Macrophages and MHC class II positive cells in the choroid during endotoxin induced uveitis

British Journal of Ophthalmology

Volumn 81, Issue 5, 1997, Pages 396-401

  Yang, Peizeng ^a,b   De Vos, Alex F ^a   Kijlstra, Aize ^a,c  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL INFILTRATION; CELL STRUCTURE; CHOROID; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; SCLERA; UVEITIS;

EID: 0030965823     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.81.5.396     Document Type: Article

References (14)

1. Gery I, Streilein JW. Autoimmunity in the eye and its regulation. Curr Opin Immunol 1994;6:938-45.
2. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxin-induced uveitis in rats as a model for human disease. Nature 19980;266:611-3.
3. Yang P, De Vos AF, Kijlstra A. Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide. Invest Ophthalmol Vis Sci 1996;37:77-85.
4. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage populations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985;54:589-99.
5. Forrester JV, McMenamin PG, Holthouse I, Lumsden L, Liversidge J. Localization and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: implication for induction of autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1994;35:64-77.
6. McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse and human eye. Invest Ophthalmol Vis Sci 1994;35:3234-50.
7. Okumura A, Mochizuki M. Endotoxin-induced uveitis in rats: morphological and biochemical study. Jpn J Ophthalmol 1988;32:457-65.
8. Ruiz-Moreno JM, Thillaye B, De Kozak Y. Retino-choroidal changes in endotoxin-induced uveitis in the rat. Ophthalmic Res 1992;24:162-8.
9. McMenamin PG, Crewe J. Endotoxin-induced uveitis: kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci 1995;36:1949-59.
10. Choudhury A, Pakalnis VA, Bowers WE. Characterization and functional activity of dendritic cells from rat choroid. Exp Eye Res 1994;59:297-304.
11. BenEzra D, Forrester JV. Fundal white dots: the spectrum of a similar pathological process. Br J Ophthalmol 1995;79: 856-60.
12. Holt PG, Schon-Hegrad MA, Oliver J. MHC class II antigen-bearing dendritic cells in the pulmonary tissues of the rat; regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 1988; 167:262-74.
13. Holt PG, Degebrodt A, O'Leary C, Krska K, Plozza T. T cell activation by antigen presenting cells from lung tissue digests: suppression by endogenous macrophages. Clin Exp Immunol 1985;62:586-93.
14. De Vos AF, Klaren VNA, Kijlstra A. Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci 1994;35:3873-83.