In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection

Pharmaceutical Research

Volumn 20, Issue 11, 2003, Pages 1820-1826

  Liu, Hanlan ^a   Sabus, Chantel ^b   Carter, Guy T ^b   Du, Chao ^c   Avdeef, Alex ^c   Tischler, Mark ^b  

^a Pharmaceutics Department   (United States)

^b WYETH RESEARCH   (United States)

^c PION INC   (United States)

Author keywords

Liquid chromatography mass spectrometry (LC MS); Parallel artificial membrane permeability assay (PAMPA); Permeability; Solubility; Solubilizer

Indexed keywords

ALCOHOL; ALLOPURINOL; AMOXICILLIN; ATENOLOL; AZITHROMYCIN; BENDROFLUMETHIAZIDE; BENZTHIAZIDE; CARBAMAZEPINE; CIMETIDINE; CREMOPHOR; ERGONIVINE MALEATE; ERYTHROMYCIN; GUANABENZ; IMIPRAMINE; KETOPROFEN; LISINOPRIL; METOPROLOL; MICONAZOLE; OXYPHENBUTAZONE; PHENAZOPYRIDINE; PIROXICAM; POLIDOCANOL; POLYSORBATE 80; PROBENECID; PROMETHAZINE; PROPRANOLOL DERIVATIVE; SOLUBILIZER; TERBUTALINE; TERFENADINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; CHROMATOPHORE; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG PENETRATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PRIORITY JOURNAL; RELIABILITY; TECHNIQUE; ULTRAVIOLET SPECTROSCOPY;

GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MEMBRANES, ARTIFICIAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; WATER;

EID: 0344515259     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000003380.44755.5a     Document Type: Article

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