Prolonged exposure to γ-aminobutyric acid up-regulates stably expressed recombinant α1β2γ2s GABAA receptors

European Journal of Pharmacology

Volumn 482, Issue 1-3, 2003, Pages 117-125

  Peričić, Danka ^a   Štrac, Dubravka Švob ^a   Jembrek, Maja Jazvinšćak ^a   Rajčan, Ivana ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Diazepam; GABA ( aminobutyric acid); GABAA receptor; HEK 293 cell; Muscimol; Radioligand binding

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; CYCLOHEXIMIDE; DIAZEPAM; FLUNITRAZEPAM; MUSCIMOL; PROTEIN SYNTHESIS INHIBITOR;

ARTICLE; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; DRUG EXPOSURE; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

EID: 0344737706     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.10.023     Document Type: Article

References (42)

1. A receptors uncouples allosteric binding: studies on possible mechanisms. J. Neurochem. 79:2001;1100-1108.
2. Barnard E.A. The transmitter-gated channels: a range of receptor types and structures. Trends Pharmacol. Sci. 17:1996;305-308.
3. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50:1998;291-313.
4. A receptors. J. Recept. Signal. Transduct. Res. 17:1997;99-113.
5. 1 subunit protein in rat cerebellar granule cells. Br. J. Pharmacol. 118:1996;1103-1110.
6. A/benzodiazepine receptor polypeptides from the surface of chick cortical neurons. J. Biol. Chem. 269:1994;1548-1553.
7. A receptors and benzodiazepines: a role for dendritic resident subunit mRNAs. Neuropharmacology. 43:2002;925-937.
8. A receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK 293 cells. Neuropharmacology. 39:2000;611-620.
9. Friedman L.K., Gibbs T.T., Farb D.H. γ-Aminobutyric acid A receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res. 707:1996;100-109.
10. 3H]flunitrazepam binding in human embryonic kidney cell. Eur. J. Pharmacol. Mol. Pharmacol. 289:1995;87-95.
11. Gallager D.W., Lakoski J.M., Gonsalves S.F., Rauch S.L. Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity. Nature. 308:1984;74-77.
12. Hablitz J.J., Tehrani M.H., Barnes E.M. Jr. Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currents. Brain Res. 501:1989;332-338.
13. A receptor alpha 1-subunit mRNA in primary cultured cerebral cortical neurons. Brain Res. Mol. Brain Res. 15:1992;327-331.
14. Hu X.J., Ticku M.K. Chronic benzodiazepine agonist treatment reduces functional uncoupling of the γ-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons. Mol. Pharmacol. 45:1994;618-625.
15. A receptor mRNAs and increases ligand binding. J. Neurochem. 62:1993;2334-2337.
16. A receptor structure and function by chronic drug treatments in vivo and with stably transfected cells. Jpn. J. Pharmacol. 70:1996;1-15.
17. A receptors expressed in stably transfected cells. J. Neurochem. 63:1994;2349-2352.
18. A and benzodiazepine agonists. J. Pharmacol. Exp. Ther. 274:1995;1484-1492.
19. Korpi E.R., Grunder G., Lüddens H. Drug interactions at GABA (A) receptors. Prog. Neurobiol. 67:2002;113-159.
20. A receptor. J. Neurochem. 60:1993;1972-1975.
21. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
22. A receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. J. Neurochem. 78:2001;1114-1125.
23. Maksay G., Ticku M.K. Pretreatment with GABA and modulatory ligands enhances GABA receptor binding. Eur. J. Pharmacol. 104:1984;185-188.
24. McKernan R.M., Whiting P.J. Which GABA (A)-receptor subtypes really occur in the brain. Trends Neurosci. 19:1996;139-143.
25. McPherson G.A. A practical computer-based approach to the analysis of radioligand binding experiments. Comput. Prog. Biomed. 17:1983;107-114.
26. Mehta A.K., Ticku M.K. Chronic GABA exposure down-regulates GABA-benzodiazepine receptor-ionophore complex in cultured cerebral cortical neurons. Mol. Brain Res. 16:1992;29-36.
27. A receptors. Brain Res. Brain Res. Rev. 29:1999;196-217.
28. Meier E., Dreier J., Schousboe A. Trophic actions of GABA on the development of physiologically active GABA receptors. Adv. Biochem. Psychopharmacol. 37:1983;47-58.
29. A receptor complex in an inhibitory synaptic circuit in the rat cerebellum. Dev. Brain Res. 55:1990;73-86.
30. A receptor alpha 2 and alpha 3 subunit mRNAs as well as polypeptide expression in primary cultured cerebral cortical neurons. Brain Res. Mol. Brain Res. 24:1994;159-165.
31. A receptor alpha subunit messenger RNAs in embryonic chick neurons in culture. J. Biol. Chem. 266:1991;6011-6014.
32. Owens D.F., Kriegstein A.R. Is there more to GABA than synaptic inhibition? Nat. Rev. Neurosci. 3:2002;715-727.
33. A receptor. Eur. J. Pharmacol. 360:1998;99-104.
34. A receptor subunit protein and mRNA expression in rat cultured cerebellar granule cells. Br. J. Pharmacol. 119:1996;1393-1400.
35. A receptors expressed in Sf9 cells: ligand efficacy and subtype selectivity. J. Pharmacol. Exp. Ther. 276:1996;882-890.
36. Roca D.J., Rozenberg I., Farrant M., Farb D.H. Chronic agonist exposure induces down-regulation and allosteric uncoupling of the γ-aminobutyric acid/benzodiazepine receptor complex. Mol. Pharmacol. 37:1990;37-43.
37. A receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol. Pharmacol. 37:1990;710-719.
38. Schousboe A., Redburn D.A. Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. J. Neurosci. Res. 41:1995;1-7.
39. Shaw G., Morse S., Ararat M., Graham F.L. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J. 16:2002;869-871.
40. Sykes C., Prestwich S., Horton R. Chronic administration of the GABA-transaminase inhibitor ethanolamine O-sulphate leads to up-regulation of GABA binding sites. Biochem. Pharmacol. 33:1984;387-393.
41. Tehrani M.H., Barnes E.M.J. GABA down-regulates the GABA/benzodiazepine receptor complex in developing cerebral neurons. Neurosci. Lett. 87:1988;288-292.
42. Wong G., Lyon T., Skolnick P. Chronic exposure to benzodiazepine receptor ligands uncouples the γ-aminobutyric acid type A receptor in WSS-1 cells. Mol. Pharmacol. 46:1994;1056-1062.