Mutations in the Effector Binding Loops in the C2A and C2B Domains of Synaptotagmin I Disrupt Exocytosis in a Nonadditive Manner

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 47030-47037

  Wang, Ping ^b   Wang, Chih Tien ^a   Bai, Jihong ^b   Jackson, Meyer B ^a   Chapman, Edwin R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b SMI 129 ^*

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELL MEMBRANES; ELECTROSTATICS; LIPIDS; MUTAGENESIS;

EXOCYTOSIS; MEMBRANE FUSION; MUTATIONS;

PROTEINS;

ARGININE; CALCIUM; GLUTAMINE; LIPOSOME; LYSINE; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CHEMOSENSITIVITY; CONTROLLED STUDY; ELECTRICITY; EXOCYTOSIS; MEMBRANE BINDING; MOLECULE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT;

ANIMALS; BINDING SITES; CALCIUM; CALCIUM-BINDING PROTEINS; ELECTROSTATICS; EXOCYTOSIS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

ANIMALIA;

EID: 0344012489     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306728200     Document Type: Article

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