Effect of in vitro ischemic or hypoxic treatment on mitochondrial electron transfer activity in rat brain slices assessed by gas-tissue autoradiography using [15O] molecular oxygen

Brain Research

Volumn 890, Issue 1, 2001, Pages 100-109

  Sasaki, Tom ^a   Senda, Michio ^a   Ohno, Tomohisa ^a,b   Kojima, Shuji ^b   Kubodera, Akiko ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

15O Oxygen; Brain slice; Hypoxia; Ischemia; Mitochondria; Visualization

Indexed keywords

OXYGEN 15;

AGED; AGING; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN SLICE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ELECTRON TRANSPORT; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SENESCENCE;

AGE FACTORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ASPIRIN; AUTORADIOGRAPHY; CEREBRAL CORTEX; CORPUS STRIATUM; ELECTRON TRANSPORT; GLUTATHIONE; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; MALE; MITOCHONDRIA; ORGAN CULTURE TECHNIQUES; OXYGEN RADIOISOTOPES; RATS; RATS, WISTAR; TISSUE FIXATION;

EID: 0035951648     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03143-7     Document Type: Article

References (45)

1. Effect of alpha-tocopherol and free radicals on anoxic damage in the rat hippocampal slice
2. Dietary carcinogens and anticarcinogens
3. Mitochondrial aging: Open questions
4. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system
5. Role of oxidants in ischemic brain damage
6. Mitochondria in neurodegeneration: Acute ischemia and chronic neurogenerative diseases
7. Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: Involvement of NMDA-receptors
8. Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury
9. Mitochondrial decay in aging reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-α-phenyl-nitrone
10. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
11. Anti-inflammatory drugs: Protection of a bacterial virus as an in vitro biological measure of free radical activity
12. Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid
13. Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging
14. Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2′-deoxyguanosine in organs of Fischer 344 rats during aging
15. Ischemic cell death in brain neurons
16. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs
17. The calculation of the cytoplasmic free [NADP+]/[NADPH] ratio in brain: Effect of electroconvulsive seizure
18. Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices
19. Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia- and acidosis-induced damage in hippocampal slices
20. The protective effect of hypothermia on reversibility in the neuronal function of the hippocampal slice during long lasting anoxia
21. Effects of accumulation of phosphocreatine on the survival time of thin hippocampal slices from the guinea pig during deprivation of both oxygen and glucose
22. Calcium influx from the extracellular space promotes NADH hyperoxidation and electrical dysfunction after anoxia in hippocampal slices
23. Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices
24. Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemia
25. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
26. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat
27. Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia
28. Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells
29. Determination of acetylsalicylic acid and metabolites in biological fluids by high-performance liquid chromatography
30. Acetylsalicylic acid increases tolerance against hypoxic and chemical hypoxia
31. Determination of Aspirin and its major metabolites in plasma by high-performance liquid chromatography without solvent extraction
32. Free radical-induced elevation of ornithine decarboxylase activity in developing rat brain slices
33. 15O] molecular oxygen for visualization of mitochondrial oxygen fixation in brain slices
34. Technetium-99m meso-hexamethyl propyleneamine oxime as a potential agent for imaging cerebral glutathione content
35. Visualization of mitochondrial oxygen fixation in brain slices by gas-tissue autoradiography
36. Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: Online measurement using enhanced chemiluminescence
37. Glutathione protects against hypoxic/hypoglycemic decreases in 2-deoxyglucose uptake and presynaptic spikes in hippocampal slices
38. Oxidative damage and mitochondrial decay in aging
39. Is the cell death pathway triggered by the mitochondrion or endoplasmic reticulum?
40. Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice
41. The protective effect of hypothermia on hippocampal slices from guinea pig during deprivation of oxygen and glucose
42. Pharmacological protection of reoxygenation damage to in vitro brain slice tissue
43. Effect of stobadine, U-74389G, trolox and melatonin on resistance of rat hippocampal slices to oxidative stress
44. Assessment of long-term effects of transient anoxia on metabolic activity of rat hippocampal slices using triphenyltetrazolium chloride
45. Immunocytochemical and in situ hybridization approaches to the optimization of brain slice preparations