메뉴 건너뛰기




Volumn 9, Issue 31, 2003, Pages 2553-2565

Novel inhibitors of HIV integrase: The discovery of potential anti-HIV therapeutic agents

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 3' AZIDO 3' DEOXYTHYMIDINE DIPHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDINE MONOPHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDINE TRIPHOSPHATE; AMINOACRIDINE; ANTIRETROVIRUS AGENT; CAMPTOTHECIN; CHLOROQUINE; DIHYDROXYNAPHTHOQUINONE; DINUCLEOTIDE; DINUCLEOTIDE 5' PHOSPHATE; DOXORUBICIN; ELLIPTICINE; ETHIDIUM BROMIDE; HETEROCYCLIC COMPOUND; INTEGRASE; INTEGRASE INHIBITOR; INTERCALATING AGENT; MITOXANTRONE; NATURAL PRODUCT; NUCLEOTIDE; NUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE; OXOACID; PRIMAQUINE; SULFONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS DNA; VIRUS ENZYME; ZIDOVUDINE;

EID: 0344276472     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033453703     Document Type: Review
Times cited : (25)

References (57)
  • 2
    • 0027692154 scopus 로고
    • Multifactorial nature of human immunodeficiency viral disease: Implications for therapy
    • Fauci AS. Multifactorial nature of human immunodeficiency viral disease: Implications for therapy. Science 1993; 262: 1011-1018.
    • (1993) Science , vol.262 , pp. 1011-1018
    • Fauci, A.S.1
  • 3
    • 0004275201 scopus 로고    scopus 로고
    • Lippincott-Raven: Philadelphia PA
    • Luciw PA. In "Fundamental Virology," Lippincott-Raven: Philadelphia PA, 1996; pp. 845-916.
    • (1996) "Fundamental Virology" , pp. 845-916
    • Luciw, P.A.1
  • 4
    • 0023852121 scopus 로고
    • The human immunodeficiency virus: Infectivity and mechanisms of Pathogenesis
    • Fauci AS. The human immunodeficiency virus: Infectivity and mechanisms of Pathogenesis. Science 1988; 239: 617-622.
    • (1988) Science , vol.239 , pp. 617-622
    • Fauci, A.S.1
  • 6
    • 0029011730 scopus 로고
    • Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections
    • De Clercq E. Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. J Med Chem 1995; 38: 2491-2517.
    • (1995) J. Med. Chem. , vol.38 , pp. 2491-2517
    • De Clercq, E.1
  • 7
    • 0028941196 scopus 로고
    • Antiviral therapy of human immunodeficiency virus infections
    • De Clercq E. Antiviral therapy of human immunodeficiency virus infections. Clin Microbiol Rev 1995; 8: 200-239.
    • (1995) Clin. Microbiol. Rev. , vol.8 , pp. 200-239
    • De Clercq, E.1
  • 9
    • 0033630647 scopus 로고    scopus 로고
    • Advances in HIV/AIDS therapy
    • Schrier RW, Baxter JD, Dzau VJ, Fauci AS, eds. Mosby: St. Louis
    • Johnson SC, Gerber JG. Advances in HIV/AIDS therapy. In "Advances in Internal Medicine," Volume 44. Schrier RW, Baxter JD, Dzau VJ, Fauci AS, eds. Mosby: St. Louis 2000; pp. 1-40.
    • (2000) "Advances in Internal Medicine" , vol.44 , pp. 1-40
    • Johnson, S.C.1    Gerber, J.G.2
  • 10
    • 0030708683 scopus 로고    scopus 로고
    • In search of a selective antiviral chemotherapy
    • DeClercq E. In search of a selective antiviral chemotherapy. Clin Microbiol Rev 1997; 10: 674-693.
    • (1997) Clin. Microbiol. Rev. , vol.10 , pp. 674-693
    • DeClercq, E.1
  • 11
    • 0032601403 scopus 로고    scopus 로고
    • HIV-1 integrase: Structural organization, conformational changes, and catalysis
    • Asante-Appiah E, Skalka AM. HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv Virus Res 1999; 52: 351-369.
    • (1999) Adv. Virus Res. , vol.52 , pp. 351-369
    • Asante-Appiah, E.1    Skalka, A.M.2
  • 12
    • 0032601402 scopus 로고    scopus 로고
    • HIV integrase structure and function
    • Esposito D, Craigie R. HIV integrase structure and function. Adv Virus Res 1999; 52: 319-333.
    • (1999) Adv. Virus Res. , vol.52 , pp. 319-333
    • Esposito, D.1    Craigie, R.2
  • 13
    • 0033551443 scopus 로고    scopus 로고
    • The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity
    • Greenwald J, Le V, Butler SL, Bushman FD, Choe S. The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry 1999; 38: 8892-8898.
    • (1999) Biochemistry , vol.38 , pp. 8892-8898
    • Greenwald, J.1    Le, V.2    Butler, S.L.3    Bushman, F.D.4    Choe, S.5
  • 14
    • 0032723359 scopus 로고    scopus 로고
    • Integrating DNA: Transposases and retroviral integrases
    • Haren L, Ton-Hoang B, Chandler M. Integrating DNA: transposases and retroviral integrases. Annu Rev Microbiol 1999; 53: 245-281.
    • (1999) Annu. Rev. Microbiol. , vol.53 , pp. 245-281
    • Haren, L.1    Ton-Hoang, B.2    Chandler, M.3
  • 15
    • 0028034050 scopus 로고
    • Characterization of the minimal DNA- binding domain of the HIV integrase protein
    • Lutzke RAP, Vink C, Plasterk RHA. Characterization of the minimal DNA- binding domain of the HIV integrase protein. Nucleic Acids Res 1994; 22: 4125-4131.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4125-4131
    • Lutzke, R.A.P.1    Vink, C.2    Plasterk, R.H.A.3
  • 17
    • 0029017919 scopus 로고
    • Catalytic domain of HIV-1 integrase: Identification of a soluble mutant by systematic replacement of hydrophobic residues
    • Jenkins TM, Hickman AB, Dyda F, Ghirlando R, Davies DR, Craigie R. Catalytic domain of HIV-1 integrase: Identification of a soluble mutant by systematic replacement of hydrophobic residues. Proc Natl Acad Sci USA 1995; 92: 6057-6061.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6057-6061
    • Jenkins, T.M.1    Hickman, A.B.2    Dyda, F.3    Ghirlando, R.4    Davies, D.R.5    Craigie, R.6
  • 18
    • 0027470432 scopus 로고
    • Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro
    • Leavitt AD, Shiue L, Varmus HE. Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J Biol Chem 1993; 268: 2113-2119.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2113-2119
    • Leavitt, A.D.1    Shiue, L.2    Varmus, H.E.3
  • 19
    • 0026655897 scopus 로고
    • Structural implication of spectroscopic characterization of putative zinc finger peptide from HIV-1 integrase
    • Burke CJ, Sanyal G, Bruner MW, Ryan JA, LaFemina RL, Robbin HL, et al. Structural implication of spectroscopic characterization of putative zinc finger peptide from HIV-1 integrase. J Biol Chem 1992; 267: 9639-9644.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9639-9644
    • Burke, C.J.1    Sanyal, G.2    Bruner, M.W.3    Ryan, J.A.4    LaFemina, R.L.5    Robbin, H.L.6
  • 20
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
    • Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 1994; 266: 1981-1986.
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1    Hickman, A.B.2    Jenkins, T.M.3    Engelman, A.4    Craigie, R.5    Davies, D.R.6
  • 21
    • 0028820595 scopus 로고
    • Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type I integrase
    • Mazumder A, Gazit A, Levitzki A, Nicklaus M, Yung J, Kohlhagen G, et al. Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type I integrase. Biochemistry 1995; 34: 15111-15122.
    • (1995) Biochemistry , vol.34 , pp. 15111-15122
    • Mazumder, A.1    Gazit, A.2    Levitzki, A.3    Nicklaus, M.4    Yung, J.5    Kohlhagen, G.6
  • 22
    • 0028242724 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymidylate
    • Mazumder A, Cooney D, Agbaria R, Gupta M, Pommier Y. Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymidylate. Proc Natl Acad Sci USA 1994; 91: 5771-5775.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5771-5775
    • Mazumder, A.1    Cooney, D.2    Agbaria, R.3    Gupta, M.4    Pommier, Y.5
  • 24
    • 0026660178 scopus 로고
    • Isodideoxynucleosides: A conceptually new class of nucleoside antiviral agents
    • Nair V, Nuesca ZM. Isodideoxynucleosides: A conceptually new class of nucleoside antiviral agents. J Am Chem Soc 1992; 114: 7951-7953.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 7951-7953
    • Nair, V.1    Nuesca, Z.M.2
  • 25
    • 0028989769 scopus 로고
    • Antiviral activity of isomeric dideoxynucleosides of D- and L- related stereochemistry
    • Nair V, Jahnke TS. Antiviral activity of isomeric dideoxynucleosides of D- and L- related stereochemistry. Antimicrob Agents Chemother 1995; 39: 1017-1029.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1017-1029
    • Nair, V.1    Jahnke, T.S.2
  • 26
    • 0029114656 scopus 로고
    • Antiviral, metabolic and pharmacokinetic studies on the isomeric dideoxynucleoside, 4(S)-(6-amino-9H-purin-9-tetrahydro-2(S)- furanmethanol
    • Nair V, St. Clair M, Reardon JE, Krasny HC, Hazen RJ, Paff MT, et al. Antiviral, metabolic and pharmacokinetic studies on the isomeric dideoxynucleoside, 4(S)-(6-amino-9H-purin-9-tetrahydro-2(S)- furanmethanol. Antimicrob Agents Chemother 1995; 39: 1993-1999.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1993-1999
    • Nair, V.1    St. Clair, M.2    Reardon, J.E.3    Krasny, H.C.4    Hazen, R.J.5    Paff, M.T.6
  • 27
    • 0032555101 scopus 로고    scopus 로고
    • Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases
    • Zhang J, Neamati N, Pommier Y, Nair V. Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases. Bioorg Med Chem Lett 1998; 8: 1887-1890.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 1887-1890
    • Zhang, J.1    Neamati, N.2    Pommier, Y.3    Nair, V.4
  • 28
    • 0028824505 scopus 로고
    • T30177, An oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type I
    • Ojwang JO, Buckheit RW, Pommier Y, Mazumder A, De Vreese K, Este JA, et al. T30177, An oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type I. Antimicrob Agents Chemother 1995; 39: 2426-2435.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2426-2435
    • Ojwang, J.O.1    Buckheit, R.W.2    Pommier, Y.3    Mazumder, A.4    De Vreese, K.5    Este, J.A.6
  • 30
    • 0028288222 scopus 로고
    • Triplex helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence
    • Mouscadet J-F, Ketterle C, Carteau S, Goulaouic H, Subra F, Le Bret M, et al. Triplex helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence. Biochemistry 1994; 33: 4187-4196.
    • (1994) Biochemistry , vol.33 , pp. 4187-4196
    • Mouscadet, J.-F.1    Ketterle, C.2    Carteau, S.3    Goulaouic, H.4    Subra, F.5    Le Bret, M.6
  • 31
    • 0029964978 scopus 로고    scopus 로고
    • Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures
    • Mazumder A, Neamati N, Ojwang JO, Sunder S, Rando RF, Pommier Y. Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures. Biochemistry 1996; 35: 13762-13771.
    • (1996) Biochemistry , vol.35 , pp. 13762-13771
    • Mazumder, A.1    Neamati, N.2    Ojwang, J.O.3    Sunder, S.4    Rando, R.F.5    Pommier, Y.6
  • 32
    • 0030902155 scopus 로고    scopus 로고
    • Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides
    • Mazumder A, Uchida H, Neamati N, Sunder S, Jaworska-Maslanka M, Wickstrom E, et al. Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides. Mol Pharmacol 1997; 51: 567-575.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 567-575
    • Mazumder, A.1    Uchida, H.2    Neamati, N.3    Sunder, S.4    Jaworska-Maslanka, M.5    Wickstrom, E.6
  • 35
    • 0035806221 scopus 로고    scopus 로고
    • Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV Integrase
    • Taktakishvili M, Neamati N, Pommier Y, Nair V. Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV Integrase. Bioorg Med Chem Lett 2001; 11: 1433-1435.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1433-1435
    • Taktakishvili, M.1    Neamati, N.2    Pommier, Y.3    Nair, V.4
  • 38
    • 0028818369 scopus 로고
    • 2′-Deoxyadenylyl-(3′→5′)-isodideoxyadenosine. A unique dinucleotide: Synthesis and characterization
    • Jahnke TS, Nair V. 2′-Deoxyadenylyl-(3′→5′)-isodideoxyadenosine. A unique dinucleotide: synthesis and characterization. Bioorg Med Chem Lett 1995; 5: 2235-2238.
    • (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 2235-2238
    • Jahnke, T.S.1    Nair, V.2
  • 39
    • 0031444231 scopus 로고    scopus 로고
    • Novel oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: Solid phase synthesis, enzymology, and CD studies
    • Wenzel T, Nair V. Novel oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: Solid phase synthesis, enzymology, and CD studies. Bioorg Med Chem Lett 1997; 7: 3195-3198.
    • (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 3195-3198
    • Wenzel, T.1    Nair, V.2
  • 40
    • 0032213126 scopus 로고    scopus 로고
    • Self-complimentary oligodeoxyribonucleotides incorporating L-related isodideoxynucleosides: Synthesis, physical characterization, enzymology, and CD studies
    • Wenzel T, Nair V. Self-complimentary oligodeoxyribonucleotides incorporating L-related isodideoxynucleosides: Synthesis, physical characterization, enzymology, and CD studies. Bioconjugate Chemistry 1998; 9: 683-690.
    • (1998) Bioconjugate Chemistry , vol.9 , pp. 683-690
    • Wenzel, T.1    Nair, V.2
  • 41
    • 0034601629 scopus 로고    scopus 로고
    • A new method for the phosphorylation of nucleosides
    • Taktakishvili M, Nair V. A new method for the phosphorylation of nucleosides. Tetrahedron Lett. 2000; 41: 7173-7176.
    • (2000) Tetrahedron Lett. , vol.41 , pp. 7173-7176
    • Taktakishvili, M.1    Nair, V.2
  • 42
    • 0028239062 scopus 로고
    • A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro
    • Ellison V, Brown PO. A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro. Proc Natl Acad Sci USA 1994; 91: 7316-7320.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7316-7320
    • Ellison, V.1    Brown, P.O.2
  • 43
    • 0027474318 scopus 로고
    • Phosphorodithioate DNA as a potential therapeutic drug
    • Marshall WS, Caruthers MH. Phosphorodithioate DNA as a potential therapeutic drug. Science 1993; 259: 1564-1570.
    • (1993) Science , vol.259 , pp. 1564-1570
    • Marshall, W.S.1    Caruthers, M.H.2
  • 44
    • 0020519542 scopus 로고
    • Assay of 2,′5′-oligoadenylate phosphodiesterase activity in mouse L-cell extracts
    • Torrence PF, Imai J, Johnston MI. Assay of 2,′5′-oligoadenylate phosphodiesterase activity in mouse L-cell extracts. Anal Biochem 1993; 129: 103-110.
    • (1993) Anal. Biochem. , vol.129 , pp. 103-110
    • Torrence, P.F.1    Imai, J.2    Johnston, M.I.3
  • 45
    • 0025108129 scopus 로고
    • Dinucleoside phosphates containing arabinose or deoxyxylose. Hydrolysis by exonuclease and stacking properties
    • Sokolova NI, Dolinnaya NG, Krynetskaya NF, Shabarova ZA. Dinucleoside phosphates containing arabinose or deoxyxylose. Hydrolysis by exonuclease and stacking properties. Nucleosides & Nucleotides 1990; 9: 515-531.
    • (1990) Nucleosides & Nucleotides , vol.9 , pp. 515-531
    • Sokolova, N.I.1    Dolinnaya, N.G.2    Krynetskaya, N.F.3    Shabarova, Z.A.4
  • 47
    • 0033027040 scopus 로고    scopus 로고
    • Potential inhibitors of HIV integrase
    • Mathe C, Nair V. Potential inhibitors of HIV integrase. Nucleosides & Nucleotides 1999; 18: 681-682.
    • (1999) Nucleosides & Nucleotides , vol.18 , pp. 681-682
    • Mathe, C.1    Nair, V.2
  • 50
    • 0344720683 scopus 로고
    • A peptide inhibitor of HIV-1 integrase from a combinatorial library
    • Abstracts of the NIH Conference on Retroviral Integrase, Bethesda MD. January 19-20
    • Puras Lutze RA, Eppens NA, Weber P, Houghten RA, Plasterk RHA. A peptide inhibitor of HIV-1 integrase from a combinatorial library. Abstracts of the NIH Conference on Retroviral Integrase, Bethesda MD. 1995; January 19-20.
    • (1995)
    • Puras Lutze, R.A.1    Eppens, N.A.2    Weber, P.3    Houghten, R.A.4    Plasterk, R.H.A.5
  • 51
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000; 287: 646-650.
    • (2000) Science , vol.287 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3    Wolfe, A.4    Stillmock, K.5    Grobler, J.A.6
  • 52
    • 0034727864 scopus 로고    scopus 로고
    • 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells
    • Wai JS, Egbertson MS, Payne LS, Fisher TE, Embrey MW, Tran LO, et al. 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells. J Med Chem 2000; 43: 4923-4926.
    • (2000) J. Med. Chem. , vol.43 , pp. 4923-4926
    • Wai, J.S.1    Egbertson, M.S.2    Payne, L.S.3    Fisher, T.E.4    Embrey, M.W.5    Tran, L.O.6
  • 53
    • 0028070994 scopus 로고
    • Inhibition of HIV integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds
    • Fesen M, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW. Inhibition of HIV integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 1994; 48: 595-608.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 595-608
    • Fesen, M.1    Pommier, Y.2    Leteurtre, F.3    Hiroguchi, S.4    Yung, J.5    Kohn, K.W.6
  • 55
    • 0036231063 scopus 로고    scopus 로고
    • Trends in the design of nucleoside analogues as anti-HIV drugs
    • el Kouni MH. Trends in the design of nucleoside analogues as anti-HIV drugs. Curr Pharm Design 2002; 8(8): 581-93.
    • (2002) Curr. Pharm. Design , vol.8 , Issue.8 , pp. 581-593
    • el Kouni, M.H.1
  • 56
    • 0036223198 scopus 로고    scopus 로고
    • Peptide and non-peptide HIV fusion inhibitors
    • Jiang S, Zhao Q, Debnath AK. Peptide and non-peptide HIV fusion inhibitors. Curr Pharm Design 2002; 8(8): 563-80.
    • (2002) Curr. Pharm. Design , vol.8 , Issue.8 , pp. 563-580
    • Jiang, S.1    Zhao, Q.2    Debnath, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.