. Lui, and H. N. Ginsberg. 1994. Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. J. Biol. Chem. 269: 12375-12382.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12375-12382
    • Wu, X.1    Sakata, N.2    Lui, E.3    Ginsberg, H.N.4
  • 9
    • 0029795221 scopus 로고    scopus 로고
    • ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools
    • Benoist, F., and T. Grand-Perret. 1996. ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools. Arterioscler. Thromb. Vasc. Biol. 16: 1229-1235.
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 1229-1235
    • Benoist, F.1    Grand-Perret, T.2
  • 10
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao, Z., and D. E. Vance. 1988. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J. Biol. Chem. 263: 2998-3004.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2998-3004
    • Yao, Z.1    Vance, D.E.2
  • 11
    • 0030059038 scopus 로고    scopus 로고
    • Inhibition of acyl-CoA:Cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells
    • Musanti, R., L. Giorgini, P. Lovisolo, A. Pirillo, A. Chiari, and G. Ghiselli. 1996. Inhibition of acyl-CoA:cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells. J. Lipid Res. 37: 1-14.
    • (1996) J. Lipid Res. , vol.37 , pp. 1-14
    • Musanti, R.1    Giorgini, L.2    Lovisolo, P.3    Pirillo, A.4    Chiari, A.5    Ghiselli, G.6
  • 12
    • 0027160448 scopus 로고
    • Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes
    • Tanaka, M., H. Jingami, H. Otani, M. Cho, Y. Ueda, H. Arai, Y. Nagano, T. Doi, M. Yokode, and T. Kita. 1993. Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes. J. BioL Chem. 268: 12713-12718.
    • (1993) J. Biol Chem. , vol.268 , pp. 12713-12718
    • Tanaka, M.1    Jingami, H.2    Otani, H.3    Cho, M.4    Ueda, Y.5    Arai, H.6    Nagano, Y.7    Doi, T.8    Yokode, M.9    Kita, T.10
  • 13
    • 0025667289 scopus 로고
    • Regulation of apob secretion from HepG2 cells: Evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge
    • Cianflone, K., Z. Yasruel, M. A. Rodriguez, D. Vas, and A. D. Sniderman. 1990. Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. J. Lipid Res. 31: 2045-2055.
    • (1990) J. Lipid Res. , vol.31 , pp. 2045-2055
    • Cianflone, K.1    Yasruel, Z.2    Rodriguez, M.A.3    Vas, D.4    Sniderman, A.D.5
  • 14
    • 0029610830 scopus 로고
    • Role of the neutral lipid accessible pool in the regulation of secretion of apoB-100 lipoprotein particles by HepG2 cells
    • Kohen Avramoglu, R., K. Cianflone, and A. D. Sniderman. 1995. Role of the neutral lipid accessible pool in the regulation of secretion of apoB-100 lipoprotein particles by HepG2 cells. J. Lipid Res. 36: 2513-2528.
    • (1995) J. Lipid Res. , vol.36 , pp. 2513-2528
    • Kohen Avramoglu, R.1    Cianflone, K.2    Sniderman, A.D.3
  • 15
    • 0026631291 scopus 로고
    • Regulation of HMG-CoA reductase, apolipoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in HepG2, human and rat hepatocytes
    • Qin, W., J. Infante, S. Wang, and R. Infante. 1992. Regulation of HMG-CoA reductase, apolipoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in HepG2, human and rat hepatocytes. Biochim. Biophys. Acta. 1127: 57-66.
    • (1992) Biochim. Biophys. Acta. , vol.1127 , pp. 57-66
    • Qin, W.1    Infante, J.2    Wang, S.3    Infante, R.4
  • 16
    • 0026705766 scopus 로고
    • The effect of low density lipoproteins, cholesterol, and 25-hydroxycholesterol on apolipoprotein B gene expression in HepG2 cells
    • Dashti, N. 1992. The effect of low density lipoproteins, cholesterol, and 25-hydroxycholesterol on apolipoprotein B gene expression in HepG2 cells. J. Biol Chem. 267: 7160-7169.
    • (1992) J. Biol Chem. , vol.267 , pp. 7160-7169
    • Dashti, N.1
  • 17
    • 0028889942 scopus 로고
    • ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys
    • Carr, T. P., J. R. L. Hamilton, and L. L. Rudel. 1995. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J. Lipid Res. 36: 25-36.
    • (1995) J. Lipid Res. , vol.36 , pp. 25-36
    • Carr, T.P.1    Hamilton, J.R.L.2    Rudel, L.L.3
  • 18
    • 0027955907 scopus 로고
    • Inhibition of hepatic ACAT decreases apoB secretion in miniature pigs fed a cholesterol-free diet
    • Huff, M. W., D. E. Telford, P. H. Barrett, D. W. Bilheimer, and P. J. Gillies. 1994. Inhibition of hepatic ACAT decreases apoB secretion in miniature pigs fed a cholesterol-free diet. Arterioscler. Thromb. 14: 1498-1508.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 1498-1508
    • Huff, M.W.1    Telford, D.E.2    Barrett, P.H.3    Bilheimer, D.W.4    Gillies, P.J.5
  • 19
    • 0026680805 scopus 로고
    • Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins
    • Arad, Y., R. Ramakrishnan, and H. N. Ginsberg. 1992. Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins. Metabolism. 41: 487-493.
    • (1992) Metabolism. , vol.41 , pp. 487-493
    • Arad, Y.1    Ramakrishnan, R.2    Ginsberg, H.N.3
  • 21
    • 0029098470 scopus 로고
    • Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolemia: Pathophysiological and therapeutic implications
    • Watts, G. F., M. H. Cummings, M. Umpleby, J. R. Quiney, R. Naoumova, G. R. Thompson, and P. H. Sonksen. 1995. Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolemia: pathophysiological and therapeutic implications. Eur. J. Clin. Invest. 25: 559-567.
    • (1995) Eur. J. Clin. Invest. , vol.25 , pp. 559-567
    • Watts, G.F.1    Cummings, M.H.2    Umpleby, M.3    Quiney, J.R.4    Naoumova, R.5    Thompson, G.R.6    Sonksen, P.H.7
  • 22
    • 0030870265 scopus 로고    scopus 로고
    • Inhibition of cholesterogenesis decreases hepatic secretion of apoB-100 in normolipidemic subjects
    • Watts, G. F., R. P. Naoumova, J. M. Kelly, F. M. Riches, K. D. Croft, and G. R. Thompson. 1997. Inhibition of cholesterogenesis decreases hepatic secretion of apoB-100 in normolipidemic subjects. Am. J. Physiol 273: E462-E470.
    • (1997) Am. J. Physiol , vol.273
    • Watts, G.F.1    Naoumova, R.P.2    Kelly, J.M.3    Riches, F.M.4    Croft, K.D.5    Thompson, G.R.6
  • 23
    • 0025162133 scopus 로고
    • The effect of HMG-CoA reductase inhibitor (CS-514) on the synthesis and secretion of apolipoproteins B and A-I in the human hepatoblastoma HepG2
    • Sato, R., T. Imanaka, and T. Takano. 1990. The effect of HMG-CoA reductase inhibitor (CS-514) on the synthesis and secretion of apolipoproteins B and A-I in the human hepatoblastoma HepG2. Biochim. Biophys. Acta. 1042: 36-41.
    • (1990) Biochim. Biophys. Acta. , vol.1042 , pp. 36-41
    • Sato, R.1    Imanaka, T.2    Takano, T.3
  • 24
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47.
    • (1986) Science. , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 25
    • 0000716338 scopus 로고
    • Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes
    • Bilheimer, D. W., S. M. Grundy, M. S. Brown, and J. L. Goldstein. 1983. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc. Natl. Acad. Sci. USA. 80: 4124-4128.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 4124-4128
    • Bilheimer, D.W.1    Grundy, S.M.2    Brown, M.S.3    Goldstein, J.L.4
  • 26
    • 0022230582 scopus 로고
    • Mevinolin and cholestyramine inhibit the direct synthesis of low density lipoprotein apolipoprotein B in miniature pigs
    • Huff, M. W., D. E. Telford, K. Woodcroft, and W. L. P. Strong. 1985. Mevinolin and cholestyramine inhibit the direct synthesis of low density lipoprotein apolipoprotein B in miniature pigs. J. Lipid Res. 26: 1175-1186.
    • (1985) J. Lipid Res. , vol.26 , pp. 1175-1186
    • Huff, M.W.1    Telford, D.E.2    Woodcroft, K.3    Strong, W.L.P.4
  • 27
    • 0001921101 scopus 로고
    • Atorvastatin: A step ahead for HMG-CoA reductase inhibitors
    • X. F. P. Woodward, J. Davignon, and A. Sniderman, editors. Elsevier Science Publishers BV, Amsterdam
    • Black, D. M. 1995. Atorvastatin: a step ahead for HMG-CoA reductase inhibitors. In Atherosclerosis X. F. P. Woodward, J. Davignon, and A. Sniderman, editors. Elsevier Science Publishers BV, Amsterdam. 307-310.
    • (1995) Atherosclerosis , pp. 307-310
    • Black, D.M.1
  • 29
    • 0032032592 scopus 로고    scopus 로고
    • Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
    • Jones, P., S. Kafonek, I. Laurora, and D. Hunninghake. 1998. Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am. J. Cardiol. 81: 582-587.
    • (1998) Am. J. Cardiol. , vol.81 , pp. 582-587
    • Jones, P.1    Kafonek, S.2    Laurora, I.3    Hunninghake, D.4
  • 30
    • 0029113047 scopus 로고
    • Lipid-lowering activity of atorvastatin and lovastatin in rodent species: Triglyceride-lowering in rats correlates with efficacy in LDL animal models
    • Krause, B. R., and R. S. Newton. 1995. Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models. Atherosclerosis. 117: 237-244.
    • (1995) Atherosclerosis , vol.117 , pp. 237-244
    • Krause, B.R.1    Newton, R.S.2
  • 31
    • 0031445149 scopus 로고    scopus 로고
    • Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in mice devoid of low density lipoprotein receptors
    • Bisgaier, C. L., A. D. Essenburg, B. J. Auerbach, M. E. Pape, C. S. Sekerke, A. Gee, S. Wolle, and R. S. Newton. 1997. Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors. J. Lipid Res. 38: 2502-2515.
    • (1997) J. Lipid Res. , vol.38 , pp. 2502-2515
    • Bisgaier, C.L.1    Essenburg, A.D.2    Auerbach, B.J.3    Pape, M.E.4    Sekerke, C.S.5    Gee, A.6    Wolle, S.7    Newton, R.S.8
  • 32
    • 0026700503 scopus 로고
    • Lipolysis is a prerequisite for lipid accumulation in HepG2 cells induced by large hypertriglyceridemic very low density lipoproteins
    • Evans, A. J., C. G. Sawyez, B. M. Wolfe, and M. W. Huff. 1992. Lipolysis is a prerequisite for lipid accumulation in HepG2 cells induced by large hypertriglyceridemic very low density lipoproteins. J. Biol. Chem. 267: 10743-10751.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10743-10751
    • Evans, A.J.1    Sawyez, C.G.2    Wolfe, B.M.3    Huff, M.W.4
  • 33
    • 0027405261 scopus 로고
    • Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts
    • Carr, T. P., C. J. Andresen, and L. L. Rudel. 1993. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin. Biochem. 26: 39-42.
    • (1993) Clin. Biochem. , vol.26 , pp. 39-42
    • Carr, T.P.1    Andresen, C.J.2    Rudel, L.L.3
  • 34
    • 0031899996 scopus 로고    scopus 로고
    • Oxidized type IV hypertriglyceridemic VLDL-remnants cause greater macrophage cholesteryl ester accumulation than oxidized LDL
    • Whitman, S. C., C. G. Sawyez, D. B. Miller, B. M. Wolfe, and M. W. Huff. 1998. Oxidized type IV hypertriglyceridemic VLDL-remnants cause greater macrophage cholesteryl ester accumulation than oxidized LDL. J. Lipid Res. 39: 1008-1020.
    • (1998) J. Lipid Res. , vol.39 , pp. 1008-1020
    • Whitman, S.C.1    Sawyez, C.G.2    Miller, D.B.3    Wolfe, B.M.4    Huff, M.W.5
  • 35
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 36
    • 0028245839 scopus 로고
    • Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells
    • Adeli, K. 1994. Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells. J. Biol. Chem. 269: 9166-9175.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9166-9175
    • Adeli, K.1
  • 37
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 38
    • 0025364953 scopus 로고
    • A solution hybridization/ RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines
    • Azrolan, N., and J. L. Breslow. 1990. A solution hybridization/ RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines. J. Lipid Res. 31: 1141-1146.
    • (1990) J. Lipid Res. , vol.31 , pp. 1141-1146
    • Azrolan, N.1    Breslow, J.L.2
  • 39
    • 0022003749 scopus 로고
    • Effects of estrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2
    • Tam, S., T. K. Archer, and R. G. Deeley. 1985. Effects of estrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2. J. Biol. Chem. 260: 1670-1675.
    • (1985) J. Biol. Chem. , vol.260 , pp. 1670-1675
    • Tam, S.1    Archer, T.K.2    Deeley, R.G.3
  • 40
    • 0031930805 scopus 로고    scopus 로고
    • Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity
    • Ness, G. C., C. M. Chambers, and D. Lopez. 1998. Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity. J. Lipid Res. 39: 75-84.
    • (1998) J. Lipid Res. , vol.39 , pp. 75-84
    • Ness, G.C.1    Chambers, C.M.2    Lopez, D.3
  • 42
    • 0032559306 scopus 로고    scopus 로고
    • Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: A comparison of atorvastatin and simvastatin
    • Bergstrom, J. D., R. G. Bostedor, D. J. Rew, W. M. Geissler, S. D. Wright, and Y. S. Chao. 1998. Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin. Biochim. Biophys. Acta. 1389: 213-221.
    • (1998) Biochim. Biophys. Acta. , vol.1389 , pp. 213-221
    • Bergstrom, J.D.1    Bostedor, R.G.2    Rew, D.J.3    Geissler, W.M.4    Wright, S.D.5    Chao, Y.S.6
  • 43
    • 0031832210 scopus 로고    scopus 로고
    • Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells
    • Mohammadi, A., J. Macri, R. Newton, T. Romain, D. Dulay, and K. Adeli. 1998. Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells. Arterioscler. Thromb. Vasc. Biol. 18: 783-793.
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 783-793
    • Mohammadi, A.1    Macri, J.2    Newton, R.3    Romain, T.4    Dulay, D.5    Adeli, K.6
  • 44
    • 0030454106 scopus 로고    scopus 로고
    • Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig
    • Conde, K., V. Marcela, B. R. Krause, R. S. Newton, and M. L. Fernandez. 1996. Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig. J. Lipid Res. 37: 2372-2382.
    • (1996) J. Lipid Res. , vol.37 , pp. 2372-2382
    • Conde, K.1    Marcela, V.2    Krause, B.R.3    Newton, R.S.4    Fernandez, M.L.5
  • 45
    • 0030581123 scopus 로고    scopus 로고
    • Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells
    • Graham, A., J. L. Wood, and L. J. Russell. 1996. Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. Biochim. Biophys. Acta. 1302: 46-54.
    • (1996) Biochim. Biophys. Acta. , vol.1302 , pp. 46-54
    • Graham, A.1    Wood, J.L.2    Russell, L.J.3
  • 46
    • 0030012624 scopus 로고    scopus 로고
    • Low rates of apoB secretion from HepG2 cells result from reduced delivery of newly synthesized triglyceride to a "secretion-coupled" pool
    • Wu, X., A. Shang, H. Jiang, and H. N. Ginsberg. 1996. Low rates of apoB secretion from HepG2 cells result from reduced delivery of newly synthesized triglyceride to a "secretion-coupled" pool. J. Lipid Res. 37: 1198-1206.
    • (1996) J. Lipid Res. , vol.37 , pp. 1198-1206
    • Wu, X.1    Shang, A.2    Jiang, H.3    Ginsberg, H.N.4
  • 47
    • 0028139446 scopus 로고
    • Lipid balance in HepG2 cells: Active synthesis and impaired mobilization
    • Gibbons, G. F., R. Khurana, A. Odwell, and M. C. L. Seelaender. 1994. Lipid balance in HepG2 cells: active synthesis and impaired mobilization. J. Lipid Res. 35: 1801-1808.
    • (1994) J. Lipid Res. , vol.35 , pp. 1801-1808
    • Gibbons, G.F.1    Khurana, R.2    Odwell, A.3    Seelaender, M.C.L.4
  • 49
    • 0022973332 scopus 로고
    • Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in HepG2 cells
    • Bostrom, K., M. Wettesten, J. Boren, G. Bondjers, O. Wiklund, and S. Olofsson. 1986. Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in HepG2 cells. J. Biol. Chem. 261: 13800-13806.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13800-13806
    • Bostrom, K.1    Wettesten, M.2    Boren, J.3    Bondjers, G.4    Wiklund, O.5    Olofsson, S.6
  • 50
    • 0030906716 scopus 로고    scopus 로고
    • Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells
    • Ginsberg, H. N. 1997. Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells. Clin. Exp. Pharmacol. Physiol. 24: A29-A32.
    • (1997) Clin. Exp. Pharmacol. Physiol. , vol.24
    • Ginsberg, H.N.1
  • 51
    • 10244270656 scopus 로고    scopus 로고
    • Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B
    • Yeung, S. J., S. H. Chen, and L. Chan. 1996. Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B. Biochemistry. 35: 843-848.
    • (1996) Biochemistry. , vol.35 , pp. 843-848
    • Yeung, S.J.1    Chen, S.H.2    Chan, L.3
  • 52
    • 0030860899 scopus 로고    scopus 로고
    • The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
    • Fisher, E. A., M. Zhou, D. M. Mitchell, X. Wu, S. Omura, H. Wang, A. L. Goldberg, and H. N. Ginsberg. 1997. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol. Chem. 272: 20427-20434.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20427-20434
    • Fisher, E.A.1    Zhou, M.2    Mitchell, D.M.3    Wu, X.4    Omura, S.5    Wang, H.6    Goldberg, A.L.7    Ginsberg, H.N.8
  • 54
    • 0030967744 scopus 로고    scopus 로고
    • Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells
    • Adeli, K., J. Macri. A. Mohammadi, M. Kito, R. Urade, and D. Cavallo. 1997. Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells. J. Biol. Chem. 272: 22489-22494.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22489-22494
    • Adeli, K.1    Macri, J.2    Mohammadi, A.3    Kito, M.4    Urade, R.5    Cavallo, D.6
  • 57
    • 0029047046 scopus 로고
    • Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: Insulin negatively regulates MTP gene expression
    • Lin, M. C. M., D. Gordon, and J. R. Wetterau. 1995. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J. Lipid Res. 36: 1073-1081.
    • (1995) J. Lipid Res. , vol.36 , pp. 1073-1081
    • Lin, M.C.M.1    Gordon, D.2    Wetterau, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.