Thalidomide inhibits leukocyte-endothelium interaction in endotoxin-induced uveitis

Ophthalmic Research

Volumn 33, Issue 5, 2001, Pages 256-263

  Baatz, Holger ^a   Tönessen, Björn ^b   Prada, Javier ^b   Pleyer, Uwe ^b  

^a GOETHE UNIVERSITY   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Corticosteroids; Endotoxin induced uveitis; Intravital microscopy; Leukocyte endothelium interaction; Thalidomide

Indexed keywords

CELL ADHESION MOLECULE; ENDOTOXIN; METHYLPREDNISOLONE; PREDNISOLONE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AQUEOUS HUMOR; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FLUORESCENCE MICROSCOPY; IRIS BLOOD VESSEL; LEUKOCYTE ADHERENCE; LEUKOCYTE MOTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UVEITIS; VASCULAR ENDOTHELIUM;

ANIMALS; CELL ADHESION; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE AGENTS; IRIS; LEUKOCYTE COUNT; LEUKOCYTES; LIPOPOLYSACCHARIDES; MICROSCOPY, FLUORESCENCE; PREDNISOLONE; RATS; RATS, INBRED LEW; SALMONELLA TYPHIMURIUM; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS, ANTERIOR;

EID: 0035742412     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055678     Document Type: Article

References (55)

1. Thalidomide in the treatment of lepra reactions
2. Acute and chronic graft-versus-host disease
3. Treatment of Behçet's disease with thalidomide
4. Thalidomide as treatment of refractory aphthous ulceration related to human immunodeficiency virus infection
5. Thalidomide use in dermatology
6. Thalidomide as replacement for steroids in immunosuppression after lung transplantation
7. Immunomodulation by thalidomide: Systemic review of the literature and of unpublished observations
8. Thalidomide is an inhibitor of angiogenesis
9. Failure of thalidomide to inhibit tumor growth and angiogenesis in vivo
10. Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide
11. Iridocyclitis in lepra reaction treated with thalidomide
12. The effect of thalidomide and supidimide on endotoxin-induced uveitis in rats
13. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
14. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
15. Thalidomide can be either agonistic or antagonistic to LPS evoked synthesis of TNF-alpha by mononuclear cells
16. (S)-Form of alpha-methyl-N(alpha)-phthalimido-glutarimide, but not its (R)-form, enhanced phorbol ester-induced tumor necrosis factor-alpha production by human leukemia cell HL-60: Implication of optical resolution of thalidomidal effects
17. Enhancement of phorbol ester-induced production of tumor necrosis factor alpha by thalidomide
18. Thalidomide derivatives and the immune system. I. Changes in the pattern of integrin receptors and other surface markers on T lymphocyte subpopulations of marmoset blood
19. Thalidomide and the immune system. 2. Changes in receptors on blood cells of a healthy volunteer
20. In vivo study of leukocyte-endothelium interaction in endotoxin-induced uveitis
21. Kinetics of white blood cell staining by intravascular administration of rhodamine 6G
22. Production of hybridoma growth factor by human monocytes
23. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
24. T cell growth factor: Parameters of production and a quantitative microassay for activity
25. Endotoxin-induced uveitis in rats as a model for human disease
26. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat
27. Analysis of interleukin-6 in endotoxin-induced uveitis
28. Endotoxin-induced uveitis in the rat: The significance of intraocular interleukin-6
29. Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin induced uveitis
30. Endotoxin-induced uveitis (EIU) in the rat: A study of inflammatory and immunological mechanisms
31. The role of nitric oxide synthase in endotoxin-induced uveitis: Effects of NG-nitro L-arginine
32. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production
33. Endotoxin-induced uveitis in the rat: Observations on altered vascular permeability, clinical findings, and histology
34. Thalidomide inhibits TNF response and increases survival following endotoxin injection in rats
35. Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency
36. Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice
37. Thalidomide inhibits tumor necrosis factor alpha, decreases nitric oxide synthesis, and ameliorates the hyperdynamic circulatory syndrome in portal-hypertensive rats
38. Thalidomide inhibits tumor necrosis factor-alpha production by lipopolysaccharide- and lipoarabinomannan-stimulated human microglial cells
39. Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analogues
40. Thalidomide may impede cell migration in primates by down-regulating integrin beta-chains: Potential therapeutic utility in solid malignancies, proliferative retinopathy, inflammatory disorders, neointimal hyperplasia, and osteoporosis
41. Extravasation of leukocytes assessed by intravital microscopy: Effect of thalidomide
42. An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane
43. The microcirculation and inflammation: Modulation of leukocyte-endothelial cell adhesion
44. Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis
45. Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis
46. Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis
47. Thalidomide and the immune system. 3. Simultaneous up- and down-regulation of different integrin receptors on human white blood cells
48. Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade
49. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
50. Sulfated polysaccharides inhibit leukocyte rolling in rabbit mesentery venules
51. Inhibition of leukocyte rolling in venules by protamine and sulfated polysaccharides
52. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1
53. The effects of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules
54. Regulation of L-selectin and CD18 on bovine neutrophils by glucocorticoids: Effects of cortisol and dexamethasone