Chapter 26. Discovery and Identification of Lead Compounds from Combinatorial Mixtures

Annual Reports in Medicinal Chemistry

Volumn 32, Issue C, 1997, Pages 261-268

  Beutel, Bruce A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0344479057     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-7743(08)61484-0     Document Type: Article

References (43)

1. Fenniri H. Cur. Med. Chem. 3 (1996) 343
2. Willard X., Pop I., Bourel L., Baudelle R., Melnyk P., Deprez B., and Tartar A. Eur. J. Med. Chem. 31 (1996) 87
3. Furka A. Drug Dev. Res. 36 (1995) 1
4. Ecker D.J., and Crooke S.T. Biotechnology 13 (1995) 351
5. Geysen H.M., Rodda S.J., and Mason T.J. Mol. Immunol. 23 (1986) 709
6. Oliphant A.R., and Struhl K. Nucl. Acids Res. 16 (1988) 7673
7. Furka A., Sebestyen F., Asgedom M., and Dibo G. In. Abstr. 14th Int. Congr. Biochem. Prague, Czechoslovakia 5 (1988) 47
8. Furka A., Sebestyen F., Asgedom M., and Dibo G. Int. J. Protein Res 37 (1991) 487
9. Houghten R.A. Gene 137 (1993) 7
10. Burbaum J.J., Ohlmeyer M.H.J., Reader J.C., Henderson I., Dillard L.W., Li G., Randle T.L., Sigal N.H., Chelsky D., and Baldwin J.J. Proc. Natl. Acad. Sci. USA 92 (1995) 6027
11. Boutin J.A., and Fauchere A.L. Trends in Pharm. Sci. 17 (1995) 8
12. Chabala J.C. Cur. Opin. Biotech. 6 (1995) 632
13. Jayawickreme C.K., Graminski G.F., Quillan J.M., and Lerner M.R. Proc. Natl. Acad. Sci. USA 91 (1994) 1614
14. Quillan J.M., Jayawickreme C.K., and Lerner M.R. Proc. Natl. Acad. Sci. USA 92 (1995) 2894
15. Salmon S.E., Liu-Stevens R.H., Zhao Y., Lebl M., Krchnak V., Wertman K., Sepetov N., and Lam K.S. Mol. Divers. 2 (1996) 57
16. Z. Yuan, "High Density Assay Formats for Screening Large Combinatorial Chemical Libraries", Society for Biomolecular Screening 2nd Annual Conference, Basel, Switzerland, Oct. 14-17(1996)
17. N. H. Sigal, "New Screening Paradigms for the Evaluation of Small Molecule Combinatorial Libraries", Second Annual High Throughput Screening for Drug Discovery Conference, San Diego, CA, June 14-16(1995)
18. Bock L.C., Griffin L.C., Latham J.A., Vermaas E.H., and Toole J.J. Nature 355 (1992) 564
19. Tuerk C., Macdougal S., and Gold L. Proc. Natl. Acad. Sci. USA 89 (1992) 6988
20. Ellington A.D., and Szostak J.W. Nature 346 (1990) 818
21. Zuckermann R.N., Kerr J.M., Saini M.A., Banville S.C., and Santi D.V. Proc. Natl. Acad. Sci. USA 89 (1992) 4505
22. B. A. Beutel, PCT patent WO95/27072(1995)
23. B. A. Beutel, "COMPILE: A Combinatorial Procedure for Indirect Ligand Eluciation", Expoiting Molecular Diversity: Small Molecule Libraries For Drug Discovery, Cambridge Healthtech Institute Conference, La Jolla, CA Jan. 26-27(1995).
24. Evans D.M., Williams K.P., McGuinnes B., Tarr G., Regnier F., Afeyan N., and Jindal S. Nature Biotech. 14 (1996) 504
25. Fathi R., Rudolph M.J., Gentles R.G., Patel R., MacMillan E.W., Reitman M.S., Pelham D., and Cook A.F. J. Org. Chem. 61 (1996) 5600
26. Cheng X., Chen R., Bruce J.E., Schwartz B.L., Anderson G.A., Hofstadler S.A., Gale D.C., Smith R.D., Gao J., Sigal G.B., Mammen M., and Whitesides G.M. J. Am. Chem. Soc. 117 (1995) 8859
27. Konings D.A.M., Wyatt J.R., Ecker D.J., and Freier S.M. J. Med Chem. 39 (1996) 2710
28. Wilson-Lingardo L., Davis P.W., Ecker D.J., Hebert N., Acevedo O., Sprankle K., Brennan T., Schwarcz L., Freier S.M., and Wyatt J.R. J. Med. Chem. 39 (1996) 2720
29. Dooley C.T., Chung N.N., Wilkes B.C., Schiller P.W., Bidlack J.M., Pasternak G.W., and Houghten R.A. Science 266 (1994) 2019
30. Loo J.A., and DeJohn D.E. Annual Rep. In Med. Chem. 31 (1996) 319
31. Krchnak V., and Lebl M. Mol. Divers. 1 (1995) 193
32. Brummel C.L., Vickerman J.C., Carr S.A., Hemling M.E., Roberts G.D., Johnson W., Weinstock J., Gaitanopoulos D., Benkovic S.J., and Winograd N. Anal. Chem. 68 (1996) 237
33. Haskins N.J., Hunter D.J., Organ A.J., Rahman S.S., and Thom C. Rapid Commun. Mass Sp. 9 (1995) 1437
34. Sarkar S.K., Garigipati R.S., Adams J.L., and Keifer P.A. J. Am. Chem. Soc. 118 (1996) 2305
35. Yan B., Fell J.B., and Kumaravel G. J. Org. Chem. 61 (1996) 7467
36. Brenner S., and Lerner R.A. Proc. Natl. Acad. Sci. USA 89 (1992) 5381
37. Needels M.C., Jones D.G., Tate E.H., Heinkel G.L., Kochersperger L.M., Dower W.J., Barrett R.W., and Gallop M.A. Proc. Natl. Acad. Sci. USA. 90 (1993) 10700
38. Kerr J.M., Banville S.C., and Zuckermann R.N. J. Am. Chem. Soc. 115 (1993) 2529
39. Vagner J., Barany G., Lam K.S., Krchnak V., Sepetov N.F., Ostrem J.A., Strop P., and Lebl M. Proc. Natl. Acad. Sci. USA 93 (1996) 8194
40. Ohlmeyer M.H.J., Swanson R.N., Dillard L.W., Reader J.C., Asouline G., Kobayashi R., Wigler M., and Still W.C. Proc. Natl. Acad. Sci. USA 90 (1993) 10922
41. Burbaum J.J., Ohlmeyer M.H.J., Reader J.C., Henderson I., Dillard L.W., Li G., Randle T.L., Sigal N.H., Chelsky D., and Baldwin J.J. Proc. Natl. Acad. Sci. USA 92 (1995) 6027
42. Ni Z.-J., Maclean D., Holmes C.P., and Gallop M.A. Methods in Enzymol. 267 (1996) 261
43. Ni Z.-J., Maclean D., Holmes C.P., Murphy M.M., Ruhland B., Jacobs J.W., Gordon E.M., and Gallop M.A. J. Med. Chem. 39 (1996) 1601