Effects of a new immunotherapeutic agent (CG5601) on endotoxin-induced uveitis

Ophthalmic Research

Volumn 35, Issue 3, 2003, Pages 143-149

  Porstmann, Agnes Ute ^a,d   Zwingenberger, K ^b   Pleyer, U ^a   Baatz, H ^c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

CG5601; Endotoxin induced uveitis; Intravital microscopy; Leukocyte endothelium interaction; Thalidomide

Indexed keywords

CG 5601; ENDOTOXIN; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ANTIINFLAMMATORY ACTIVITY; AQUEOUS HUMOR; ARTICLE; CELL INTERACTION; CHRONOLOGY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; EVALUATION; EYE INFLAMMATION; FEMALE; FLUORESCENCE MICROSCOPY; INJECTION; LEUKOCYTE; LEUKOCYTE MIGRATION INHIBITION TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; UVEITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AQUEOUS HUMOR; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENDOTOXINS; FEMALE; IMIDAZOLES; LEUKOCYTE ROLLING; LEUKOCYTES; LIPOPOLYSACCHARIDES; RATS; RATS, WISTAR; SPIRO COMPOUNDS; THALIDOMIDE; THIAZOLES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 0344519760     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070049     Document Type: Article

References (40)

1. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR: Endotoxin-induced uveitis in rats as a model for human disease. Nature 1980;286:611-613.
2. Forrester JV, Worgul BV, Merriam GR Jr: Endotoxin-induced uveitis in the rat. Graefes Arch Klin Exp Ophthalmol 1980;213:221-233.
3. Bhattacherjee P, Williams RN, Eakins KE: An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad. Invest Ophthalmol Vis Sci 1983;24:196-202.
4. Okumura A, Mochizuki M: Endotoxin-induced uveitis in rats: Morphological and biochemical study. Jpn J Ophthalmol 1988;32:457-465.
5. Herbort CP, Chan CC, Nussenblatt RB: Endotoxin-induced uveitis in the rat: A hypothesis for preferential involvement of the anterior uvea. Curr Eye Res 1990;9(suppl):119-124.
6. Baatz H, Pleyer U, Thiel HJ, Hammer C: In vivo study of leukocyte-endothelium interaction in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1995;36:1960-1967.
7. Baatz H, Tönnessen B, Prada J, Pleyer U: Thalidomide inhibits leukocyte-endothelium interaction in endotoxin-induced uveitis. Ophthalmic Res 2001;33:256-263.
8. Lenz W: Thalidomide and congenital abnormalities. Lancet 1962;ii:45-46.
9. McBride WG: Thalidomide and congenital abnormalities. Lancet 1961;ii:1358.
10. Peuckmann V, Fisch M, Bruera E: Potential novel uses of thalidomide: Focus on palliative care. Drugs 2000;60:273-292.
11. Wnendt S, Finkam M, Winter W, Ossig J, Raabe G, Zwingenberger K: Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analogues. Chirality 1996;8:390-396.
12. Schneider J, Wnendt S, Korioth J, Zwingenberg K: Thalidomide inhibits superantigen-induced TNF-α release in mice. 12th European Immunology Meeting, Barcelona, 1994, W55: Immunosuppressive agents, p 509.
13. Geist C, Wöhrmann T, Schneider J, Zwingenberger K: Effects of thalidomide on the local Shwartzman reaction in mice and rabbits. FEMS Immunol Med Microbiol 1995;12:165-174.
14. Zwingenberger K, Wnendt S: Immunomodulation by thalidomide: Systematic review of the literature and of unpublished observations. J Inflamm 1995;46:177-211.
15. Schneider J, Bruckmann W, Zwingenberger K: Extravasation of leukocytes assessed by intravital microscopy: Effect of thalidomide. Inflamm Res 1997;46:392-397.
16. Yang P, de Vos AF, Kijlstra A: Macrophages and MHC class II positive cells in the choroid during endotoxin induced uveitis. Br J Ophthalmol 1997;81:396-401.
17. Kozhich AT, Chan CC, Gery I, Whitcup SM: Recurrent intraocular inflammation in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 2000;41:1823-1826.
18. Ohta K, Wiggert B, Taylor AW, Streilein JW: Effects of experimental ocular inflammation on ocular immune privilege. Invest Ophthalmol Vis Sci 1999;40:2010-2018.
19. Baatz H, Pleyer U, Hammer C, Thiel HJ: Scheinbare Wandscherrate und Leukozyten-Endothel-Interaktion in Irisgefässen bei Endotoxin-induzierter Uveitis. Ophthalmologe 1996;93:749-753.
20. Baatz H, Pleyer U: Modulation of leukocyte-endothelium interaction by nitric oxide synthase inhibitors: Effects on leukocyte adhesion in endotoxin-induced uveitis. Inflamm Res 2001;50:534-543.
21. Baatz H, Puchta J, Reszka R, Pleyer U: Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis. Exp Eye Res 2001;73:101-109.
22. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994;76:301-314.
23. Johnson-Léger C, Aurrand-Lions M, Imhof BA: The parting of the endothelium: Miracle, or simply a junctional affair? J Cell Sci 2000; 113(pt 6):921-933.
24. Worthylake RA, Burridge K: Leukocyte trans-endothelial migration: Orchestrating the underlying molecular machinery. Curr Opin Cell Biol 2001;13:569-577.
25. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA: The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995;128:1243-1253.
26. Suzuma K, Mandai M, Kogishi J, Tojo SJ, Honda Y, Yoshimura N: Role of P-selectin in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1997;38:1610-1618.
27. Miyamoto K, Ogura Y, Hamada M, Nishiwaki H, Hiroshiba N, Tsujikawa A, et al: In vivo neutralization of P-selectin inhibits leukocyte-endothelial interactions in retinal microcirculation during ocular inflammation. Microvasc Res 1998;55:230-240.
28. Suzuma I, Mandai M, Suzuma K, Ishida K, Tojo SJ, Honda Y: Contribution of E-selectin to cellular infiltration during endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1998;39:1620-1630.
29. Whitcup SM, DeBarge LR, Rosen H, Nussenblatt RB, Chan CC: Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1993;34:673-681.
30. Kanagawa T, Matsuda S, Mikawa Y, Kogiso M, Nagasawa H, Himeno K, et al: Role of ICAM-1 and LFA-1q in endotoxin-induced uveitis in mice. Jpn J Ophthalmol 1996;40:174-180.
31. Rosenbaum JT, Boney RS: Efficacy of antibodies to adhesion molecules, CD11a or CD18, in rabbit models of uveitis. Curr Eye Res 1993;12:827-831.
32. Whitcup SM, Hikita N, Shirao M, Miyasaka M, Tamatani T, Mochizuki M, et al: Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis. Exp Eye Res 1995;60:597-601.
33. Planck SR, Han YB, Park JM, O'Rourke L, Gutierrez-Ramos JC, Rosenbaum JT: The effect of genetic deficiency of adhesion molecules on the course of endotoxin-induced uveitis. Curr Eye Res 1998;17:941-946.
34. Becker MD, Garman K, Whitcup SM, Planck SR, Rosenbaum JT: Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 2001;42:2563-2566.
35. Nogueira AC, Neubert R, Helge H, Neubert D: Thalidomide and the immune system. 3. Simultaneous up- and down-regulation of different integrin receptors on human white blood cells. Life Sci 1994;55:77-92.
36. Geitz H, Handt S, Zwingenberger K: Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade. Immunopharmacology 1996;31:213-221.
37. Kasner L, Chan CC, Whitcup SM, Gery I: The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1993;34:2911-2917.
38. De Vos AF, van Haren MAC, Verhagen C, Hoekzema R, Kijstra A: Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci 1994;35:1100-1106.
39. De Vos AF, Van Haren MA, Verhagen C, Hoekzema R, Kijlstra A: Systemic anti-tumor necrosis factor antibody treatment exacerbates endotoxin-induced uveitis in the rat. Exp Eye Res 1995;61:667-675.
40. Rosenbaum JT, Han YB, Park JM, Kennedy M, Planck SR: Tumor necrosis factor-alpha is not essential in endotoxin induced eye inflammation: Studies in cytokine receptor deficient mice. J Rheumatol 1998;25:2408-2416.