MEK inhibits secretin release and pancreatic secretion: Roles of secretin-releasing peptide and somatostatin

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 280, Issue 5 43-5, 2001, Pages

  Li, James P ^a   Lee, Kae Yol ^a   Chang, Ta Min ^a   Chey, William Y ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Rochester Institute for Digestive Diseases and Sciences   (United States)

Author keywords

Anti somatostatin serum; Bicarbonate secretion; Fluid; Naloxone; Rats

Indexed keywords

METENKEPHALIN; NALOXONE; RELEASING FACTOR; SECRETIN; SOMATOSTATIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; NONHUMAN; PANCREAS; PANCREAS SECRETION; PRIORITY JOURNAL; RAT; SERUM;

EID: 0035026797     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.280.5.g890     Document Type: Article

References (33)

1. Accili EA, Dhatt N, and Buchan AM. Neural somatostatin, vasoactive intestinal polypeptide and substance P in canine and human jejunum. Neurosci Lett 185: 37-40, 1995.
2. Accili EA, McIntosh CH, and Buchan AM. The release of somatostatin-14 from human submucosal ganglia in tissue culture. Can J Physiol Pharmacol 71: 619-624, 1993.
3. Chang T-M and Chey WY. Radioimmunoassay of secretin: a critical review. Dig Dis Sci 25: 529-552, 1980.
4. Chey WY, Coy DH, Konturek SJ, Schally AV, and Tasler J. Enkephalin inhibits the release and action of secretin on pancreatic secretion in the dog. J Physiol (Lond) 298: 429-436, 1980.
5. Dooley CP, Sead MC, and Valenzuela JE. Studies on the role of opioids in control of human pancreatic secretion. Dig Dis Sci 33: 598-604, 1988.
6. Eklund S, Sjoqvist A, Fahrenkrug J, Jodal M, and Lundgren O. Somatostatin and methionine-enkephalin inhibit cholera toxin-induced jejunal net fluid secretion and release of vasoactive intestinal polypeptide in the cat in vivo. Acta Physiol Scand 133: 551-557, 1988.
7. Ferri GL, Botti P, Biliotti G, Rebecchi L, Bloom SR, Tonelli L, Labo G, and Polak JM. VIP-, substance P- and met-enkephalin-immunoreactive innervation of the human gastroduodenal mucosa and Brunner's glands. Gut 25: 948-952 1984.
8. Gullo L, Priori P, Baldoni F, and Mattioli G. Stimulation of exocrine pancreatic secretion by met-enkephalin. Gut 27: 1479-1483, 1986.
9. Hens J, Schrodl F, Brehmer A, Adriaensen D, Neuhuber W, Scheuermann DW, Schemann M, and Timmermans JP. Mucosal projections of enteric neurons in the porcine small intestine. J Comp Neurol 421: 429-436, 2000.
10. Hermansen K. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology 113: 1149-1154, 1983.
11. Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, and Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258: 577-579, 1975.
12. Konturek SJ, Kwieciew N, Dobranska M, Gawranek J, Olesky J, and Coy DH. Effect of enkephalin and naloxone on vagal and hormonal stimulation of pancreatic secretion in man. Scand J Gastroenterol 18: 679-684, 1983.
13. Konturek SJ, Tasler J, Cieszkowki W, Jaworek J, Coy DH, and Schally AV. Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology 74: 851-855, 1978.
14. Larsson L. Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/CCK immunoreactive nerves. J Histochem Cytochem 27: 1283-1284, 1979.
15. Lee KY, Krusch D, Zhou L, Song Y, Chang T-M, and Chey WY. Effect of endogenous insulin on pancreatic exocrine secretion in perfused dog pancreas. Pancreas 11: 190-195, 1995.
16. Lee KY, Lee YL, Kim CD, Chang T-M, and Chey WY. Mechanism of action of insulin on pancreatic exocrine secretion in perfused rat pancreas. Am J Physiol Gastrointest Liver Physiol 267: G207-G212, 1994.
17. Li P, Chang T-M, and Chey WY. Neuronal regulation of the release and action of secretin-releasing peptide and secretin. Am J Physiol Gastrointest Liver Physiol 269: G305-G312, 1995.
18. Li P, Lee KY, Chang T-M, and Chey WY. Mechanism of acid-induced release of secretin in rats: presence of a secretin releasing peptide. J Clin Invest 86: 1474-1479, 1990.
19. Li ZS and Furness JB. Immunohistochemical localization of cholinergic markers in putative intrinsic primary afferent neurons of the guinea-pig small intestine. Cell Tissue Res 294: 35-43, 1998.
20. Lucey MR, Mass JAH, Fairclough PD, O'Hare M, Kwasowski P, Penman E, Wegg J, and Rees LH. Does gastric acid release plasma somatostatin in man? Gut 25: 1217-1220, 1984.
21. Mate L and Greeley GH Jr. Opioid peptide (endorphins and enkephalins). In: Gastrointestinal Endocrinology, edited by Thompson JC. New York: McGraw-Hill, 1987, p.346-354.
22. Matsumura M, Fukuda N, Saito S, and Mori H. Effect of a test meal, duodenal acidification, and tetragastrin on the plasma concentration of β-endorphin-like immunoreactivity in man. Regul Pept 4: 173-181, 1982.
23. McIntosh C, Arnold R, and Rothe E. Gastrointestinal somatostatin: extraction and radioimmunoassay in different species. Gut 19: 655-663, 1978.
24. Murthy SN, Lavy A, Morgantini DS, and Chey WY. Neurohormonal regulation of secretin secretion in canine duodenal mucosa in vitro. Peptides 1, Suppl: 229-236, 1986.
25. Polak JM, Pearse AGE, Gremelius L, Bloom SR, and Arimura A. Growth-hormone releasing-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet 1: 1220-1222, 1975.
26. Polak JM, Bloom SR, Sullivan SN, Facer P, and Pearse AGE. Enkephalin-like immunoreactivity in the human gastrointestinal tract. Lancet 1: 972-974, 1977.
27. Rhee JC, Chang T-M, Lee KY, Jo H, and Chey WY. Mechanism of oleic acid-induced inhibition on gastric acid secretion in rats. Am J Physiol Gastrointest Liver Physiol 260: G564-G570, 1991.
28. Di Scala-Guenot D and McIntosh CH. The effect of metenkephalin and naloxone on somatostatin and insulin secretion from the isolated, perfused rat pancreas. Diabetes 34: 1283-1287, 1985.
29. Schafer J and Meyerhof W. sst1 mRNA is the prominent somatostatin receptor mRNA in the rat gastrointestinal tract: reverse transcription polymerase chain reaction and in situ-hybridization study. Neuropeptides 33: 457-463, 1999.
30. Stern AS, Wurzburger RJ, Barkey R, and Spector S. Opioid polypeptides in guinea pig pancreas. Proc Natl Acad Sci USA 79: 6703-6706, 1982.
31. Surprenant A, Shen KZ, North RA, and Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea pig submucosal neurons. J Physiol (Lond) 431: 585-608, 1990.
32. Varga G, Kisfalvi I Jr, Kordas K, Wong H, Walsh JH, and Solomon TE. Effect of somatostatin immunoneutralization on gastric acid and pancreatic enzyme secretion in anesthetized rats. J Physiol (Paris) 91: 223-227, 1997.
33. Yang H, Wong H, Wu V, Walsh JH, and Tache Y. Somatostatin monoclonal antibody immunoneutralization increases gastrin and gastric acid secretion in urethane-anesthetized rats. Gastroenterology 99: 659-665, 1990.